scholarly journals 37/67‐laminin receptor facilitates neural crest cell migration during enteric nervous system development

2020 ◽  
Vol 34 (8) ◽  
pp. 10931-10947
Author(s):  
Ming Fu ◽  
Amanda J. Barlow‐Anacker ◽  
Korah P. Kuruvilla ◽  
Gary L. Bowlin ◽  
Christopher W. Seidel ◽  
...  
Keyword(s):  
Nervous System ◽  
Cell Migration ◽  
Enteric Nervous System ◽  
System Development ◽  
Neural Crest Cell ◽  
Nervous System Development ◽  
Laminin Receptor ◽  
Neural Crest Cell Migration ◽  
Crest Cell ◽  
Enteric Nervous System Development

scholarly journals BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system

2005 ◽  
Vol 122 (6) ◽  
pp. 821-833 ◽  
Author(s):  
Allan M. Goldstein ◽  
Katherine C. Brewer ◽  
Adele M. Doyle ◽  
Nandor Nagy ◽  
Drucilla J. Roberts
Keyword(s):  
Nervous System ◽  
Cell Migration ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
Neural Crest Cell ◽  
Bmp Signaling ◽  
Neural Crest Cell Migration ◽  
Crest Cell

Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis

Development ◽  
2002 ◽  
Vol 129 (22) ◽  
pp. 5151-5160 ◽  
Author(s):  
Dipa Natarajan ◽  
Camelia Marcos-Gutierrez ◽  
Vassilis Pachnis ◽  
Esther de Graaff
Keyword(s):  
Nervous System ◽  
Cell Migration ◽  
Tyrosine Kinase ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
Receptor Tyrosine Kinase ◽  
Neural Crest Cell ◽  
Neural Crest Cell Migration ◽  
Crest Cell

The majority of neurones and glia of the enteric nervous system (ENS) are derived from the vagal neural crest. Shortly after emigration from the neural tube, ENS progenitors invade the anterior foregut and, migrating in a rostrocaudal direction, colonise in an orderly fashion the rest of the foregut, the midgut and the hindgut. We provide evidence that activation of the receptor tyrosine kinase RET by glial cell line-derived neurotrophic factor (GDNF) is required for the directional migration of ENS progenitors towards and within the gut wall. We find that neural crest-derived cells present within foetal small intestine explants migrate towards an exogenous source of GDNF in a RET-dependent fashion. Consistent with an in vivo role of GDNF in the migration of ENS progenitors, we demonstrate that Gdnf is expressed at high levels in the gut of mouse embryos in a spatially and temporally regulated manner. Thus, during invasion of the foregut by vagal-derived neural crest cells, expression of Gdnf was restricted to the mesenchyme of the stomach, ahead of the invading NC cells. Twenty-four hours later and as the ENS progenitors were colonising the midgut,Gdnf expression was upregulated in a more posterior region —the caecum anlage. In further support of a role of endogenous GDNF in enteric neural crest cell migration, we find that in explant cultures GDNF produced by caecum is sufficient to attract NC cells residing in more anterior gut segments. In addition, two independently generated loss-of-function alleles of murine Ret, Ret.k— and miRet51, result in characteristic defects of neural crest cell migration within the developing gut. Finally, we identify phosphatidylinositol-3 kinase and the mitogen-activated protein kinase signalling pathways as playing crucial roles in the migratory response of enteric neural crest cells to GDNF.

scholarly journals Changes in Nicotinic Neurotransmission during Enteric Nervous System Development

2015 ◽  
Vol 35 (18) ◽  
pp. 7106-7115 ◽  
Author(s):  
J. P. P. Foong ◽  
C. S. Hirst ◽  
M. M. Hao ◽  
S. J. McKeown ◽  
W. Boesmans ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
System Development ◽  
Nervous System Development ◽  
Enteric Nervous System Development

scholarly journals Testing the Ret and Sema3d genetic interaction in mouse enteric nervous system development

2017 ◽  
Vol 26 (10) ◽  
pp. 1811-1820 ◽  
Author(s):  
Ashish Kapoor ◽  
Dallas R. Auer ◽  
Dongwon Lee ◽  
Sumantra Chatterjee ◽  
Aravinda Chakravarti
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Genetic Interaction ◽  
System Development ◽  
Nervous System Development ◽  
Enteric Nervous System Development
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