The Direct Effects of Heparin and Protamine on Canine Tracheal Smooth Muscle Tone

1999 ◽  
Vol 88 (6) ◽  
pp. 1232-1238
Author(s):  
Michiaki Yamakage ◽  
Takashi Matsuzaki ◽  
Naoki Tsujiguchi ◽  
Tomohisa Mori ◽  
Akiyoshi Namiki
1999 ◽  
Vol 88 (6) ◽  
pp. 1232-1238 ◽  
Author(s):  
Michiaki Yamakage ◽  
Takashi Matsuzaki ◽  
Naoki Tsujiguchi ◽  
Tomohisa Mori ◽  
Akiyoshi Namiki

2007 ◽  
Vol 556 (1-3) ◽  
pp. 151-156 ◽  
Author(s):  
Katsuyuki Kojima ◽  
Hiroaki Kume ◽  
Satoru Ito ◽  
Tetsuya Oguma ◽  
Akira Shiraki ◽  
...  

1986 ◽  
Vol 20 (6) ◽  
pp. 492-495 ◽  
Author(s):  
Vinod K Bhutani ◽  
Randy J Koslo ◽  
Thomas H Shaffer

1986 ◽  
Vol 64 (3) ◽  
pp. 351-363 ◽  
Author(s):  
Musa A. Haxhui ◽  
E.Chandler Deal ◽  
Matthew P. Norcia ◽  
Erik Van Lunteren ◽  
Jyoti Mitra ◽  
...  

1989 ◽  
Vol 67 (3) ◽  
pp. 1256-1264 ◽  
Author(s):  
S. E. Webber ◽  
R. O. Salonen ◽  
M. E. Deffebach ◽  
J. G. Widdicombe

The effects of Ascaris suum antigen on tracheal circulation and tracheal smooth muscle tone were compared in two groups of sheep: the first group was 1 yr old (14 sheep) and the second 5 yr old (8 sheep). Cranial tracheal arteries of anesthetized and paralyzed sheep were perfused at constant flow with monitoring of perfusion pressure. Tracheal smooth muscle tone was assessed by measuring changes in the external diameter of the cranial trachea. Close-arterial injection of antigen (1–20 micrograms) in young sheep produced dose-dependent vasodilation (6.1–15.5% fall in perfusion pressure) and smooth muscle contraction (0.06–0.28 mm reduction in tracheal diam). In old sheep, antigen (1–20 micrograms) produced vasoconstriction (4.1–16.8%) but no smooth muscle response. The smooth muscle contraction in young sheep was blocked by mepyramine (2 mg/kg iv) suggesting mediation by release of histamine. The vasodilation in young sheep and the vasoconstriction in old sheep were reduced by indomethacin (5 mg/kg iv), and the residual response was further reduced by FPL 55712 (2 mg/kg iv), suggesting mediation by both cyclooxygenase products and leukotrienes. Thus antigen given in the tracheal vasculature releases a mixture of inflammatory mediators. This mixture of mediators or their actions on the tracheal vasculature and smooth muscle may depend on the age of the sheep.


1996 ◽  
Vol 60 (3) ◽  
pp. 136-140 ◽  
Author(s):  
Iunis Suzuki ◽  
Tetsuri Kondo ◽  
Yutaka Hirokawa ◽  
Yasuyo Ohta ◽  
Hideho Arita

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