NEUROMUSCULAR BLOCKADE MONITORING IN PEDIATRIC PATIENTS

2000 ◽  
Vol 100 (12) ◽  
pp. 24HH
Author(s):  
&NA;
Keyword(s):  
Neuromuscular Blockade ◽  
Pediatric Patients

Sugammadex for reversal of neuromuscular blockade in pediatric patients: results from a phase IV randomized study

2021 ◽  
Author(s):  
Tiffini Voss ◽  
Aobo Wang ◽  
Matthew DeAngelis ◽  
Marcel Speek ◽  
Vera Saldien ◽  
...  
Keyword(s):  
Neuromuscular Blockade ◽  
Pediatric Patients ◽  
Randomized Study ◽  
Phase Iv

scholarly journals Neuromuscular blockade in children

2000 ◽  
Vol 55 (3) ◽  
pp. 105-110 ◽  
Author(s):  
João Fernando Lourenço de Almeida ◽  
W. Jorge Kalil Filho ◽  
Eduardo J. Troster
Keyword(s):  
Mechanical Ventilation ◽  
Neuromuscular Junction ◽  
Neuromuscular Blockade ◽  
Continuous Improvement ◽  
Pediatric Patients ◽  
Invasive Procedure ◽  
Medical Intervention ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
The Many

Neuromuscular blocking agents (NMBAs) have been widely used to control patients who need to be immobilized for some kind of medical intervention, such as an invasive procedure or synchronism with mechanical ventilation. The purpose of this monograph is to review the pharmacology of the NMBAs, to compare the main differences between the neuromuscular junction in neonates, infants, toddlers and adults, and moreover to discuss their indications in critically ill pediatric patients. Continuous improvement of knowledge about NMBAs pharmacology, adverse effects, and the many other remaining unanswered questions about neuromuscular junction and neuromuscular blockade in children is essential for the correct use of these drugs. Therefore, the indication of these agents in pediatrics is determined with extreme judiciousness. Computorized (Medline 1990-2000) and active search of articles were the mechanisms used in this review.

scholarly journals Sugammadex: Applications in Pediatric Critical Care

2020 ◽  
Vol 09 (03) ◽  
pp. 162-171
Author(s):  
Joseph D. Tobias
Keyword(s):  
Neuromuscular Blockade ◽  
Pediatric Patients ◽  
Pediatric Population ◽  
Acetylcholinesterase Inhibitor ◽  
Pediatric Intensive Care ◽  
Acetylcholinesterase Inhibitors ◽  
Intensive Care Unit Population ◽  
Pharmacologic Agent ◽  
Complete Reversal ◽  
Prospective Trials

AbstractSugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade with a mechanism that differs from acetylcholinesterase inhibitors such as neostigmine. There is a growing body of literature demonstrating its efficacy in pediatric patients of all ages. Prospective trials have demonstrated a more rapid and more complete reversal of rocuronium-induced neuromuscular blockade than the acetylcholinesterase inhibitor, neostigmine. Unlike the acetylcholinesterase inhibitors, sugammadex effectively reverses intense or complete neuromuscular blockade. It may also be effective in situations where reversal of neuromuscular blockade is problematic including patients with neuromyopathic conditions or when acetylcholinesterase inhibitors are contraindicated. This article reviews the physiology of neuromuscular transmission as well as the published literature, regarding the use of sugammadex in pediatric population including the pediatric intensive care unit population. Clinical applications are reviewed, adverse effects are discussed, and dosing algorithms are presented.

scholarly journals Sedation, Analgesia, and Neuromuscular Blockade: An Assessment of Practices From 2009 to 2016 in a National Sample of 66,443 Pediatric Patients Cared for in the ICU*

2020 ◽  
Vol 21 (9) ◽  
pp. e599-e609 ◽  
Author(s):  
Anita K. Patel ◽  
Eduardo Trujillo-Rivera ◽  
Farhana Faruqe ◽  
Julia A. Heneghan ◽  
T. Elizabeth Workman ◽  
...  
Keyword(s):  
Neuromuscular Blockade ◽  
Pediatric Patients ◽  
National Sample

scholarly journals Sugammadex for reversal of rocuronium-induced neuromuscular blockade in pediatric patients

Medicine ◽  
2016 ◽  
Vol 95 (34) ◽  
pp. e4678 ◽  
Author(s):  
Young Ju Won ◽  
Byung Gun Lim ◽  
Dong Kyu Lee ◽  
Heezoo Kim ◽  
Myoung Hoon Kong ◽  
...  
Keyword(s):  
Neuromuscular Blockade ◽  
Pediatric Patients

scholarly journals ASSESSMENT OF ROCURONIUM EFFECTIVENESS FOR PAITENTS

2020 ◽  
Vol 1 (2) ◽  
pp. 26-31
Author(s):  
Marcelo Luiz Lima
Keyword(s):  
Neuromuscular Blockade ◽  
Muscle Relaxant ◽  
Time Course ◽  
Pediatric Patients ◽  
Muscle Relaxants ◽  
Twitch Response ◽  
Intubating Conditions ◽  
Maximal Stimulation ◽  
Age Category ◽  
Stimulation Of

The study is based on succinylcholine which is a routine muscle relaxant for pediatric patients. Rocuronium is newer non depolarizing muscle relaxant. The objective of this study was to assess time, course and duration of both relaxants as well as intubation conditions. This study was blind and randomized in nature and conducted to test the intubating conditions with two separate kind of muscle relaxants in 50 ASA grade I and II pediatric patients who fall in age category of 2 to 6 years who undergone surgery of less than half an hour. Patients were anaesthetized with injection rocuronium 0.9 mg/kg i.v. or with injection succinylcholine 1.5 mg/kg after injection fentanyl 1ug/kg and injection thiopentone 5 mg/kg. The assessment of Neuromuscular blockade was conducted with twitch response of adductor pollicis longus after supra-maximal stimulation of ulnar nerve. We assessed Tracheal intubating conditions using the blinded anesthetist after 1 month and every 15 seconds till patient got intubated. The time of onset and percentage of neuromuscular blockage was also assessed.

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