Granular Cell Basal Cell Carcinoma and Granular Cell Tumor-Light Microscopic and Immunohistochemical Comparison.

The clinical, microscopic, and gross features of 36 cases of benign granular cell tumor arising in the larynx are reviewed and studied. This infrequent lesion, when in the larynx, is found most commonly on the true vocal cord in adults in their third, fourth, and fifth decades; there is no obvious sex predilection. Slowly increasing hoarseness was the primary complaint in our cases. Clinically, the tumors are considered benign. The most common clinical impression was a vocal cord papilloma. The microscopic pattern of the granular cell tumors is uniform and bland, but there may be a marked pseudoepitheliomatous hyperplasia of the overlying squamous epithelium, often stimulating squamous cell carcinoma. Follow-up information is discussed, as is the origin and histogenesis of this lesion.

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Coexistent Squamous Cell Carcinoma and Granular Cell Tumor of Head and Neck Region: Report of Two Very Rare Cases and Review of the Literature

International Journal of Surgical Pathology ◽

10.1177/1066896917724513 ◽

2017 ◽

Vol 26 (1) ◽

pp. 47-51 ◽

Cited By ~ 2

Author(s):

Danila Caroppo ◽

Grazia Salerno ◽

Francesco Merolla ◽

Massimo Mesolella ◽

Gennaro Ilardi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Granular Cell Tumor ◽

Neck Region ◽

Granular Cell ◽

Cell Tumor ◽

Head And Neck Region ◽

Pathologic Features

Granular cell tumor (GCT), a relatively rare neuroectodermal tumor occurring most often in the head and neck region, is not uncommonly associated with pseudoepitheliomatous hyperplasia of the overlying surface epithelium, which may be at times nonreadily distinguishable from well-differentiated squamous cell carcinoma (SCC). To the best of our knowledge, only a handful of coexisting SCC and GCT, mostly described in the esophagus, have been reported in (the current) literature so far. We herein report 2 new cases of coexisting GCT and SCC of the head and neck region, located, respectively, in larynx and tongue; comment on their clinical, imaging, and pathologic features; and discuss their management. In the present work, we also review the literature concerning this association to contribute to the head and neck pathologists’ and surgeons’ awareness regarding the possibility of this association for an adequate surgical excision and a better management of these patients.

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Squamous cell carcinoma associated granular cell tumor with progressive FDG accumulation

International Journal of Medical Reviews and Case Reports ◽

10.5455/ijmrcr.granular-cell-tumor-fdg-uptake ◽

2019 ◽

pp. 1

Author(s):

Zehra Koc ◽

Pelin Kara ◽

Emel Sezer ◽

Cengiz Özcan ◽

Mehmet Yaldız ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Fdg Accumulation

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Granular Cell Tumors of the Larynx

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348947608500411 ◽

1976 ◽

Vol 85 (4) ◽

pp. 504-507 ◽

Cited By ~ 5

Author(s):

Harvey L. Coates ◽

Thomas J. McDonald ◽

Kenneth D. Devine ◽

Louis H. Weiland

Keyword(s):

Squamous Cell Carcinoma ◽

Differential Diagnosis ◽

Cell Carcinoma ◽

Local Excision ◽

Squamous Cell ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Posterior Portion ◽

Pseudoepitheliomatous Hyperplasia

Granular cell tumors of the larynx are relatively uncommon, always benign, and most commonly located in the posterior portion of the larynx. They are easily identified and should be differentiated from other lesions. A possible problem in the differential diagnosis is the presence of pseudoepitheliomatous hyperplasia, which overlies the granular cell tumor and which may mimic squamous cell carcinoma. Careful histopathologic differentiation is important because the laryngeal granular cell lesion should be managed conservatively, with transoral local excision usually being adequate. The histogenesis of these lesions remains in doubt, with a neural or epithelial derivation being the most likely possibility.

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