Contrasting Reflex Neural Modulation of Muscle Sympathetic Nerve Activity at Rest and During One‐leg Dynamic Exercise in Subjects with and without Heart Failure

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Catherine F. Notarius ◽  
Daniel A. Keir ◽  
Mark B. Badrov ◽  
Philip J. Millar ◽  
Paul Oh ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Dynamic Exercise ◽  
Nerve Activity ◽  
Neural Modulation

Carotid baroreflex regulation of sympathetic nerve activity during dynamic exercise in humans

2001 ◽  
Vol 280 (3) ◽  
pp. H1383-H1390 ◽  
Author(s):  
P. J. Fadel ◽  
S. Ogoh ◽  
D. E. Watenpaugh ◽  
W. Wasmund ◽  
A. Olivencia-Yurvati ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Dynamic Exercise ◽  
Moderate Intensity ◽  
Burst Frequency ◽  
Nerve Activity ◽  
Arm Cycling ◽  
Carotid Baroreflex ◽  
Neck Pressure

We sought to determine whether carotid baroreflex (CBR) control of muscle sympathetic nerve activity (MSNA) was altered during dynamic exercise. In five men and three women, 23.8 ± 0.7 (SE) yr of age, CBR function was evaluated at rest and during 20 min of arm cycling at 50% peak O2uptake using 5-s periods of neck pressure and neck suction. From rest to steady-state arm cycling, mean arterial pressure (MAP) was significantly increased from 90.0 ± 2.7 to 118.7 ± 3.6 mmHg and MSNA burst frequency (microneurography at the peroneal nerve) was elevated by 51 ± 14% ( P < 0.01). However, despite the marked increases in MAP and MSNA during exercise, CBR-Δ%MSNA responses elicited by the application of various levels of neck pressure and neck suction ranging from +45 to −80 Torr were not significantly different from those at rest. Furthermore, estimated baroreflex sensitivity for the control of MSNA at rest was the same as during exercise ( P = 0.74) across the range of neck chamber pressures. Thus CBR control of sympathetic nerve activity appears to be preserved during moderate-intensity dynamic exercise.

Tonic Chemoreflex Activation Does Not Contribute to Elevated Muscle Sympathetic Nerve Activity in Heart Failure

Circulation ◽  
1996 ◽  
Vol 94 (6) ◽  
pp. 1325-1328 ◽  
Author(s):  
Philippe van de Borne ◽  
Ron Oren ◽  
Erling A. Anderson ◽  
Allyn L. Mark ◽  
Virend K. Somers
Keyword(s):  
Heart Failure ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Nerve Activity
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