scholarly journals Adrenergic Receptor Characterization of Rat Hippocampal CA3 Pyramidal Neurons Using Real Time Single Cell RT‐PCR

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Hana Hammad ◽  
Kristin Hillman ◽  
James Porter ◽  
Van Doze
Keyword(s):  
Single Cell ◽  
Real Time ◽  
Adrenergic Receptor ◽  
Pyramidal Neurons ◽  
Rt Pcr ◽  
Hippocampal Ca3 ◽  
Ca3 Pyramidal Neurons

scholarly journals Adrenergic receptor characterization of rat hippocampal neurons using real time single cell RT‐PCR

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Ke Xu ◽  
Kristin Hillman ◽  
Hana Hammad ◽  
Chris Jurgens ◽  
Brianna Goldenstein ◽  
...  
Keyword(s):  
Single Cell ◽  
Real Time ◽  
Adrenergic Receptor ◽  
Hippocampal Neurons ◽  
Rt Pcr

Adrenergic receptor characterization of CA1 hippocampal neurons using real time single cell RT-PCR

2005 ◽  
Vol 139 (2) ◽  
pp. 267-276 ◽  
Author(s):  
Kristin L. Hillman ◽  
Chris A. Knudson ◽  
Patrick A. Carr ◽  
Van A. Doze ◽  
James E. Porter
Keyword(s):  
Single Cell ◽  
Real Time ◽  
Adrenergic Receptor ◽  
Hippocampal Neurons ◽  
Rt Pcr

P.1.g.089 Ethanol modulates in a biphasic manner hyperpolarisation-activated currents (Ih) in rat hippocampal CA3 pyramidal neurons

2014 ◽  
Vol 24 ◽  
pp. S255-S256
Author(s):  
V. Licheri ◽  
G. Talani ◽  
J. Di Lucente ◽  
G. Biggio ◽  
E. Sanna
Keyword(s):  
Pyramidal Neurons ◽  
Hippocampal Ca3 ◽  
Ca3 Pyramidal Neurons

scholarly journals Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Omar Babateen ◽  
Sergiy V. Korol ◽  
Zhe Jin ◽  
Amol K. Bhandage ◽  
Aikeremu Ahemaiti ◽  
...  
Keyword(s):  
Pyramidal Neurons ◽  
Hippocampal Ca3 ◽  
Ca3 Pyramidal Neurons

scholarly journals Computational Analysis of the Impact of Chronic Stress on Intrinsic and Synaptic Excitability in the Hippocampus

2010 ◽  
Vol 103 (6) ◽  
pp. 3070-3083 ◽  
Author(s):  
Rishikesh Narayanan ◽  
Sumantra Chattarji
Keyword(s):  
Chronic Stress ◽  
Pyramidal Neurons ◽  
Three Dimensional ◽  
Input Resistance ◽  
Synaptic Potentiation ◽  
Synaptic Inputs ◽  
Hippocampal Ca3 ◽  
Ca3 Pyramidal Neurons ◽  
Dendritic Atrophy ◽  
The Impact

Dendritic atrophy and impaired long-term synaptic potentiation (LTP) are hallmarks of chronic stress-induced plasticity in the hippocampus. It has been hypothesized that these disparate structural and physiological correlates of stress lead to hippocampal dysfunction by reducing postsynaptic dendritic surface, thereby adversely affecting the availability of synaptic inputs and suppressing LTP. Here we examine the validity of this framework using biophysical models of hippocampal CA3 pyramidal neurons. To statistically match with the experimentally observed region specificity of stress-induced atrophy, we use an algorithm to systematically prune three-dimensional reconstructions of CA3 pyramidal neurons. Using this algorithm, we build a biophysically realistic computational model to analyze the effects of stress on intrinsic and synaptic excitability. We find that stress-induced atrophy of CA3 dendrites leads to an increase in input resistance, which depends exponentially on the percentage of neuronal atrophy. This increase translates directly into higher spiking frequencies in response to both somatic current injections and synaptic inputs at various locations along the dendritic arbor. Remarkably, we also find that the dendritic regions that manifest atrophy-induced synaptic hyperexcitability are governed by the region specificity of the underlying dendritic atrophy. Coupled with experimentally observed modulation of N-methyl-d-aspartate receptor currents, such hyperexcitability could tilt the balance of plasticity mechanisms in favor of synaptic potentiation over depression. Thus paradoxically, our results suggest that stress may impair hippocampal learning and memory, not by directly inhibiting LTP, but because of stress-induced facilitation of intrinsic and synaptic excitability and the consequent imbalance in bidirectional synaptic plasticity.

scholarly journals Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

2019 ◽  
Author(s):  
Nuno Apóstolo ◽  
Samuel N. Smukowski ◽  
Jeroen Vanderlinden ◽  
Giuseppe Condomitti ◽  
Vasily Rybakin ◽  
...  
Keyword(s):  
Cell Surface ◽  
Pyramidal Neurons ◽  
Mossy Fiber ◽  
Surface Protein ◽  
Guidance Cue ◽  
Hippocampal Ca3 ◽  
Cell Surface Interactions ◽  
Ca3 Pyramidal Neurons ◽  
Ca3 Neurons ◽  
Multiple Ligand

SummarySynaptic diversity is a key feature of neural circuits. The structural and functional diversity of closely spaced inputs converging on the same neuron suggests that cell-surface interactions are essential in organizing input properties. Here, we analyzed the cell-surface protein (CSP) composition of hippocampal mossy fiber (MF) inputs on CA3 pyramidal neurons to identify regulators of MF-CA3 synapse properties. We uncover a rich cell-surface repertoire that includes adhesion proteins, guidance cue receptors, extracellular matrix (ECM) proteins, and uncharacterized CSPs. Interactome screening reveals multiple ligand-receptor modules and identifies ECM protein Tenascin-R (TenR) as a ligand of the uncharacterized neuronal receptor IgSF8. Presynaptic Igsf8 deletion impairs MF-CA3 synaptic architecture and robustly decreases the density of bouton filopodia that provide feedforward inhibition of CA3 neurons. Consequently, loss of IgSF8 increases CA3 neuron excitability. Our findings identify IgSF8 as a regulator of CA3 microcircuit development and suggest that combinations of CSP modules define input identity.

scholarly journals GLP-1 and Exendin-4 Transiently Enhance GABAAReceptor–Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Diabetes ◽  
2014 ◽  
Vol 64 (1) ◽  
pp. 79-89 ◽  
Author(s):  
Sergiy V. Korol ◽  
Zhe Jin ◽  
Omar Babateen ◽  
Bryndis Birnir
Keyword(s):  
Pyramidal Neurons ◽  
Hippocampal Ca3 ◽  
Ca3 Pyramidal Neurons
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