The development of the nociceptive responses in neurokinin-1 receptor knockout mice

Neuroreport ◽  
2000 ◽  
Vol 11 (3) ◽  
pp. 587-591 ◽  
Author(s):  
Tamara E. King ◽  
Mark J. S. Heath ◽  
Pierre Debs ◽  
Marion B. E. Davis ◽  
René Hen ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Neurokinin 1 Receptor ◽  
Nociceptive Responses ◽  
Neurokinin 1

Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice

2003 ◽  
Vol 980 (2) ◽  
pp. 213-220 ◽  
Author(s):  
Kristiana Kandere-Grzybowska ◽  
Daniela Gheorghe ◽  
Josef Priller ◽  
Pamela Esposito ◽  
Man Huang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Vascular Permeability ◽  
Knockout Mice ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition

2005 ◽  
Vol 83 (5) ◽  
pp. 386-396 ◽  
Author(s):  
Petra C. Arck ◽  
Bori Handjiski ◽  
Arne Kuhlmei ◽  
Eva M. J. Peters ◽  
Maike Knackstedt ◽  
...  
Keyword(s):  
Mast Cell ◽  
Growth Inhibition ◽  
Knockout Mice ◽  
Hair Growth ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice

2012 ◽  
Vol 105 (3) ◽  
pp. 669-675 ◽  
Author(s):  
Raúl Delgado-Morales ◽  
Eva del Río ◽  
Almudena Gómez-Román ◽  
Verónica Bisagno ◽  
Roser Nadal ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Restraint Stress ◽  
Behavioural Response ◽  
Chronic Restraint Stress ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

Nerve Injury-Induced Mechanical but Not Thermal Hyperalgesia Is Attenuated in Neurokinin-1 Receptor Knockout Mice

2000 ◽  
Vol 162 (2) ◽  
pp. 343-349 ◽  
Author(s):  
Heikki Mansikka ◽  
Rishi N. Sheth ◽  
Courtney DeVries ◽  
Hanna Lee ◽  
Richard Winchurch ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Knockout Mice ◽  
Thermal Hyperalgesia ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1 receptor gene knockout mice

2003 ◽  
Vol 18 (7) ◽  
pp. 1828-1836 ◽  
Author(s):  
Sara Morcuende ◽  
Christopher A. Gadd ◽  
Marco Peters ◽  
Andrew Moss ◽  
Elizabeth A. Harris ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Neurotrophic Factor ◽  
Gene Knockout ◽  
Receptor Gene ◽  
Brain Derived Neurotrophic Factor ◽  
Neurokinin 1 Receptor ◽  
Gene Knockout Mice ◽  
Neurokinin 1

scholarly journals Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor ‘knockout’ mice

2014 ◽  
Vol 127 ◽  
pp. 56-61 ◽  
Author(s):  
Katharine Pillidge ◽  
Ashley J. Porter ◽  
Temis Vasili ◽  
David J. Heal ◽  
S. Clare Stanford
Keyword(s):  
Knockout Mice ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

Sensory Processing in the Deep Spinal Dorsal Horn of Neurokinin-1 Receptor Knockout Mice

2001 ◽  
Vol 94 (6) ◽  
pp. 1105-1112 ◽  
Author(s):  
Han-Rong Weng ◽  
Heikki Mansikka ◽  
Ronald Winchurch ◽  
Srinivasa N. Raja ◽  
Patrick M. Dougherty
Keyword(s):  
Dorsal Horn ◽  
Knockout Mice ◽  
Mustard Oil ◽  
Wild Type ◽  
Nociceptive Neurons ◽  
Neurokinin 1 Receptor ◽  
Acute Responses ◽  
C Fiber ◽  
Neurokinin 1 ◽  
Electrical Stimuli

Background The neurokinin-1 receptor and its primary ligand, substance P, are widely recognized as contributing to the spinal processing of nociceptive stimuli, yet the specific function of the neurokinin-1 receptor remains unclear. Methods To better clarify these functions, the authors examined the neurophysiologic responses of L4-L5 neurons in the deep dorsal horn to acute mechanical, thermal, and electrical stimuli in knockout and wild-type mice. In addition, the capacity of knockout and wild-type mice to show wind-up to repeated C-fiber stimuli and to show sensitization after cutaneous mustard oil was assessed. Results A total of 68 nociceptive neurons (35 in knockout, 33 in wild type) in laminae III-V were studied. No differences in the acute responses of neurons in knockout and wild-type mice to graded mechanical, thermal, or electrical stimuli or in the acute responses to mustard oil were observed. However, wind-up to repeated electrical stimulation at C-fiber intensity was significantly attenuated in the knockout mice compared with wild type controls. In addition, mustard oil-induced mechanical hypersensitivity was significantly reduced in the knockout mice. Conclusions These results indicate that neurokinin-1 receptors do not play a significant role in the responses of nociceptive neurons in the deep spinal dorsal horn to acute noxious mechanical, thermal, electrical, or chemical stimuli. On the other hand, neurokinin-1 receptors are critical for the central hyperexcitability that is observed in these neurons with repeated C-fiber inputs and to the central sensitization induced by topical mustard oil application.

Sign in / Sign up

Export Citation Format

Share Document