Fatty acid beta oxidation is the source of malonyl‐CoA for fatty acid chain elongation in rat heart

Janos Kerner; Paul Minkler; Maria Stoll; Charles Hoppel

doi:10.1096/fasebj.23.1_supplement.793.6

Fatty acid beta oxidation is the source of malonyl‐CoA for fatty acid chain elongation in rat heart

The FASEB Journal ◽

10.1096/fasebj.23.1_supplement.793.6 ◽

2009 ◽

Vol 23 (S1) ◽

Author(s):

Janos Kerner ◽

Paul Minkler ◽

Maria Stoll ◽

Charles Hoppel

Keyword(s):

Fatty Acid ◽

Rat Heart ◽

Chain Elongation ◽

Beta Oxidation ◽

Fatty Acid Chain ◽

Malonyl Coa ◽

Fatty Acid Beta Oxidation

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Fatty acid chain elongation in palmitate‐perfused working rat heart: mitochondrial acetyl‐CoA is the source of two‐carbon units for chain elongation (758.2)

The FASEB Journal ◽

10.1096/fasebj.28.1_supplement.758.2 ◽

2014 ◽

Vol 28 (S1) ◽

Author(s):

Janos Kerner ◽

Paul Minkler ◽

Edward Lesnefsky ◽

Charles Hoppel

Keyword(s):

Fatty Acid ◽

Rat Heart ◽

Chain Elongation ◽

Acetyl Coa ◽

Fatty Acid Chain ◽

Working Rat Heart

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Fatty Acid Chain Elongation in Palmitate-perfused Working Rat Heart

Journal of Biological Chemistry ◽

10.1074/jbc.m113.524314 ◽

2014 ◽

Vol 289 (14) ◽

pp. 10223-10234 ◽

Cited By ~ 17

Author(s):

Janos Kerner ◽

Paul E. Minkler ◽

Edward J. Lesnefsky ◽

Charles L. Hoppel

Keyword(s):

Fatty Acid ◽

Rat Heart ◽

Chain Elongation ◽

Fatty Acid Chain ◽

Working Rat Heart

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Is there a single malonyl‐CoA pool in the heart for regulation of carnitine palmitoyltransferase‐I and fatty acid chain elongation

The FASEB Journal ◽

10.1096/fasebj.20.4.a139-a ◽

2006 ◽

Vol 20 (4) ◽

Author(s):

Janos Kerner ◽

Paul Minkler ◽

Charles Hoppel

Keyword(s):

Fatty Acid ◽

Carnitine Palmitoyltransferase ◽

Chain Elongation ◽

Fatty Acid Chain ◽

Malonyl Coa ◽

Carnitine Palmitoyltransferase I

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Fatty acid chain-elongation in perfused rat heart: Synthesis of stearoylcarnitine from perfused palmitate

FEBS Letters ◽

10.1016/j.febslet.2007.08.026 ◽

2007 ◽

Vol 581 (23) ◽

pp. 4491-4494 ◽

Cited By ~ 6

Author(s):

Janos Kerner ◽

Paul E. Minkler ◽

Edward J. Lesnefsky ◽

Charles L. Hoppel

Keyword(s):

Fatty Acid ◽

Rat Heart ◽

Chain Elongation ◽

Perfused Rat Heart ◽

Fatty Acid Chain

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A mouse model of Long-Chain 3-Ketoacyl-CoA Thiolase deficlency of mitochondrial fatty acid beta-oxidation is associated with low body mass, cold intoterance and hepatic steatosis

Gastroenterology ◽

10.1016/s0016-5085(01)80526-6 ◽

2001 ◽

Vol 120 (5) ◽

pp. A107-A107

Author(s):

R MERRIMAN ◽

W QIN ◽

A STRAUSS

Keyword(s):

Fatty Acid ◽

Mouse Model ◽

Hepatic Steatosis ◽

Body Mass ◽

Beta Oxidation ◽

Mitochondrial Fatty Acid ◽

Fatty Acid Beta Oxidation ◽

Long Chain

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4-Bromocrotonic acid, an effective inhibitor of fatty acid oxidation and ketone body degradation in rat heart mitochondria. On the rate-determining step of beta-oxidation and ketone body degradation in heart.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)83791-2 ◽

1982 ◽

Vol 257 (10) ◽

pp. 5408-5413

Author(s):

Y Olowe ◽

H Schulz

Keyword(s):

Fatty Acid ◽

Fatty Acid Oxidation ◽

Rat Heart ◽

Ketone Body ◽

Heart Mitochondria ◽

Acid Oxidation ◽

Effective Inhibitor ◽

Beta Oxidation ◽

Rate Determining Step ◽

Rat Heart Mitochondria

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Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)32278-0 ◽

1994 ◽

Vol 269 (29) ◽

pp. 19088-19094

Author(s):

T. Aoyama ◽

I. Ueno ◽

T. Kamijo ◽

T. Hashimoto

Keyword(s):

Fatty Acid ◽

Chain Fatty Acid ◽

Beta Oxidation ◽

Long Chain Fatty Acid ◽

Dehydrogenase Gene ◽

Chain Acyl ◽

Fatty Acid Beta Oxidation ◽

Rate Limiting ◽

Oxidation System ◽

Long Chain

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Rat hepatic microsomal acetoacetyl-CoA reductase. A beta-ketoacyl-CoA reductase distinct from the long chain beta-ketoacyl-CoA reductase component of the microsomal fatty acid chain elongation system.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)42813-4 ◽

1984 ◽

Vol 259 (12) ◽

pp. 7460-7467

Author(s):

M R Prasad ◽

L Cook ◽

R Vieth ◽

D L Cinti

Keyword(s):

Fatty Acid ◽

Chain Elongation ◽

Fatty Acid Chain ◽

Coa Reductase ◽

Long Chain ◽

Acetoacetyl Coa Reductase

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The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results

Journal of Inherited Metabolic Disease ◽

10.1007/s10545-010-9104-8 ◽

2010 ◽

Vol 33 (5) ◽

pp. 479-494 ◽

Cited By ~ 113

Author(s):

Ronald J. A. Wanders ◽

Jos P. N. Ruiter ◽

Lodewijk IJlst ◽

Hans R. Waterham ◽

Sander M. Houten

Keyword(s):

Fatty Acid ◽

Neonatal Screening ◽

Beta Oxidation ◽

Mitochondrial Fatty Acid ◽

Fatty Acid Beta Oxidation

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Identification of possible intermediates in the mitochondrial fatty acid chain elongation system

Biochemistry ◽

10.1021/bi00812a017 ◽

1970 ◽

Vol 9 (10) ◽

pp. 2143-2152 ◽

Cited By ~ 14

Author(s):

Edward J. Barron ◽

Larry A. Mooney

Keyword(s):

Fatty Acid ◽

Chain Elongation ◽

Fatty Acid Chain ◽

Mitochondrial Fatty Acid

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