scholarly journals Lithium or an atypical antipsychotic drug in the management of treatment-resistant depression: a systematic review and economic evaluation

2013 ◽  
Vol 17 (54) ◽  
Author(s):  
SJ Edwards ◽  
V Hamilton ◽  
L Nherera ◽  
N Trevor
Keyword(s):  
Systematic Review ◽  
Economic Evaluation ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drug ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Atypical Antipsychotic Drug ◽  
Resistant Depression

scholarly journals Atypical Antipsychotic Augmentation for Treatment-Resistant Depression: A Systematic Review and Network Meta-Analysis

2015 ◽  
Vol 18 (11) ◽  
pp. pyv060 ◽  
Author(s):  
Xinyu Zhou ◽  
Gabor I Keitner ◽  
Bin Qin ◽  
Arun V Ravindran ◽  
Michael Bauer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Atypical Antipsychotic ◽  
Meta Analysis ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

scholarly journals Augmentation therapies for treatment-resistant depression: systematic review and meta-analysis – CORRIGENDUM

2018 ◽  
Vol 214 (5) ◽  
pp. 308-308
Author(s):  
Rebecca Strawbridge ◽  
Ben Carter ◽  
Lindsey Marwood ◽  
Borwin Bandelow ◽  
Dimosthenis Tsapekos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

scholarly journals Deep Brain Stimulation for Treatment-resistant Depression: Systematic Review of Clinical Outcomes

2014 ◽  
Vol 11 (3) ◽  
pp. 475-484 ◽  
Author(s):  
Takashi Morishita ◽  
Sarah M. Fayad ◽  
Masa-aki Higuchi ◽  
Kelsey A. Nestor ◽  
Kelly D. Foote
Keyword(s):  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Clinical Outcomes ◽  
Brain Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression ◽  
Deep Brain

scholarly journals Placebo response in treatment resistant depression: a systematic review and meta-analysis of multiple treatment modalities

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S261-S262
Author(s):  
Brett D M Jones ◽  
Cory R. Weissman ◽  
Jewel Karbi ◽  
Tya Vine ◽  
Louise S. Mulsant ◽  
...  
Keyword(s):  
Systematic Review ◽  
Brain Stimulation ◽  
Placebo Effect ◽  
Meta Analysis ◽  
Specific Treatment ◽  
Placebo Response ◽  
Treatment Modalities ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

AimsThe placebo response in depression clinical trials is a major contributing factor for failure to establish the efficacy of novel and repurposed treatments. However, it is not clear as to what the placebo response in treatment-resistant depression (TRD) patients is or whether it differs across treatment modalities. Our objective was to conduct a systematic review and meta-analysis of the magnitude of the placebo response in TRD patients across different treatment modalities and its possible moderators.MethodSearches were conducted on MEDLINE and PsychInfo from inception to January 24, 2020. Only studies that recruited TRD patients and randomization to a placebo (or sham) arm in a pharmacotherapy, brain stimulation, or psychotherapy study were included (PROSPERO 2020 CRD42020190465). The primary outcome was the Hedges’ g for the reported depression scale using a random-effects model. Secondary outcomes included moderators assessed via meta-regression and response and remission rate. Heterogeneity was evaluated using the Egger's Test and a funnel plot. Cochrane Risk of Bias Tool was used to estimate risks.Result46 studies met our inclusion criteria involving a total of 3083 participants (mean (SD) age: 45.7 (6.2); female: 52.4%). The pooled placebo effect for all modalities was large (N = 3083, g = 1.08 ,95% CI [0.95-1.20)I 2 = 0.1). The placebo effect in studies of specific treatment modalities did not significantly differ: oral medications g = 1.14 (95%CI:0.99-1.29); parenteral medications g = 1.32 (95%CI:0.59-2.04); ayahuasca g = 0.47 (95%CI:-0.28-1.17); rTMS g = 0.93 (95%CI:0.63-1.23); tDCS g = 1.32 (95%CI:0.52-2.11); invasive brain stimulation g = 1.06 (95%CI:0.64-1.47). There were no psychotherapy trials that met our eligibility criteria. Similarly, response and remission rates were comparable across modalities. Heterogeneity was large. Two variables predicted a lager placebo effect: open-label prospective design (B:0.32, 95%CI: 0.05-0.58; p:0.02) and sponsoring by a pharmaceutical or medical device company (B:0.39, 95%CI:0.13-0.65, p:0.004)). No risk of publication bias was found.ConclusionThe overall placebo effect in TRD studies was large (g = 1.08) and did not differ among treatment modalities. A better understanding of the placebo response in TRD will require: standardizing the definition of TRD, head-to-head comparisons of treatment modalities, an assessment of patient expectations and experiences, and standardized reporting of outcomes.

Relative effectiveness of augmentation treatments for treatment-resistant depression: a systematic review and network meta-analysis

2020 ◽  
Vol 32 (5-6) ◽  
pp. 477-490 ◽  
Author(s):  
Ben Carter ◽  
Rebecca Strawbridge ◽  
Muhammad Ishrat Husain ◽  
Brett D. M. Jones ◽  
Roxanna Short ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Relative Effectiveness ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

scholarly journals Is ketamine an appropriate alternative to ECT for patients with treatment resistant depression? A systematic review

2021 ◽  
Vol 281 ◽  
pp. 82-89
Author(s):  
Jolien K.E. Veraart ◽  
Sanne Y. Smith-Apeldoorn ◽  
Harm-Pieter Spaans ◽  
Jeanine Kamphuis ◽  
Robert A. Schoevers
Keyword(s):  
Systematic Review ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

scholarly journals Augmentation therapies for treatment-resistant depression: a systematic review and meta-analysis

2019 ◽  
Vol 254 ◽  
pp. 153
Author(s):  
Dr Rebecca Strawbridge ◽  
Dr Ben Carter ◽  
Dr Lindsey Marwood ◽  
Professor Borwin Bandelow ◽  
Dimosthenis Tsapekos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression
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