Interleukin-10 Stimulation of Endogenous Nitric Oxide Release from Human Saphenous Veins Diminishes Immunocyte Adherence

1997 ◽  
Vol 30 (1) ◽  
pp. 90-95 ◽  
Author(s):  
George B. Stefano ◽  
V. Brix Christensen ◽  
Else Tonnesen ◽  
Yu Liu ◽  
Thomas K. Hughes ◽  
...  
2004 ◽  
Vol 114 (9) ◽  
pp. 1642-1647 ◽  
Author(s):  
J??rgen Alberty ◽  
Christian August ◽  
Wolfgang Stoll ◽  
Claudia Rudack

Urology ◽  
2009 ◽  
Vol 74 (1) ◽  
pp. 216-221 ◽  
Author(s):  
Haroldo A. Toque ◽  
Fernanda B.M. Priviero ◽  
Cleber E. Teixeira ◽  
Mário A. Claudino ◽  
Juliana S. Baracat ◽  
...  

1996 ◽  
Vol 117 (6) ◽  
pp. 1270-1276 ◽  
Author(s):  
Michela Figini ◽  
Costanza Emanueli ◽  
Claude Bertrand ◽  
Panthea Javdan ◽  
Pierangelo Geppetti

Hypertension ◽  
2000 ◽  
Vol 35 (1) ◽  
pp. 324-328 ◽  
Author(s):  
Craig J. Hanke ◽  
Timothy O’Brien ◽  
Kirkwood A. Pritchard ◽  
William B. Campbell

1991 ◽  
Vol 17 (Supplement 3) ◽  
pp. S238-S242 ◽  
Author(s):  
Guy E. Boeckxstaens ◽  
Hidde Bult ◽  
Paul A. Pelckmans ◽  
Francois H. Jordaens ◽  
Joris G. De Man ◽  
...  

1995 ◽  
Vol 268 (6) ◽  
pp. H2246-H2251
Author(s):  
R. Mizuno ◽  
T. Ohhashi

5-Hydroxytryptamine (5-HT, 0.01-100 microM) and 5-carboxamidotryptamine (5-CT, 0.001-10 microM) produced dose-related relaxations in strips cut from monkey popliteal lymph nodes precontracted with a perfusion of Krebs bicarbonate solution containing 80 mM KCl. These 5-HT agonists caused no significant effect on the basal tone of the lymph node strips. The 5-HT-induced relaxation is competitively antagonized by pretreatment with a selective 5-HT1-like receptor antagonist, methiothepin (0.01-0.1 microM). Schild plot analysis showed that the pA2 value and slope of methiothepin against 5-HT were 8.80 +/- 0.11 and 0.99 +/- 0.07 (n = 6), respectively. Pretreatment with methysergide (0.01-0.1 microM) significantly attenuated the 5-HT-induced relaxation of the strips. On the other hand, treatment with ketanserin (0.01-0.1 microM) and ICS-205-930 (0.01-0.1 microM) caused no significant effect on the 5-HT-or the 5-CT-induced relaxation. The 5-HT-induced relaxation was significantly reduced by 10 microM NG-monomethyl-L-arginine, which was reversed by 1 mM L-arginine. The relaxation in the lymph node strips was also significantly reduced by treatment with 10 microM methylene blue but not with 30 microM aspirin. These results suggest that 5-HT1-like receptors exist in the monkey popliteal lymph nodes. Stimulation of these receptors produces an endogenous nitric oxide (NO)-dependent relaxation in lymph node smooth muscle through an activation of cytosolic guanylate cyclase in the cells.


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