Correction for Partial Volume Effects in Regional Blood Flow Measurements Adjacent to Hematomas in Humans with Intracerebral Hemorrhage: Implementation and Validation

1999 ◽  
Vol 23 (2) ◽  
pp. 248-256 ◽  
Author(s):  
Tom O. Videen ◽  
Jane E. Dunford-Shore ◽  
Michael N. Diringer ◽  
William J. Powers
Keyword(s):  
Blood Flow ◽  
Intracerebral Hemorrhage ◽  
Regional Blood Flow ◽  
Flow Measurements ◽  
Partial Volume ◽  
Partial Volume Effects ◽  
Blood Flow Measurements ◽  
Volume Effects

Hybrid blood flow probe for simultaneous H2 clearance and laser-Doppler velocimetry

1987 ◽  
Vol 253 (4) ◽  
pp. G573-G581 ◽  
Author(s):  
G. R. DiResta ◽  
J. W. Kiel ◽  
G. L. Riedel ◽  
P. Kaplan ◽  
A. P. Shepherd
Keyword(s):  
Blood Flow ◽  
Laser Doppler Velocimetry ◽  
Regional Blood Flow ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Flow Probe ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
Light Guides ◽  
The Relationship

To perform two independent regional blood flow measurements in tissue volumes of similar dimensions, we designed a hybrid blood flow probe capable of measuring regional perfusion by both laser-Doppler velocimetry (LDV) and H2 clearance. The probe consisted of two fiber-optic light guides to conduct light between the surface of tissue of interest and a laser-Doppler blood flowmeter. Also contained within the probe were a platinum 25-microns H2-sensing electrode and a 125-microns H2-generating electrode. The probe can thus be used to measure local perfusion with H2 clearance. The H2 can either be inhaled or can be generated electrochemically at the locus of interest. Evaluation of the probe in the canine gastric mucosa indicated 1) that the relationship between mucosal flow measurements made simultaneously with H2 clearance and LDV was highly significant and linear and 2) that H2 clearance could potentially be used to calibrate the laser-Doppler blood flowmeter in absolute units. The methods of constructing the flow probes are discussed in detail.

A model for regional blood flow measurements during cardiopulmonary resuscitation in a swine model

Resuscitation ◽  
1988 ◽  
Vol 16 (2) ◽  
pp. 107-118 ◽  
Author(s):  
R.B. Taylor ◽  
C.G. Brown ◽  
T. Bridges ◽  
H.A. Wermam ◽  
J. Ashton ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiopulmonary Resuscitation ◽  
Regional Blood Flow ◽  
Swine Model ◽  
Flow Measurements ◽  
Blood Flow Measurements

scholarly journals Dramatic Increase in Cerebral Blood Flow following Soman Intoxication If Signs of Symptoms Can Be Seen

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Ann Göransson Nyberg ◽  
Gudrun E. Cassel
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Blood Flow ◽  
Acetylcholinesterase Activity ◽  
Organophosphate Poisoning ◽  
Flow Measurements ◽  
Anaesthetized Rats ◽  
Compound Exposure ◽  
Treat All ◽  
Blood Flow Measurements

Organophosphate poisoning is associated with adverse effects on the central nervous system such as seizure/convulsive activity and long term changes in neuronal networks. This study report an investigation designed to assess the consequences of Soman, a highly toxic organophosphorus compound, exposure on regional blood flow in the rat brain and peripheral organs. We performed repeated blood flow measurements in the same animal, using the microspheres technique, to characterize changes in regional blood flow at different times after Soman intoxication. In addition, the cardiopulmonary effects of Soman were followed during the intoxication. Administration of Soman (1 LD50; 90 µg/kg, s.c.) to anaesthetized rats produced a decrease in blood acetylcholinesterase activity in all animals tested. Although, only six out of ten rats showed signs of poisoning like a decrease in respiratory rate, the results show that only animals with significant signs of poisoning demonstrated an increase in cerebral blood flow. We conclude that it is of great importance to treat all data individually. An overall mean can easily be misinterpreted and conceal important effects. We also conclude that the increase in cerebral blood flow has an important role in the effect on respiration and that this effect is independent of the blood acetylcholinesterase activity.

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