Therapeutic, But Not Low-Dose, Angiotensin-Converting Enzyme Inhibition Causes Regression of Cardiovascular Changes in Spontaneously Hypertensive Rats

1996 ◽  
Vol 27 (3) ◽  
pp. 327-334 ◽  
Author(s):  
Håkan Wåhlander ◽  
Morgan Sohtell ◽  
Anna Wickman ◽  
Annika Nilsson ◽  
Peter Friberg
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibition ◽  
Spontaneously Hypertensive Rats ◽  
Low Dose ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Cardiovascular Changes ◽  
Converting Enzyme Inhibition

scholarly journals Acute Sympathetic Denervation Does Not Eliminate the Effect of Angiotensin Converting Enzyme Inhibition on CBF Autoregulation in Spontaneously Hypertensive Rats

1990 ◽  
Vol 10 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Gunhild Waldemar
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibition ◽  
Spontaneously Hypertensive Rats ◽  
Sympathetic Nerves ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Control Group ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Converting Enzyme Inhibition

The effect of angiotensin converting enzyme inhibition with captopril (10 mg/kg i.v.) on CBF autoregulation was studied in 16 spontaneously hypertensive rats (8 control and 8 treated with captopril) subjected to acute cervical sympathectomy. CBF was measured repetitively by the intra-arterial 133Xe injection method, during the manipulation of MABP by norepinephrine or hemorrhagic hypotension. Prior to the administration of drugs, baseline MABP was 112 ± 10 mm Hg in the control group and 119 ± 11 mm Hg in the captopril group. Baseline CBF was 99 ± 19 ml/100 g/min, with no difference in the two groups. In agreement with previous findings in rats with intact sympathetic nerves, the lower limit of CBF autoregulation was reduced from the MABP interval of 70–89 to 50–69 mm Hg by captopril.

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