Melperone, an atypical antipsychotic drug, in the treatment of schizophrenia: dose-response analysis on effectiveness and tolerability, and efficacy for treatment-resistant schizophrenia and cognitive function

2004 ◽  
Vol 19 (3) ◽  
pp. 184 ◽  
Author(s):  
Tomiki Sumiyoshi ◽  
Herbert Y. Meltzer ◽  
Karu Jayathilake
Keyword(s):  
Cognitive Function ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drug ◽  
Dose Response ◽  
Response Analysis ◽  
Treatment Resistant ◽  
Atypical Antipsychotic Drug

Are Atypical Antipsychotic Drugs also Atypical Antidepressants?

2001 ◽  
Vol 35 (5) ◽  
pp. 631-638 ◽  
Author(s):  
Gordon Parker ◽  
Gordon Parker ◽  
Gin Malhi
Keyword(s):  
Atypical Antipsychotic ◽  
Antipsychotic Drug ◽  
Antipsychotic Drugs ◽  
Case Series ◽  
Antidepressant Activity ◽  
Typical Antipsychotic ◽  
Treatment Resistant ◽  
Melancholic Depression ◽  
Atypical Antipsychotic Drug ◽  
Atypical Antipsychotic Drugs

Objective: To report a case series and review the psychopharmacology of the neuroleptic drugs to suggest that the atypical antipsychotic drugs may have an antidepressant action, at least for those patients with the melancholic subtype. Method: We note the literature suggesting that the older (or typical) antipsychotic drugs were established as having antidepressant activity, describe an open study of some two dozen patients with a treatment-resistant melancholic depression, describe rapid resolution of depression and augmentation benefits associated with commencing an atypical antipsychotic drug in a percentage of subjects, and then review relevant psychopharmacological studies to consider whether there is a rationale for use of antipsychotic drugs to treat depression. Results: Of some two dozen patients treated with an atypical antipsychotic drug, almost immediate improvement was noted in four patients, and evidence of augmentation benefit obtained in another three patients. Conclusions: Impressions from this case series are encouraging. However, as open clinical observational studies are problematic, controlled studies are required to establish whether the atypical antipsychotic drugs have a role in the management of certain expressions of depression, and, in particular, treatment-resistant melancholic depression.

ICI 204,636: A new and novel atypical antipsychotic drug

1990 ◽  
Vol 3 (1) ◽  
pp. 46
Author(s):  
J.B. Malick ◽  
B.M. Migler ◽  
A.I. Salama ◽  
J.M. Goldstein ◽  
C.F. Saller ◽  
...  
Keyword(s):  
Atypical Antipsychotic ◽  
Antipsychotic Drug ◽  
Atypical Antipsychotic Drug ◽  
Ici 204,636

The atypical antipsychotic drug clozapine enhances chronic PCP-induced regulation of prefrontal cortex 5-HT2A receptors

2004 ◽  
Vol 47 (4) ◽  
pp. 527-537 ◽  
Author(s):  
Lucinda J. Steward ◽  
Matthew D. Kennedy ◽  
Brian J. Morris ◽  
Judith A. Pratt
Keyword(s):  
Prefrontal Cortex ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drug ◽  
Atypical Antipsychotic Drug

Psychopharmacology of olanzapine

1999 ◽  
Vol 174 (S38) ◽  
pp. 52-58 ◽  
Author(s):  
C. M. E. Stephenson ◽  
L. S. Pilowsky
Keyword(s):  
Side Effects ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drug ◽  
Therapeutic Efficacy ◽  
Atypical Antipsychotics ◽  
Extrapyramidal Side Effects ◽  
Atypical Antipsychotic Drug ◽  
Blood Monitoring

The development of atypical antipsychotics has revolutionised the treatment of schizophrenia, as well as providing new insights into its cause. The archetypal atypical antipsychotic is clozapine, which has therapeutic advantages over traditional antipsychotics, as well as a low potential for producing extrapyramidal side-effects (EPS) (Kane et al, 1988). However, clozapine causes agranulocytosis in 1% of patients, and there has consequently been a search for novel atypical antipsychotics, as efficacious as clozapine, but without the need for intensive blood monitoring. There has been much discussion of the definition and characteristics of an atypical antipsychotic drug, and an operational understanding seems to have been agreed upon, that atypical drugs have therapeutic efficacy in treating schizophrenia, without producing EPS (Deutch et al, 1991; Kerwin, 1994).

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