scholarly journals Selective Afferent Denervation in Epididymal White Adipose Tissue Reduces Blood Pressure in Obese Male Mice Exposed to Early Life Stress

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Carolina Dalmasso ◽  
Jacqueline Leachman ◽  
Nermin Ahmed ◽  
Sundus Ghuneim ◽  
Analia Loria
Keyword(s):  
Blood Pressure ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice ◽  
Epididymal White Adipose Tissue ◽  
Obese Male

scholarly journals Epididymal Fat-Derived Sympathoexcitatory Signals Exacerbate Neurogenic Hypertension in Obese Male Mice Exposed to Early Life Stress

Hypertension ◽  
2021 ◽  
Author(s):  
Carolina Dalmasso ◽  
Jacqueline R. Leachman ◽  
Sundus Ghuneim ◽  
Nermin Ahmed ◽  
Eve R. Schneider ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
White Adipose Tissue ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice ◽  
Epididymal White Adipose Tissue ◽  
Obese Male

Previously, we have shown that male mice exposed to maternal separation and early weaning (MSEW)—a mouse model of early life stress—display increased mean arterial pressure compared with controls when fed a high-fat diet. As the stimulation of sensory nerves from fat has been shown to trigger the adipose afferent reflex, we tested whether MSEW male mice show obesity-associated hypertension via the hyperactivation of this sympathoexcitatory mechanism. After 16 weeks on high-fat diet, MSEW mice displayed increased blood pressure, sympathetic activation, and greater depressor response to an α-adrenergic blocker when compared with controls ( P <0.05; n=8), despite no differences in adiposity and plasma leptin. The acute infusion of capsaicin in epididymal white adipose tissue (1.5 pmol/μL of capsaicin, 8 μL/per site, 4 sites, bilaterally) increased the total pressor response in MSEW mice compared with controls (110±19 versus 284±33 mm Hg×30 minutes; P <0.05; n=8). This response was associated with neuronal activation in OVLT, posterior paraventricular nucleus of the hypothalamus, and RVLM ( P <0.05 versus control; n=6–7). Renal denervation abolished both the acute and chronic elevated mean arterial pressure in obese MSEW mice. Moreover, selective sensory denervation of epididymal white adipose tissue using resiniferatoxin (10 pmol/µL solution; n=6) decreased mean arterial pressure in obese MSEW mice only ( P <0.05 versus control). Obese MSEW mice displayed increased epididymal white adipose tissue levels of both tryptophan hydroxylase (Tph1) mRNA expression and its synthesis product serotonin (8.3±1.9 versus 16.6±1.7 ug/mg tissue; P <0.05 versus control). Thus, afferent sensory signals from epididymal white adipose tissue may contribute to the exacerbated fat–brain–blood pressure axis displayed by obese male mice exposed to early life stress.

scholarly journals Capsaicin‐Induced Stimulation of Sensory Neurons in Adipose Tissue Promotes Increases in Blood Pressure in Mice Exposed to Early Life Stress

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Carolina Dalmasso ◽  
Jacqueline R. Leachman ◽  
Sophia Mounce ◽  
Xiu Xu ◽  
Analia S. Loria
Keyword(s):  
Blood Pressure ◽  
Adipose Tissue ◽  
Sensory Neurons ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Stimulation Of

Abstract 138: Acute Stimulation of Neuro-Adipose Connections Increase Blood Pressure Responses in Male Mice Exposed to Early Life Stress

Hypertension ◽  
2019 ◽  
Vol 74 (Suppl_1) ◽  
Author(s):  
Carolina Dalmasso ◽  
Sophia Mounce ◽  
Jacqueline Leachman ◽  
Xiu Xu ◽  
Analia Loria
Keyword(s):  
Blood Pressure ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Increase Blood Pressure ◽  
Male Mice ◽  
Blood Pressure Responses ◽  
Stimulation Of

scholarly journals Effects of early-life stress on peripheral and central mitochondria in male mice across ages

2021 ◽  
pp. 105346
Author(s):  
S.R. Ruigrok ◽  
K. Yim ◽  
T.L. Emmerzaal ◽  
B. Geenen ◽  
N. Stöberl ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice

scholarly journals Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice

2017 ◽  
Vol 77 ◽  
pp. 186-195 ◽  
Author(s):  
K.Y. Yam ◽  
E.F.G. Naninck ◽  
M.R. Abbink ◽  
S.E. la Fleur ◽  
L. Schipper ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Leptin System

scholarly journals Early life stress impairs contextual threat expression in female, but not male, mice.

2018 ◽  
Vol 132 (4) ◽  
pp. 247-257 ◽  
Author(s):  
Gabriela Manzano-Nieves ◽  
Mizan Gaillard ◽  
Meghan Gallo ◽  
Kevin G. Bath
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Mice

scholarly journals Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice

Pain ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Isabella M. Fuentes ◽  
Brittni M. Jones ◽  
Aaron D. Brake ◽  
Angela N. Pierce ◽  
Olivia C. Eller ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Chronic Pelvic Pain ◽  
Wheel Running ◽  
Chronic Pelvic Pain Syndrome ◽  
Early Life Stress ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Male Mice ◽  
Voluntary Wheel
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