scholarly journals (−)‐Epigallocatechin‐3‐Gallate Protects against TNF alpha and Hydrogen Peroxide Induced Apoptosis in a Cell Culture Model of Parkinson's Disease

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Qi Xu ◽  
Anumantha Kanthasamy ◽  
Manju Reddy
Keyword(s):  
Parkinson’S Disease ◽  
Hydrogen Peroxide ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Tnf Alpha ◽  
Cell Culture Model ◽  
Culture Model ◽  
A Cell ◽  
Induced Apoptosis

Dissecting Comorbidity between Parkinson’s Disease and Melanoma in a Cell Culture Model

2017 ◽  
Vol 31 (1_supplement) ◽  
pp. 631.1-631.1 ◽  
Author(s):  
Anindita Bose ◽  
Deborah Dele-Oni ◽  
Gregory Petsko
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Cell Culture Model ◽  
Culture Model ◽  
A Cell

FAAH INHIBITION IS PROTECTIVE IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE

2012 ◽  
Vol 83 (Suppl 2) ◽  
pp. A15.1-A15 ◽  
Author(s):  
M Zeissler ◽  
CO Hanemann ◽  
JP Zajicek ◽  
CB Carroll
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Cell Culture Model ◽  
Culture Model ◽  
A Cell ◽  
Faah Inhibition

ENDOCANNABINOID TOXICITY IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE

2012 ◽  
Vol 83 (Suppl 2) ◽  
pp. A13.4-A14
Author(s):  
E Salter ◽  
ML Zeissler ◽  
SPH Alexander ◽  
CO Hanemann ◽  
JP Zajicek ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Cell Culture Model ◽  
Culture Model ◽  
A Cell

scholarly journals Microglial responses to dopamine in a cell culture model of Parkinson's disease

2009 ◽  
Vol 30 (11) ◽  
pp. 1805-1817 ◽  
Author(s):  
Diego Mastroeni ◽  
Andrew Grover ◽  
Brian Leonard ◽  
Jeffrey N. Joyce ◽  
Paul D. Coleman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Cell Culture Model ◽  
Culture Model ◽  
A Cell ◽  
Responses To Dopamine

scholarly journals Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Qi Xu ◽  
Anumantha G. Kanthasamy ◽  
Huajun Jin ◽  
Manju B. Reddy
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Cell Culture Model ◽  
Intracellular Iron ◽  
Cellular Iron ◽  
Ferroportin 1 ◽  
Culture Model ◽  
A Cell ◽  
Induced Apoptosis

Background. Elevated brain iron levels have been implicated in the pathogenesis of Parkinson’s disease (PD). However, the precise mechanism underlying abnormal iron accumulation in PD is not clear. Hepcidin, a hormone primarily produced by hepatocytes, acts as a key regulator in both systemic and cellular iron homeostasis.Objective. We investigated the role of hepcidin in 6-hydroxydopamine (6-OHDA) induced apoptosis in a cell culture model of PD.Methods. We downregulated hepcidin using siRNA interference in N27 dopaminergic neuronal cells and made a comparison with control siRNA transfected cells to investigate the role of hepcidin in 6-OHDA induced neurodegeneration.Results. Hepcidin knockdown (32.3%,P<0.0001) upregulated ferroportin 1 expression and significantly (P<0.05) decreased intracellular iron by 25%. Hepcidin knockdown also reduced 6-OHDA induced caspase-3 activity by 42% (P<0.05) and DNA fragmentation by 29% (P=0.086) and increased cell viability by 22% (P<0.05). In addition, hepcidin knockdown significantly attenuated 6-OHDA induced protein carbonyls by 52% (P<0.05) and intracellular iron by 28% (P<0.01), indicating the role of hepcidin in oxidative stress.Conclusions. Our results demonstrate that hepcidin knockdown protected N27 cells from 6-OHDA induced apoptosis and that hepcidin plays a major role in reducing cellular iron burden and oxidative damage by possibly regulating cellular iron export mediated by ferroportin 1.

scholarly journals Δ9–TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPARγ DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE

2013 ◽  
Vol 84 (11) ◽  
pp. e2.58-e2 ◽  
Author(s):  
Marie–Louise Zeissler ◽  
Jordan Eastwood ◽  
C Oliver Hanemann ◽  
John Zajicek ◽  
Camille Carroll
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Mitochondrial Biogenesis ◽  
Cell Culture Model ◽  
Culture Model ◽  
A Cell
Sign in / Sign up

Export Citation Format

Share Document