scholarly journals The effect of neuromuscular blockade on oxygen consumption in sedated and mechanically ventilated pediatric patients after cardiac surgery

2008 ◽  
Vol 34 (12) ◽  
pp. 2268-2272 ◽  
Author(s):  
J. Lemson ◽  
J. J. Driessen ◽  
J. G. van der Hoeven
1997 ◽  
Vol 12 (6) ◽  
pp. 321-323
Author(s):  
Robert L. Sheridan ◽  
Kathy Prelack ◽  
Stanislaw K. Szyfelbein

Minimizing the high oxygen consumption and energy expenditure of the critically ill is an important therapeutic goal. This study was done to determine if neuromuscular blockade decreases oxygen consumption or energy expenditure more than sedation alone in the mechanically ventilated child. Twelve burned children, with an average age of 5.1- 1.6 yrs, average weight of 22.8 − 6.5 kg, and average burn size of 28.3 − 5.8% of the body surface, scheduled for a planned surgical procedure under general anesthesia were enrolled in this prospective self-controlled study. In conjunction with planned operative procedures and using an intravenous anesthetic technique, the children underwent expired gas collection before and after neuromuscular blockade was induced. Expired gas was collected and analyzed for the fractional concentration of oxygen and carbon dioxide. Oxygen consumption (VO2), carbon dioxide production (VCO2), energy expenditure (EE), and respiratory quotient (RQ) were calculated. We found no significant difference in EE, VO2, VCO2, or RQ between the well-sedated and mechanically ventilated and the well-sedated, mechanically ventilated and paralyzed states. We therefore concluded that neuromuscular blockade does not decrease energy expenditure in the otherwise well-sedated burned child.


Author(s):  
Chalattil Bipin ◽  
Manoj K. Sahu ◽  
Sarvesh P. Singh ◽  
Velayoudam Devagourou ◽  
Palleti Rajashekar ◽  
...  

Abstract Objectives This study was aimed to assess the benefits of early tracheostomy (ET) compared with late tracheostomy (LT) on postoperative outcomes in pediatric cardiac surgical patients. Design Present one is a prospective, observational study. Setting The study was conducted at a cardiac surgical intensive care unit (ICU) of a tertiary care hospital. Participants All pediatric patients below 10 years of age, who underwent tracheostomy after cardiac surgery from January2019 to december2019, were subdivided into two groups according to the timing of tracheostomy: “early” if done before 7 days or “late” if done after 7 days postcardiac surgery. Interventions ET versus LT was measured in the study. Results Out of all 1,084 pediatric patients who underwent cardiac surgery over the study period, 41 (3.7%) received tracheostomy. Sixteen (39%) patients underwent ET and 25 (61%) underwent LT. ET had advantages by having reduced risk associations with the following variables: preoperative hospital stay (p = 0.0016), sepsis (p = 0.03), high risk surgery (p = 0.04), postoperative sepsis (p = 0.001), C-reactive protein (p = 0.04), ventilator-associated pneumonia (VAP; p = 0.006), antibiotic escalation (p = 0.006), and antifungal therapy (p = 0.01) requirement. Furthermore, ET was associated with lesser duration of mechanical ventilation (p = 0.0027), length of ICU stay (LOICUS; p = 0.01), length of hospital stay (LOHS; p = 0.001), lesser days of feed interruption (p = 0.0017), and tracheostomy tube change (p = 0.02). ET group of children, who had higher total ventilation-free days (p = 0.02), were decannulated earlier (p = 0.03) and discharged earlier (p = 0.0089). Conclusion ET had significant benefits in reduction of postoperative morbidities with overall shorter mechanical ventilation, LOICUS, and LOHS, better nutrition supplementation, lesser infection, etc. These benefits may promote faster patient convalescence and rehabilitation with reduced hospital costs.


Critical Care ◽  
2009 ◽  
Vol 13 (5) ◽  
pp. R164 ◽  
Author(s):  
Tarek A Abdel-Gawad ◽  
Mostafa A El-Hodhod ◽  
Hanan M Ibrahim ◽  
Yousef W Michael

2000 ◽  
Vol 83 (01) ◽  
pp. 54-59 ◽  
Author(s):  
Elena Levin ◽  
John Wu ◽  
John Alexander ◽  
Clayton Reichart ◽  
Suvro Sett ◽  
...  

SummaryWe have investigated hemostatic parameters including platelet activation in 56 pediatric patients with or without cyanosis undergoing cardiopulmonary bypass (CPB) and cardiac surgery to repair congenital defects. Patients were participants in a study assessing the effects of tranexamic acid on surgery-related blood loss. Parameters monitored included blood loss, prothrombin F1.2, thrombin-antithrombin complexes, t-PA, PAI-1, plasminogen, fibrin D-dimer, and plasma factor XIII. Additionally, flow cytometry monitored platelet degranulation (P-selectin or CD63), as well as surface-bound fibrinogen, von Willebrand factor and factor XIIIa. Cyanotic patients had evidence of supranormal coagulation activation as both fibrin D-dimer and PAI-1 levels were elevated prior to surgery. While the extent of expression of Pselectin or CD63 was not informative, platelet-associated factor XIIIa was elevated in cyanotic patients at baseline. In both patient groups, CPB altered platelet activation state and coagulation status irrespective of the use of tranexamic acid.


2016 ◽  
Vol 60 (4) ◽  
pp. 142-143
Author(s):  
Martha A. Q. Curley ◽  
David Wypij ◽  
R. Scott Watson ◽  
Mary Jo C. Grant ◽  
Lisa A. Asaro ◽  
...  

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