scholarly journals Statins attenuate thrombin‐stimulated tissue factor expression on human endothelial cells through regulation of cJun

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Marilyn J. Woolkalis ◽  
Colleen M. Fitzpatrick
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Tissue Factor Expression ◽  
Human Endothelial Cells ◽  
Factor Expression

scholarly journals Statin Prevents Tissue Factor Expression in Human Endothelial Cells

Circulation ◽  
2002 ◽  
Vol 105 (15) ◽  
pp. 1756-1759 ◽  
Author(s):  
Masato Eto ◽  
Toshiyuki Kozai ◽  
Francesco Cosentino ◽  
Hana Joch ◽  
Thomas F. Lüscher
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Tissue Factor Expression ◽  
Human Endothelial Cells ◽  
Factor Expression

scholarly journals Induction of tissue factor activity in endothelial cells and monocytes by a modified form of albumin present in normal human plasma

Blood ◽  
1992 ◽  
Vol 79 (11) ◽  
pp. 2888-2895
Author(s):  
KJ Faucette ◽  
CJ Parker ◽  
T McCluskey ◽  
NJ Bernshaw ◽  
GM Rodgers
Keyword(s):  
Endothelial Cells ◽  
Human Plasma ◽  
Tissue Factor ◽  
Tissue Factor Expression ◽  
Factor Activity ◽  
Normal Human Plasma ◽  
Human Endothelial Cells ◽  
Tissue Factor Activity ◽  
Factor Expression ◽  
Normal Human

Molecules that induce tissue factor expression by responsive cells such as endothelial cells and monocytes may be important in the regulation of hemostasis and, perhaps, in mediating certain hemostatic disorders. A constituent of normal human plasma capable of inducing tissue factor activity in human endothelial cells and monocytes has been isolated and identified as a derivative of, or modification associated with albumin. Procoagulant albumin caused a concentration-dependent induction of tissue factor expression by human endothelial cells, but bovine endothelial cells were unresponsive. The dose-response curve developed a plateau phase, indicating that the capacity of endothelial cells to respond to the stimulus was finite. The maximum response induced by the procoagulant albumin was similar to that observed for maximally effective concentrations of endotoxin, interleukin-1, and tumor necrosis factor. Time-course studies showed that procoagulant albumin produced peak activity in 4 to 6 hours. Identification of a procoagulant form of albumin in normal human plasma suggests a potential role for this constituent in regulation of hemostasis.

scholarly journals Induction of tissue factor activity in endothelial cells and monocytes by a modified form of albumin present in normal human plasma

Blood ◽  
1992 ◽  
Vol 79 (11) ◽  
pp. 2888-2895 ◽  
Author(s):  
KJ Faucette ◽  
CJ Parker ◽  
T McCluskey ◽  
NJ Bernshaw ◽  
GM Rodgers
Keyword(s):  
Endothelial Cells ◽  
Human Plasma ◽  
Tissue Factor ◽  
Tissue Factor Expression ◽  
Factor Activity ◽  
Normal Human Plasma ◽  
Human Endothelial Cells ◽  
Tissue Factor Activity ◽  
Factor Expression ◽  
Normal Human

Abstract Molecules that induce tissue factor expression by responsive cells such as endothelial cells and monocytes may be important in the regulation of hemostasis and, perhaps, in mediating certain hemostatic disorders. A constituent of normal human plasma capable of inducing tissue factor activity in human endothelial cells and monocytes has been isolated and identified as a derivative of, or modification associated with albumin. Procoagulant albumin caused a concentration-dependent induction of tissue factor expression by human endothelial cells, but bovine endothelial cells were unresponsive. The dose-response curve developed a plateau phase, indicating that the capacity of endothelial cells to respond to the stimulus was finite. The maximum response induced by the procoagulant albumin was similar to that observed for maximally effective concentrations of endotoxin, interleukin-1, and tumor necrosis factor. Time-course studies showed that procoagulant albumin produced peak activity in 4 to 6 hours. Identification of a procoagulant form of albumin in normal human plasma suggests a potential role for this constituent in regulation of hemostasis.

scholarly journals Long Pentraxin PTX3 Upregulates Tissue Factor Expression in Human Endothelial Cells

2002 ◽  
Vol 22 (5) ◽  
pp. 782-787 ◽  
Author(s):  
Emanuela Napoleone ◽  
Angelomaria Di Santo ◽  
Antonio Bastone ◽  
Giuseppe Peri ◽  
Alberto Mantovani ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tissue Factor ◽  
Tissue Factor Expression ◽  
Human Endothelial Cells ◽  
Factor Expression
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