Effects of Olprinone, a Phosphodiesterase 3 Inhibitor, on Regional Cerebral Blood Flow of Cerebral Cortex in Stroke Patients

TIA is usually caused by embolism from a carotid stenosis. The stenosis has no hemodynamic significance, but recent studies of regional cerebral blood flow have indicated that this occurs in a few cases. Traditionally, TIA are not considered to cause cerebral damage, but CT-studies have revealed a number of silent infarcts and rCBF measurements have shown even more persistent abnormalities of blood flow. In classic migraine, alterations of rCBF are completely different, indicating a mechanism progressing in the cerebral cortex, probably the spreading depression of Leao. Similar blood flow changes are not seen in common migraine, where tomographic rCBF determinations have been normal.

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Regional cerebral blood flow in chronic stroke patients.

Stroke ◽

10.1161/01.str.24.1.94 ◽

1993 ◽

Vol 24 (1) ◽

pp. 94-99 ◽

Cited By ~ 14

Author(s):

G Rodriguez ◽

F Nobili ◽

F De Carli ◽

S Francione ◽

S Marenco ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Chronic Stroke ◽

Regional Cerebral Blood ◽

Stroke Patients

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Blood Flow Differences Between Leuko-araiosis with and without Lacunar Infarction

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100033527 ◽

1998 ◽

Vol 25 (1) ◽

pp. 70-75 ◽

Cited By ~ 9

Author(s):

Minoru Oishi ◽

Yoko Mochizuki ◽

Toshiaki Takasu

Keyword(s):

Blood Flow ◽

Cerebral Cortex ◽

Cerebral Blood Flow ◽

White Matter ◽

Regional Cerebral Blood Flow ◽

Lacunar Infarction ◽

Cerebral White Matter ◽

Control Group ◽

Regional Cerebral Blood ◽

Blood Flows

ABSTRACT:Background:The present study was designed to find the differences in regional cerebral blood flow and cerebrovascular acetazolamide reactivity between leuko-araiosis with and without lacunar infarction.Methods:Fifteen cases of leuko-araiosis with lacunar infarction, 15 cases of leuko-araiosis without lacunar infarction and 15 age-matched controls in which leuko-araiosis and cerebrovascular diseases are absent (control group) were studied. The regional cerebral blood flow was measured using the stable xenon computed tomography method before and 20 minutes after intravenous injection of 17 mg/kg acetazolamide.Results:The blood flows in the leuko-araiosis area and the lacunar area were significantly lower than the blood flow in the cerebral white matter. The blood flows in the cerebral cortex and the cerebral white matter were significantly lower in the leuko-araiosis with lacunar infarction group than in the leuko-araiosis without lacunar infarction group and the control group. The cerebrovascular acetazolamide reactivity in the leuko-araiosis area and the lacunar area was significantly lower than that in the cerebral white matter. The cerebrovascular acetazolamide reactivity in the cerebral cortex and the cerebral white matter was significantly lower in the leuko-araiosis with lacunar infarction group than in the leuko-araiosis without lacunar infarction group and the control group.Conclusions:The degree of arteriolosclerosis is considered to be more severe and the rate of association of hypertension was higher in leuko-araiosis with lacunar infarction than in leuko-araiosis without lacunar infarction.

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