EVIDENCE THAT TRACHEAL SMOOTH MUSCLE TONE IN GUINEA-PIG IS UNAFFECTED BY OVERFLOW OF NORADRENALINE RELEASED BY PERIVASCULAR NERVE FIBRES

Histamine produces constriction of tracheal smooth muscle via H1 receptors, but it also decreases tracheal smooth muscle tone via H2 and H3 receptors. In addition, it has already been reported that phenylethylamine is competitive antagonist of histamine N-methyl-transferase (HMT), enzyme responsible for rapid inactivation of histamine. Our results suggest possibility that phenylethylamine as competitive antagonist of histamine N-methyl-transferase leads to potentiation of histamine induced constriction of isolated guinea-pig trachea, which could be consequence of decreased histamine methylation and subsequent histamine inactivation. At the same time, phenylethylamine had no direct effect on basal tone of intact isolated trachea rings, as well as on other mechanisms leading to increased responsiveness of guinea-pig tracheal smooth muscle (acetylcholine, KCl, electro stimulation).

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Medullary effects of nicotine and GABA on tracheal smooth muscle tone

Respiration Physiology ◽

10.1016/0034-5687(86)90128-3 ◽

1986 ◽

Vol 64 (3) ◽

pp. 351-363 ◽

Cited By ~ 36

Author(s):

Musa A. Haxhui ◽

E.Chandler Deal ◽

Matthew P. Norcia ◽

Erik Van Lunteren ◽

Jyoti Mitra ◽

...

Keyword(s):

Smooth Muscle ◽

Muscle Tone ◽

Tracheal Smooth Muscle ◽

Smooth Muscle Tone

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The Direct Effects of Heparin and Protamine on Canine Tracheal Smooth Muscle Tone

Anesthesia & Analgesia ◽

10.1097/00000539-199906000-00009 ◽

1999 ◽

Vol 88 (6) ◽

pp. 1232-1238

Author(s):

Michiaki Yamakage ◽

Takashi Matsuzaki ◽

Naoki Tsujiguchi ◽

Tomohisa Mori ◽

Akiyoshi Namiki

Keyword(s):

Smooth Muscle ◽

Muscle Tone ◽

Tracheal Smooth Muscle ◽

Direct Effects ◽

Smooth Muscle Tone

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Non-adrenergic, non-cholinergic neural activation stabilizes smooth-muscle tone independently of eicosanoid factors in guinea-pig isolated airways

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1991.tb12459.x ◽

1991 ◽

Vol 104 (2) ◽

pp. 509-513 ◽

Cited By ~ 6

Author(s):

A. Lindén ◽

A. Ullman ◽

C-G. Löfdahl ◽

B-E. Skoogh

Keyword(s):

Smooth Muscle ◽

Guinea Pig ◽

Muscle Tone ◽

Neural Activation ◽

Smooth Muscle Tone

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Effects of antigen on tracheal circulation and smooth muscle in sheep of different ages

Journal of Applied Physiology ◽

10.1152/jappl.1989.67.3.1256 ◽

1989 ◽

Vol 67 (3) ◽

pp. 1256-1264 ◽

Cited By ~ 4

Author(s):

S. E. Webber ◽

R. O. Salonen ◽

M. E. Deffebach ◽

J. G. Widdicombe

Keyword(s):

Smooth Muscle ◽

Muscle Contraction ◽

Perfusion Pressure ◽

Muscle Tone ◽

Smooth Muscle Contraction ◽

Tracheal Smooth Muscle ◽

External Diameter ◽

Smooth Muscle Tone ◽

Residual Response ◽

Dose Dependent

The effects of Ascaris suum antigen on tracheal circulation and tracheal smooth muscle tone were compared in two groups of sheep: the first group was 1 yr old (14 sheep) and the second 5 yr old (8 sheep). Cranial tracheal arteries of anesthetized and paralyzed sheep were perfused at constant flow with monitoring of perfusion pressure. Tracheal smooth muscle tone was assessed by measuring changes in the external diameter of the cranial trachea. Close-arterial injection of antigen (1–20 micrograms) in young sheep produced dose-dependent vasodilation (6.1–15.5% fall in perfusion pressure) and smooth muscle contraction (0.06–0.28 mm reduction in tracheal diam). In old sheep, antigen (1–20 micrograms) produced vasoconstriction (4.1–16.8%) but no smooth muscle response. The smooth muscle contraction in young sheep was blocked by mepyramine (2 mg/kg iv) suggesting mediation by release of histamine. The vasodilation in young sheep and the vasoconstriction in old sheep were reduced by indomethacin (5 mg/kg iv), and the residual response was further reduced by FPL 55712 (2 mg/kg iv), suggesting mediation by both cyclooxygenase products and leukotrienes. Thus antigen given in the tracheal vasculature releases a mixture of inflammatory mediators. This mixture of mediators or their actions on the tracheal vasculature and smooth muscle may depend on the age of the sheep.

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