Foreign Body Giant Cell Reaction Associated with Epidermoid Tumor

1995 ◽  
Vol 19 (4) ◽  
pp. 628-630 ◽  
Author(s):  
Catherine C. Moran ◽  
Saeed T. Vakili ◽  
Karen S. Caldemeyer ◽  
Richard R. Smith
Keyword(s):  
Foreign Body ◽  
Giant Cell ◽  
Foreign Body Giant Cell ◽  
Cell Reaction ◽  
Epidermoid Tumor

scholarly journals Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy

2019 ◽  
Vol 72 (8) ◽  
pp. 550-553 ◽  
Author(s):  
Martin J Magers ◽  
Hristos Z Kaimakliotis ◽  
Marcelo P Barboza ◽  
Elhaam Bandali ◽  
Nabil Adra ◽  
...  
Keyword(s):  
Foreign Body ◽  
Neoadjuvant Chemotherapy ◽  
Urothelial Carcinoma ◽  
Giant Cell ◽  
Chronic Inflammation ◽  
Morphological Features ◽  
Foreign Body Giant Cell ◽  
Cell Reaction ◽  
Variant Histology

AimsTo describe a large tertiary care academic centre’s experience with patients who achieve a complete pathological response (ie, ypT0N0) following neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) with emphasis on morphological features present in the RC and clinical outcome.Methods41 patients with ypT0N0 disease following transurethral resection of bladder tumour (TURBT), NAC and RC with available clinical follow-up information were analysed. Slides from all RCs were reviewed to confirm pathological stage and assess for morphological parameters (eg, foreign body giant cell reaction, dystrophic calcification, scar and fat necrosis).ResultsWith median follow-up of 32.8 months, the recurrence-free survival at 1 and 5 years was 97.4% and 93.5%, while the overall survival at 3 and 5 years was 94.2% and 88.6%, respectively. No patients died of urothelial carcinoma. Stage assigned at TURBT was 1 pTa (2%), 1 pT1 (2%), 38 pT2 (93%) and 1 pT3a (2%). 17 TURBTs demonstrated variant histology, with the majority of these being squamous (65%). The most common morphological features present at RC were scar (100%), foreign body giant cell reaction (80%), chronic inflammation within lamina propria (68%) and dystrophic calcifications (39%). Other morphological features were less common or absent.ConclusionypT0N0 disease at RC portends an excellent prognosis, regardless of stage or variant histology in the TURBT; scar, foreign body giant cell reaction, chronic inflammation and dystrophic calcifications are often present.

Foreign-Body Giant-Cell Reaction at the Donor Site After Autologous Osteochondral Transplant for Cartilaginous Lesion

2009 ◽  
Vol 91 (4) ◽  
pp. 945-949 ◽  
Author(s):  
Umile Giuseppe Longo ◽  
Francesco Franceschi ◽  
Laura Ruzzini ◽  
Carla Rabitti ◽  
Nicola Maffulli ◽  
...  
Keyword(s):  
Foreign Body ◽  
Giant Cell ◽  
Donor Site ◽  
Foreign Body Giant Cell ◽  
Cell Reaction ◽  
Cartilaginous Lesion

Foreign-Body Giant Cell Reaction to Liquid Silicone

1986 ◽  
Vol 101 (6) ◽  
pp. 680-683 ◽  
Author(s):  
Vernon C. Parmley ◽  
Y. Robert Barishak ◽  
Edward L. Howes ◽  
J. Brooks Crawford
Keyword(s):  
Foreign Body ◽  
Giant Cell ◽  
Foreign Body Giant Cell ◽  
Cell Reaction ◽  
Liquid Silicone

scholarly journals Efferent Loop Syndrome in a Post-pancreatoduodenectomy Patient Due to Exuberant Foreign Body Giant Cell Reaction Mimicking Cancer: A Case Report

Cureus ◽  
2019 ◽  
Author(s):  
Humaid Ahmad ◽  
Omema Saleem ◽  
Muhammad Zeeshan Raza ◽  
Jahanzaib Haider ◽  
Shams Nadeem Alam
Keyword(s):  
Case Report ◽  
Foreign Body ◽  
Giant Cell ◽  
Foreign Body Giant Cell ◽  
Cell Reaction

Bilaterally symmetrical epidermal inclusion cysts with foreign-body giant-cell reaction

1998 ◽  
Vol 88 (8) ◽  
pp. 410-413 ◽  
Author(s):  
J Sheff ◽  
P Bregman ◽  
T Curran
Keyword(s):  
Foreign Body ◽  
Giant Cell ◽  
Epidermal Cells ◽  
Foreign Body Giant Cell ◽  
Review Of The Literature ◽  
Cell Reaction ◽  
Dermal Tissue

Epidermal inclusion cysts often occur as a result of traumatic implantation of epidermal cells into dermal tissue. The epidermal cells within the dermis can continue to grow and lead to the production of a lipid- and keratin-filled cyst, which can erode into bone and adjacent tissues. The authors present a case of bilaterally symmetrical epidermal inclusion cysts that occurred separately over a 10-year period. A brief review of the literature is also presented.

scholarly journals Histological Analysis of Early Osteolysis in Total Ankle Arthroplasty

2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0000 ◽  
Author(s):  
Oliver Schipper ◽  
Steven Haddad
Keyword(s):  
Foreign Body ◽  
Giant Cell ◽  
Histological Analysis ◽  
Polyethylene Wear ◽  
Giant Cells ◽  
Foreign Body Giant Cell ◽  
Control Group ◽  
Wear Particles ◽  
Cell Reaction ◽  
Ankle Arthroplasty

Category: Ankle Arthritis Introduction/Purpose: The purpose of this study was to perform a histological comparative analysis of tibiotalar joint samples taken from areas of osteolysis adjacent to total ankle arthroplasties vs control synovial specimens to determine the reaction to and presence of polyethylene (PE) particles. Methods: A total of 57 pathology samples were identified in the osteolysis group, while 11 were identified in the control group. For each sample, hematoxylin and eosin, Oil Red O (ORO), and macrophage marker CD163-stained slides were created. Polarized light and ORO stain were used to identify PE particles. The presence of metal particles and giant cell reaction to PE particles were also scored. Results: Macrophages, PE particles, metallosis, and foreign body giant cell reaction scores were significantly higher in the osteolysis group compared with the control group. In the osteolysis group, ORO staining was positive in 93% (53/57), birefringent material was present in 96.5% (55/57), and macrophage infiltrates were present in 96.5% (55/57). Foreign body giant cell reaction with giant cells surrounding PE particles was present in 49.1% (28/57) of osteolytic specimens. The presence of foreign body giant cell reaction was associated with significantly higher macrophage, ORO, and polarizable material scores. The average time to surgery for osteolysis from the index ankle replacement was 6.0 (range, 0-15) years for the 57 patients in the osteolysis group. Conclusion: This study is the largest ankle arthroplasty histological analysis to show that areas of osteolysis consist of abundant polyethylene wear particles, present both intracellularly and extracellularly. Furthermore, these areas were associated with a CD163+ macrophage infiltrate and frequently a foreign body reaction with giant cells engulfing PE particles. It is likely that implant wear particles play a significant role in osteolysis based on the histopathology.

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