Modulation of Gastrointestinal Function by MuDelta, a mixed Mu Opioid Receptor Agonist/Delta Opioid Receptor Antagonist

A Novel Approach to Safer Analgesics: Mu Opioid Receptor Agonist & Delta Opioid Receptor Antagonist Peptidomimetics

The FASEB Journal ◽

10.1096/fasebj.2018.32.1_supplement.689.6 ◽

2018 ◽

Vol 32 (S1) ◽

Author(s):

Thomas Joaquín Fernández ◽

Nicholas Griggs ◽

Anthony Nastase ◽

Jessica Anand ◽

Emily J. Jutkiewicz ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Delta Opioid Receptor ◽

Mu Opioid ◽

Novel Approach ◽

Faculty Opinions recommendation of Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1086845.539776 ◽

2007 ◽

Author(s):

Howard Fields

Keyword(s):

Receptor Antagonist ◽

Conditioned Place Preference ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Place Preference ◽

Delta Opioid Receptor ◽

Bivalent Ligands ◽

Mu Opioid ◽

Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis

European Journal of Pharmacology ◽

10.1016/j.ejphar.2019.172702 ◽

2019 ◽

Vol 864 ◽

pp. 172702 ◽

Cited By ~ 8

Author(s):

Saadet Inan ◽

Alvaro Torres-Huerta ◽

Liselotte E. Jensen ◽

Nae J. Dun ◽

Alan Cowan

Keyword(s):

Contact Dermatitis ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Mu Opioid ◽

Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores

European Journal of Pharmacology ◽

10.1016/j.ejphar.2007.02.040 ◽

2007 ◽

Vol 566 (1-3) ◽

pp. 75-82 ◽

Cited By ~ 54

Author(s):

Natalie R. Lenard ◽

David J. Daniels ◽

Philip S. Portoghese ◽

Sandra C. Roerig

Keyword(s):

Receptor Antagonist ◽

Conditioned Place Preference ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Place Preference ◽

Delta Opioid Receptor ◽

Bivalent Ligands ◽

Mu Opioid ◽

244 Efficacy of kappa-opioid receptor agonist and mu-opioid receptor antagonist to treat itch in imiquimod-induced psoriasis-like dermatitis model

Journal of Investigative Dermatology ◽

10.1016/j.jid.2016.06.264 ◽

2016 ◽

Vol 136 (9) ◽

pp. S203

Author(s):

N. Takahashi ◽

M. Tominaga ◽

Y. Kamata ◽

Y. Umehara ◽

H. Matsuda ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Mu Opioid ◽

Receptor Binding Properties and Antinociceptive Effects of Chimeric Peptides Consisting of a μ-Opioid Receptor Agonist and an ORL1 Receptor Antagonist

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.30.1260 ◽

2007 ◽

Vol 30 (7) ◽

pp. 1260-1264 ◽

Cited By ~ 9

Author(s):

Susumu Kawano ◽

Risa Ito ◽

Miharu Nishiyama ◽

Mai Kubo ◽

Tomoko Matsushima ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Binding ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Binding Properties ◽

Mu Opioid ◽

Opioid Receptor Agonist ◽

Antinociceptive Effects ◽

Chimeric Peptides

Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist

British Journal of Pharmacology ◽

10.1111/j.1476-5381.2012.02068.x ◽

2012 ◽

Vol 167 (5) ◽

pp. 1111-1125 ◽

Cited By ~ 79

Author(s):

PR Wade ◽

JM Palmer ◽

S McKenney ◽

V Kenigs ◽

K Chevalier ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Gastrointestinal Function ◽

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.06.030 ◽

2015 ◽

Vol 25 (17) ◽

pp. 3716-3720 ◽

Cited By ~ 8

Author(s):

Padma Nair ◽

Takashi Yamamoto ◽

Scott Cowell ◽

Vinod Kulkarni ◽

Sharif Moye ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Neurokinin 1 Receptor ◽

Opioid Receptor Agonist ◽

Neurokinin 1 ◽

Multifunctional Ligands

Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents

Journal of Psychopharmacology ◽

10.1177/0269881116689257 ◽

2017 ◽

Vol 31 (6) ◽

pp. 730-739 ◽

Cited By ~ 76

Author(s):

Ahmad A Altarifi ◽

Bethany David ◽

Karan H Muchhala ◽

Bruce E Blough ◽

Hamid Akbarali ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Abuse Liability ◽

Repeated Treatment ◽

Gastrointestinal Function ◽

Mu Opioid ◽

Faculty Opinions recommendation of The selective mu-opioid receptor antagonist ADL5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in MPTP-lesioned macaque model of Parkinson's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9987957.10722055 ◽

2011 ◽

Author(s):

Alfredo Berardelli ◽

Antonio Suppa

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Receptor Antagonist ◽

Opioid Receptor ◽

Mu Opioid Receptor ◽

Mu Opioid ◽

Macaque Model ◽

Opioid Receptor Antagonist