Plasma levels of soluble fibrin in patients with malignancy-associated disseminated intravascular coagulation

1994 ◽  
Vol 5 (5) ◽  
pp. 725-730 ◽  
Author(s):  
K Nakagawa ◽  
H Tsuji ◽  
H Masuda ◽  
K Yamada ◽  
Y Yamada ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Plasma Levels ◽  
Soluble Fibrin ◽  
Intravascular Coagulation

scholarly journals Increased Soluble Fibrin in Plasma of Patients with Disseminated Intravascular Coagulation

2003 ◽  
Vol 9 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Hideo Wada ◽  
Tomohiro Sase ◽  
Takeshi Matsumoto ◽  
Fumihiko Kushiya ◽  
Miho Sakakura ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Plasma Levels ◽  
Operating Characteristic ◽  
Degradation Products ◽  
Characteristic Analysis ◽  
Soluble Fibrin ◽  
Intravascular Coagulation ◽  
Hemostatic Markers ◽  
Plasmin Inhibitor

Plasma levels of soluble fibrin (SF) were measured in 1184 patients with disseminated intravascular coagulation (DIC) according to Japanese Ministry of Health and Welfare (JMHW) criteria. The usefulness of SF for the diagnosis of DIC was compared with other hemostatic molecular markers. Most hemostatic markers were significantly increased in patients with DIC than in those without DIC. Plasma levels of fibrin and fibrinogen degradation products, thrombin-antihtrombin complex, plasmin-plasmin inhibitor complex, D-dimer, thrombomodulin, and SF levels were also significantly higher in those with pre-DIC than in those without DIC. In classification of overt DIC by International Society of Thrombosis and Haemostasis (ISTH) criteria, most hemostatic markers were significantly increased in patients with overt DIC than in those without overt DIC. Plasma levels of SF 'in patients with DIC were significantly higher than those in patients with pre-DIC, which were significantly higher than in those without DIC. Plasma levels of SF were also significantly higher in patients with overt DIC than in those with non-overt DIC. The correlation between plasma SF levels and DIC score according to JMHW criteria or ISTH criteria was good. Receiver operating characteristic analysis shows that SF was the best marker for the diagnosis of DIC or overt DIC. These findings suggest that plasma SF might be useful marker for the diagnosis of DIC or overt DIC.

Changes in Plasma Levels of Prothrombin Fragment F1+2 in Cases of Disseminated Intravascular Coagulation

1993 ◽  
Vol 89 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Hidesaku Asakura ◽  
Yoshimune Shiratori ◽  
Hiroshi Jokaji ◽  
Masanori Saito ◽  
Chika Uotani ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Plasma Levels ◽  
Prothrombin Fragment ◽  
Intravascular Coagulation

Plasma levels of soluble thrombomodulin increase in cases of disseminated intravascular coagulation with organ failure

1991 ◽  
Vol 38 (4) ◽  
pp. 281-287 ◽  
Author(s):  
Hidesaku Asakura ◽  
Hiroshi Jokaji ◽  
Masanori Saito ◽  
Chika Uotani ◽  
Ichiro Kumabashiri ◽  
...  
Keyword(s):  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Plasma Levels ◽  
Soluble Thrombomodulin ◽  
Intravascular Coagulation

EVIDENCE AGAINST DIC IN LIVER CIRRHOSIS

1987 ◽  
Author(s):  
G Fiori ◽  
G Mombelli ◽  
A Haeberli ◽  
P W Straub
Keyword(s):  
Liver Cirrhosis ◽  
Disseminated Intravascular Coagulation ◽  
Plasma Levels ◽  
Healthy Subjects ◽  
Major Determinant ◽  
Intravascular Coagulation ◽  
Fibrin Formation ◽  
Important Complication ◽  
Intravenous Heparin

To evaluate the hypothesis of disseminated intravascular coagulation (DIC) in liver cirrhosis (LC), we measured the plasma levels of fibrincpeptide A (FPA) and of fibrinogen-fibrin degradation fragment E (FgE) in 58 patients with LC, and compared the results with those measured in 32 healthy subjects as well as in 42 patients with ongoing fibrin formation and lysis related to acute thromboembolism (TE, n = 33) and overt DIC (n = 9).Results: Mean plasma FPA in LC was 2.4 ng/ml compared to 1.8 ng/ ml in normals (p < 0.05) and 12.2 ng/ml in patients with TE or DIC (p < 0.0001). Mean plasma FgE in LC was 108 ng/ml compared to 31.2 ng/ml in normals (p < 0.0001) and to 616 ng/ml in patients with TE or DIC (p < 0.0001). 15 patients with LC (26%) had hypo-fibrinogenemia (fibrinogen< 1.7 g/L). Among these patients, plasma FPA and FgE were 2.3 and 134 ng/ml, as compared to 22.1 and 1310 ng/ml in patients with hypofibrinogenemia related to DIC (p < 0.0001). Intravenous heparin (60 IU/kg) resulted in a prompt decrease of plasma FPA in 14 patients with TE or DIC from 11.8 to 4.3 ng/ml (p < 0.005), but did not significantly change the FPA level in 15 patients with LC as well as in the healthy subjects. Discussion: The present data indicate that thrombin mediated proteolysis of fibrinogen is only marginally increased in LC regardless of whether hypofibrinogenemia is present or not. The data are strongly against the hypothesis of DIC as a frequent and quantitatively important complication of LC and substantiate the conclusion that a “oonsunption coagulopathy” is not a major determinant of impaired hemostasis in liver cirrhosis.

Measurement of soluble fibrin monomer-fibrinogen complex in plasmas derived from patients with various underlying clinical situations

2003 ◽  
Vol 89 (05) ◽  
pp. 832-836 ◽  
Author(s):  
Yumiko Kazahaya ◽  
Yuichi Shintani ◽  
Kensuke Yamazumi ◽  
Yutaka Eguchi ◽  
Shin Koga ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Disseminated Intravascular Coagulation ◽  
Degradation Products ◽  
Research Society ◽  
Distinct Entity ◽  
Soluble Fibrin ◽  
Intravascular Coagulation ◽  
Fibrin Degradation Products ◽  
Fibrin Monomer ◽  
D Dimer

SummaryWe previously reported a monoclonal antibody named IF-43 that specifically recognizes thrombin-modified fibrinogen (desAA- and desAABB- fibrin monomer) bound with fibrinogen or other D1 domain-containing plasmic fragments such as fragments X, Y, and D1, but not intact fibrinogen or cross-linked fibrin degradation products (XDP). Here, we tentatively named such complexes, soluble fibrin monomer (FM) -fibrinogen complex.By utilizing IF-43, we have developed a kit to measure soluble FM-fibrinogen complex and compared the profiles with those of two established molecular markers for thrombo-embolic disorders: i.e. the thrombin-antithrombin complex (TAT) and the D-dimer in plasma of patients who underwent surgery without any thrombo-embolic complications. The result indicated that soluble FM-fibrinogen complex is a distinct entity from the two established molecular markers. We have also attempted to observe their profiles in patients with the disseminated intravascular coagulation syndrome (DIC). Although the profiles of soluble FM-fibrinogen complex in individual patients appeared to vary from one patient to the other, the plasma level of soluble FM-fibrinogen complex was found to be increased at the initial phase of disseminated intravascular coagulation syndrome. Thus, the soluble FM-fibrinogen complex may serve as an independent molecular marker for the detection of thrombin generation and the diagnosis of thrombosis. The soluble FM-fibrinogen complex may also serve as a risk factor for thrombosis, because it may precipitate as insoluble complexes beyond its threshold in plasma, or when it is modified by thrombin.Part of this paper was originally presented at the 17th International Fibrinogen Workshop of the International Fibrinogen Research Society (IFRS) held in Munich, Germany, September, 2002.

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