Online Monitoring of Air Quality at the Postanesthetic Care Unit by Proton-Transfer-Reaction Mass Spectrometry

2001 ◽  
pp. 389-392 ◽  
Author(s):  
Josef Rieder ◽  
Peter Prazeller ◽  
Michael Boehler ◽  
Philipp Lirk ◽  
Werner Lindinger ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Air Quality ◽  
Proton Transfer ◽  
Transfer Reaction ◽  
Online Monitoring ◽  
Proton Transfer Reaction ◽  
Reaction Mass ◽  
Postanesthetic Care Unit

Online Monitoring of Air Quality at the Postanesthetic Care Unit by Proton-Transfer-Reaction Mass Spectrometry

2001 ◽  
Vol 92 (2) ◽  
pp. 389-392 ◽  
Author(s):  
Josef Rieder ◽  
Peter Prazeller ◽  
Michael Boehler ◽  
Philipp Lirk ◽  
Werner Lindinger ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Air Quality ◽  
Proton Transfer ◽  
Transfer Reaction ◽  
Online Monitoring ◽  
Proton Transfer Reaction ◽  
Reaction Mass ◽  
Postanesthetic Care Unit

Online monitoring of air quality at the postanaesthetic care unit by proton-transfer-reaction mass spectrometry

2001 ◽  
Vol 18 (Supplement 21) ◽  
pp. 28
Author(s):  
P. Lirk ◽  
G. Summer ◽  
P. Prazeller ◽  
A. Amann ◽  
J. Rieder
Keyword(s):  
Mass Spectrometry ◽  
Air Quality ◽  
Proton Transfer ◽  
Transfer Reaction ◽  
Online Monitoring ◽  
Proton Transfer Reaction ◽  
Reaction Mass

Spray Inlet Proton Transfer Reaction Mass Spectrometry (SI-PTR-MS) for Rapid and Sensitive Online Monitoring of Benzene in Water

2016 ◽  
Vol 88 (6) ◽  
pp. 3144-3148 ◽  
Author(s):  
Xue Zou ◽  
Meng Kang ◽  
Aiyue Li ◽  
Chengyin Shen ◽  
Yannan Chu
Keyword(s):  
Mass Spectrometry ◽  
Proton Transfer ◽  
Transfer Reaction ◽  
Online Monitoring ◽  
Proton Transfer Reaction ◽  
Reaction Mass

Application of proton-transfer-reaction-mass-spectrometry for Indoor Air Quality research

Indoor Air ◽  
2013 ◽  
Vol 24 (2) ◽  
pp. 178-189 ◽  
Author(s):  
T. Schripp ◽  
S. Etienne ◽  
C. Fauck ◽  
F. Fuhrmann ◽  
L. Märk ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Air Quality ◽  
Proton Transfer ◽  
Indoor Air Quality ◽  
Indoor Air ◽  
Transfer Reaction ◽  
Proton Transfer Reaction ◽  
Reaction Mass ◽  
Quality Research

Advanced online monitoring of cell culture off-gas using proton transfer reaction mass spectrometry

2014 ◽  
Vol 30 (2) ◽  
pp. 496-504 ◽  
Author(s):  
Timo Schmidberger ◽  
Rene Gutmann ◽  
Karl Bayer ◽  
Jennifer Kronthaler ◽  
Robert Huber
Keyword(s):  
Mass Spectrometry ◽  
Cell Culture ◽  
Proton Transfer ◽  
Transfer Reaction ◽  
Online Monitoring ◽  
Proton Transfer Reaction ◽  
Reaction Mass

scholarly journals Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes

2021 ◽  
Author(s):  
Benjamin Bayer ◽  
Andreas Maccani ◽  
Johanna Jahn ◽  
Mark Duerkop ◽  
Ewald Kapeller ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cell Culture ◽  
Process Control ◽  
Proton Transfer ◽  
Transfer Reaction ◽  
Online Monitoring ◽  
Proton Transfer Reaction ◽  
Reaction Mass ◽  
Hek 293 ◽  
Glucose Depletion

Abstract Objectives The applicability of proton-transfer-reaction mass spectrometry (PTR-MS) as a versatile online monitoring tool to increase consistency and robustness for recombinant adeno-associated virus (rAAV) producing HEK 293 bioprocesses was evaluated. We present a structured workflow to extract process relevant information from PTR-MS data. Results Reproducibility of volatile organic compound (VOC) measurements was demonstrated with spiking experiments and the process data sets used for applicability evaluation consisted of HEK 293 cell culture triplicates with and without transfection. The developed data workflow enabled the identification of six VOCs, of which two were used to develop a soft sensor providing better real-time estimates than the conventional capacitance sensor. Acetaldehyde, another VOC, provides online process information about glucose depletion that can directly be used for process control purposes. Conclusions The potential of PTR-MS for HEK 293 cell culture monitoring has been shown. VOC data derived information can be used to develop soft sensors and to directly set up new process control strategies.

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