scholarly journals Characterization of voltage‐operated and non‐voltage‐operated calcium channels in endothelin‐induced vasoconstriction of rat cerebral arteries (841.6)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Yohannes Mamo ◽  
James Ziogas ◽  
Paul Soeding ◽  
James Angus ◽  
Christine Wright
2014 ◽  
Vol 742 ◽  
pp. 65-73 ◽  
Author(s):  
Yohannes A. Mamo ◽  
James A. Angus ◽  
James Ziogas ◽  
Paul F. Soeding ◽  
Christine E. Wright

2006 ◽  
Vol 572 (3) ◽  
pp. 691-706 ◽  
Author(s):  
Sheila Vignali ◽  
Veronika Leiss ◽  
Rosi Karl ◽  
Franz Hofmann ◽  
Andrea Welling

1995 ◽  
Vol 68 (1) ◽  
pp. 1-34 ◽  
Author(s):  
Enrique Alborch ◽  
Juan B Salom ◽  
Germán Torregrosa

1993 ◽  
Vol 264 (2) ◽  
pp. H470-H478 ◽  
Author(s):  
J. M. Quayle ◽  
J. G. McCarron ◽  
J. R. Asbury ◽  
M. T. Nelson

Unitary currents through single calcium channels were measured from cell-attached patches on smooth muscle cells isolated from resistance-sized branches of posterior cerebral arteries from Wistar-Kyoto normotensive rats. Barium (80 and 10 mM) was used as the charge carrier, with and without the dihydropyridine calcium channel agonist BAY R 5417. Unitary currents decreased on membrane depolarization, with a slope conductance of 19.4 pS (80 mM barium). Channel open-state probability (Po) was steeply voltage dependent. Peak Po during test pulses from -70 mV increased e-fold per 4.5-mV depolarization. Mean peak Po at potentials positive to +10 mV was 0.44. Po at steady membrane potentials was also steeply voltage dependent, changing e-fold per 4.5 mV in the absence of inactivation. Steady-state Po at positive potentials was substantially lower than peak Po elicited by test pulses, suggesting that steady-state inactivation can reduce Po by as much as 10-fold. Membrane depolarization decreased the longest mean closed time but had little effect on the mean open time of single calcium channels measured during steady-state recordings. Lowering the external barium concentration from 80 to 10 mM reduced the single channel conductance to 12.4 pS and shifted the relationship between steady-state Po and membrane potential by about -30 mV. BAY R 5417 also shifted this relationship by about -15 mV.


1985 ◽  
Vol 39 ◽  
pp. 347
Author(s):  
Tetsuya Tsukahara ◽  
Takashi Taniguchi ◽  
Shun Shimohama ◽  
Motohatsu Fujiwara

2003 ◽  
Vol 18 (2) ◽  
pp. 1-17 ◽  
Author(s):  
Fortunata Barone ◽  
Salvatore Aguanno ◽  
Alessio D'Alessio ◽  
Angela D'Agostino

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