P0947 ZINC DEFICIENCY AND TRANSITORY ACRODERMATITIS ENTEROPATHICA IN PRETERM BREAST-FED INFANT

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S418
Author(s):  
J. Carnicer ◽  
G. Arca ◽  
C. Goyanes ◽  
I. Badell ◽  
E. Baselga ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Acrodermatitis Enteropathica ◽  
Breast Fed

scholarly journals Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant

2021 ◽  
Vol 13 (3) ◽  
pp. 444-449
Author(s):  
Giovanna D’Amico ◽  
Corinne De Laet ◽  
Guillaume Smits ◽  
Deborah Salik ◽  
Guillaume Deprez ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Premature Infants ◽  
Zinc Supplementation ◽  
Good Prognosis ◽  
Acrodermatitis Enteropathica ◽  
Born Infant ◽  
Laboratory Investigations ◽  
Zinc Levels ◽  
Breast Fed ◽  
Low Serum

We present a case of a transient acquired zinc deficiency in a breast-fed, 4-month-old-male prematurely born infant, with acrodermatitis enteropathica-like symptoms such as crusted, eroded, erythemato-squamous eruption in periorificial and acral patterns. The laboratory investigations showed low zinc levels in the infant’s and the mother’s serum and in the mother’s milk; genetic analysis did not show any mutation in the SLC39A4 gene, involved in acrodermatitis enteropathica. Acquired zinc deficiency is often found in premature infants because of their increased requirement, the low serum and milk zinc levels in breastfeeding women being also an important risk factor, as in this case. A prompt zinc supplementation is essential for the good prognosis of the disease.

Zinc and Acrodermatitis Enteropathica

1980 ◽  
Vol 2 (3) ◽  
pp. 88-94
Keyword(s):  
Zinc Deficiency ◽  
Autosomal Recessive ◽  
Acid Metabolism ◽  
Autosomal Recessive Disease ◽  
Dna Polymerases ◽  
Clinical Manifestations ◽  
Acrodermatitis Enteropathica ◽  
Nucleic Acid Metabolism ◽  
Zinc Metalloenzymes ◽  
Rna And Dna

Mammalian zinc metalloenzymes include alkaline phosphatase. Zinc plays a crucial role in nucleic acid metabolism. RNA and DNA polymerases and thymidine kinase are zinc-dependent enzymes. Zinc deficiency in North America is most clearly seen in the disease acrodermatitis enteropathica. This is an autosomal recessive disease due to a zinc metabolic error—not well defined—which leads to zinc deficiency. Clinical manifestations include a rash around orifices, alopecia, and diarrhea. The laboratory can demonstrate hypozincemia and hypozincuria. Clinical and biochemical remission occurs with oral zinc administration.(R.H.R.)

Zinc-deficiency dermatitis in breast-fed infants

2006 ◽  
Vol 166 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Antonia Kienast ◽  
Bernhard Roth ◽  
Christiane Bossier ◽  
Christina Hojabri ◽  
Peter H. Hoeger
Keyword(s):  
Zinc Deficiency ◽  
Breast Fed

Zinc Deficiency, Acrodermatitis Enteropathica, Optic Atrophy, Subacute Myelo-optic Neuropathy, and 5,7-Dihalo-8-quinolinols

PEDIATRICS ◽  
1980 ◽  
Vol 65 (3) ◽  
pp. 610-613
Author(s):  
Frank M. Sturtevant
Keyword(s):  
Zinc Deficiency ◽  
Optic Neuropathy ◽  
Optic Atrophy ◽  
Visual Function ◽  
Drug Toxicity ◽  
Acrodermatitis Enteropathica ◽  
Alternate Hypothesis

Acrodermatitis enteropathica, a heritable disease of zinc deficiency, was formerly amenable to treatment only with dihaloquinolinol drugs. A few cases of optic atrophy were reported in surviving patients and were proposed as examples of ocular drug toxicity, principally because of the association between iodochlorhy-droxyquin and subacute myelo-optic neuropathy (SMON) in Japan. An alternate hypothesis is now offered: that the optic atrophy was secondary to the zinc deficiency, which is consistent with diverse evidence cited from the literature. Therefore, it would seem worthwhile to investigate zinc in cases of disk pallor described as idiopathic or drug associated, and to investigate visual function in cases of severe malnourishment.

scholarly journals Acrodermatitis enteropathica: a hereditary form of zinc deficiency

QJM ◽  
2020 ◽  
Author(s):  
S Higuchi ◽  
T Yorifuji ◽  
M Nishida ◽  
K Fukai ◽  
H Nakano
Keyword(s):  
Zinc Deficiency ◽  
Acrodermatitis Enteropathica
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