Arterial Reactivity, Blood Pressure, and Plasma Levels of Atrial Natriuretic Peptides in Normotensive and Hypertensive Rats

1. Plasma levels of atrial natriuretic peptide (ANP) were measured by radioimmunoassay in eight normal healthy volunteers before and during mineralocorticoid escape. 2. Mean plasma ANP on a fixed sodium intake before fludrocortisone was 6.5± sem 1.1 pg/ml. Within 24 h of fludrocortisone administration there was a significant increase in plasma ANP which continued to increase daily reaching a plateau by day 4 (14.9 ± 2.4 pg/ml) to day 7 (15.1 ± 2.6 pg/ml). 3. The rise in plasma ANP was closely related to the amount of sodium retained during the fludrocortisone treatment and the sodium ‘escape’ occurred by days 4 to 7. 4. These results support the concept that ANP could play an important hormonal role in overcoming the sodium-retaining effects of mineralocorticoids in man.

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Raised plasma levels of atrial natriuretic peptides in Addison’s disease

Journal of Endocrinological Investigation ◽

10.1007/bf03349963 ◽

1989 ◽

Vol 12 (3) ◽

pp. 205-207 ◽

Cited By ~ 5

Author(s):

F. P. Cappuccio ◽

N. D. Markandu ◽

M. G. Buckley ◽

A. L. Sugden ◽

G. A. Sagnella ◽

...

Keyword(s):

Natriuretic Peptides ◽

Plasma Levels ◽

Addison’S Disease ◽

Addison's Disease ◽

Atrial Natriuretic Peptides ◽

Atrial Natriuretic

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Circulating Atrial Natriuretic Peptides in Spontaneously Hypertensive Rats

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-198700105-00007 ◽

1987 ◽

Vol 10 ◽

pp. S28-S33

Author(s):

Markus Haass ◽

Nadav Zamir ◽

Zofia Zukowska-Grojec

Keyword(s):

Natriuretic Peptides ◽

Spontaneously Hypertensive Rats ◽

Atrial Natriuretic Peptides ◽

Hypertensive Rats ◽

Spontaneously Hypertensive ◽

Atrial Natriuretic

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Temporal (Circadian) and Functional Relationship Between Atrial Natriuretic Peptides and Blood Pressure

Chronobiology International ◽

10.3109/07420529509064506 ◽

1995 ◽

Vol 12 (2) ◽

pp. 106-120 ◽

Cited By ~ 42

Author(s):

Robert B. Sothern ◽

David L. Vesely ◽

Eugene L. Kanabrocki ◽

Ramon C. Hermida ◽

Fraser W. Bremner ◽

...

Keyword(s):

Blood Pressure ◽

Natriuretic Peptides ◽

Functional Relationship ◽

Atrial Natriuretic Peptides ◽

Atrial Natriuretic

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Effects of Moxibustion on Blood Pressure and Renal Function in Spontaneously Hypertensive Rats

The American Journal of Chinese Medicine ◽

10.1142/s0192415x97000056 ◽

1997 ◽

Vol 25 (01) ◽

pp. 21-26 ◽

Cited By ~ 11

Author(s):

Ho Sub Lee ◽

Yun Cho Yu ◽

Seong Tae Kim ◽

Kyung Sik Kim

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Atrial Natriuretic Peptide ◽

Systolic Blood Pressure ◽

Natriuretic Peptide ◽

Plasma Levels ◽

Spontaneously Hypertensive Rats ◽

Hypertensive Rats ◽

Spontaneously Hypertensive ◽

Atrial Natriuretic

The aim of this study was to investigate the effects of moxibustion at the meridian points BL-15 (Xin-shu) and BL-27 (Xiao-chang-shu) on renal function, systolic blood pressure, plasma levels of renin activity, aldosterone and atrial natriuretic peptide in spontaneously hypertensive rats. The results showed that urine volume increased significantly after moxibustion at the meridian points BL-15, but decreased at BL-27. Urinary excretion of Na + decreased after moxibustion at the meridian points BL-15 and BL-27. Systolic blood pressure decreased after moxibustion at the meridian point BL-15. No effect was observed at BL-27. Plasma levels of aldosterone and renin activity increased significantly, but the levels of atrial natriuretic peptide decreased significantly after moxibustion at BL-15. Plasma levels of aldosterone and atrial natriuretic peptide increased significantly after moxibustion at the meridian points BL-27. These results suggest that the meridian points BL-15 and BL-27 are related to the regulation of renal function and the secretion of hormone with body fluid metabolism.

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