Involvement of hepatocyte growth factor/scatter factor and Met receptor signaling in hair follicle morphogenesis and cycling

2000 ◽  
Vol 14 (2) ◽  
pp. 319-332 ◽  
Author(s):  
Gerd Lindner ◽  
Andreas Menrad ◽  
Ermanno Gherardi ◽  
Glenn Merlino ◽  
Pia Welker ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hair Follicle ◽  
Receptor Signaling ◽  
Met Receptor ◽  
Scatter Factor ◽  
Hepatocyte Growth

scholarly journals Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 ◽  
Vol 10 (10) ◽  
pp. 2867-2878 ◽  
Author(s):  
L. Naldini ◽  
K.M. Weidner ◽  
E. Vigna ◽  
G. Gaudino ◽  
A. Bardelli ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Met Receptor ◽  
Scatter Factor ◽  
Hepatocyte Growth

scholarly journals The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 ◽  
Vol 121 (1) ◽  
pp. 145-154 ◽  
Author(s):  
K M Weidner ◽  
M Sachs ◽  
W Birchmeier
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Hepatocyte Growth Factor ◽  
Tyrosine Kinase ◽  
Cell Motility ◽  
Receptor Tyrosine Kinase ◽  
Met Receptor ◽  
Scatter Factor ◽  
Met Receptor Tyrosine Kinase ◽  
Hepatocyte Growth

Depending on the target cells and culture conditions, scatter factor/hepatocyte growth factor (SF/HGF) mediates several distinct activities, i.e., cell motility, proliferation, invasiveness, tubular morphogenesis, angiogenesis, or cytotoxicity. A small isoform of SF/HGF encoded by a natural splice variant, which consists of the NH2-terminal hairpin structure and the first two kringle domains but not the protease homology region, induces cell motility but not mitogenesis. Two types of SF/HGF receptors have recently been discovered in epithelial cells, the high affinity c-Met receptor tyrosine kinase, and low affinity/high capacity binding sites, which are probably located on heparan sulfate proteoglycans. In the present study, we have addressed the question whether the various biological activities of SF/HGF are transduced into cells by a single type of receptor. We have here examined MDCK epithelial cells transfected with a hybrid cDNA encoding the ligand binding domain of the nerve growth factor (NGF) receptor and the membrane-spanning and tyrosine kinase domains of the Met receptor. We demonstrate that all biological effects of SF/HGF upon epithelial cells such as the induction of cell motility, proliferation, invasiveness, and tubular morphogenesis can now be triggered by the addition of NGF. Thus, it is likely that all known biological signals of SF/HGF are transduced through the receptor tyrosine kinase encoded by the c-Met protooncogene.

Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma

1998 ◽  
Vol 432 (4) ◽  
pp. 337-342 ◽  
Author(s):  
C. Kuhnen ◽  
Edina Tolnay ◽  
Hans Ulrich Steinau ◽  
Bruno Voss ◽  
Klaus-Michael Müller
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Synovial Sarcoma ◽  
Epithelioid Sarcoma ◽  
Met Receptor ◽  
Scatter Factor ◽  
Hepatocyte Growth

Hepatocyte growth factor / scatter factor and m-MET receptor expression during murine anagen development

1998 ◽  
Vol 16 ◽  
pp. S151
Author(s):  
Gerd Lindner ◽  
Andreas Menrad ◽  
Pia Welker ◽  
Sven Mueller-Roever ◽  
Ralf Paus
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Receptor Expression ◽  
Met Receptor ◽  
Scatter Factor ◽  
Hepatocyte Growth
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