scholarly journals Cutinase‐like proteins of Mycobacterium tuberculosis : characterization of their variable enzymatic functions and active site identification

2009 ◽  
Vol 23 (6) ◽  
pp. 1694-1704 ◽  
Author(s):  
Nicholas P. West ◽  
Frances M. E. Chow ◽  
Elizabeth J. Randall ◽  
Jing Wu ◽  
Jian Chen ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Active Site ◽  
Site Identification

Characterization of an Abnormal Antithrombin (Milano 2) with Defective Thrombin Binding

1986 ◽  
Vol 56 (03) ◽  
pp. 349-352 ◽  
Author(s):  
A Tripodi ◽  
A Krachmalnicoff ◽  
P M Mannucci
Keyword(s):  
Venous Thromboembolism ◽  
Active Site ◽  
Inhibitory Activity ◽  
Antithrombin Iii ◽  
Factor Xa ◽  
Molecular Defect ◽  
Affinity Adsorption ◽  
Italian Family ◽  
Crossed Immunoelectrophoresis

SummaryFour members of an Italian family (two with histories of venous thromboembolism) had a qualitative defect of antithrombin III reflected by normal antigen concentrations and halfnormal antithrombin activity with or without heparin. Anti-factor Xa activities were consistently borderline low (about 70% of normal). For the propositus’ plasma and serum the patterns of antithrombin III in crossed-immunoelectrophoresis with or without heparin were indistinguishable from those of normal plasma or serum. A normal affinity of antithrombin III for heparin was documented by heparin-sepharose chromatography. Affinity adsorption of the propositus’ plasma to human α-thrombin immobilized on sepharose beads revealed defective binding of the anti thrombin III to thrombin-sepharose. Hence the molecular defect of this variant appears to be at the active site responsible for binding and neutralizing thrombin, thus accounting for the low thrombin inhibitory activity.

scholarly journals Structural Characterization of Two CO Molecules Bound to the Nitrogenase Active Site

2020 ◽  
Author(s):  
Trixia M. Buscagan ◽  
Kathryn A. Perez ◽  
Ailiena O. Maggiolo ◽  
Douglas C. Rees ◽  
Thomas Spatzal
Keyword(s):  
Structural Characterization ◽  
Active Site

scholarly journals Characterization of Light-Induced, Short-Lived Interacting Radicals in the Active Site of Flavoprotein Ferredoxin-NADP+ Oxidoreductase

2021 ◽  
Vol 143 (7) ◽  
pp. 2757-2768
Author(s):  
Bo Zhuang ◽  
Daisuke Seo ◽  
Alexey Aleksandrov ◽  
Marten H. Vos
Keyword(s):  
Active Site

scholarly journals Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.

1990 ◽  
Vol 265 (4) ◽  
pp. 2038-2041
Author(s):  
C G Wilde ◽  
J L Snable ◽  
J E Griffith ◽  
R W Scott
Keyword(s):  
Active Site ◽  
Neutrophil Elastase

scholarly journals Characterization of the putative tryptophan synthase β-subunit from Mycobacterium tuberculosis

2009 ◽  
Vol 41 (5) ◽  
pp. 379-388 ◽  
Author(s):  
Hongbo Shen ◽  
Yanping Yang ◽  
Feifei Wang ◽  
Ying Zhang ◽  
Naihao Ye ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tryptophan Synthase ◽  
Β Subunit
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