Did COVID-19 Pandemic Change People’s Physical Activity Distribution, Eating, and Alcohol Consumption Habits as well as Body Mass Index?

This cross-sectional study aimed to evaluate whether COVID-19 had an impact on people’s (aged 18–74) physical activity distribution, eating, and alcohol consumption habits as well as body mass index. We interviewed 6369 people (4545 women and 1824 men) in Lithuania before the COVID-19 pandemic started and 2392 during COVID-19 (1856 women and 536 men). They were aged 18–74 years. We found that both genders had not stopped their physical activity (PA) completely because of lockdown imitations (for example, prohibition from attending sport clubs), but they started doing different physical exercises at sport clubs. We determined the PA distribution according to the Danish Physical Activity Questionnaire (DPAQ). Despite increases in independent PA and the quantity of light PA, the amount of total energy used in metabolic equivalent of task (MET) units per day decreased significantly for both genders irrespective of age. Although the amounts of sedentary behavior, moderate PA (MPA), vigorous PA (VPA) or a combination of MPA and VPA (MVPA) did not change significantly. Surprisingly, lockdown reduced the duration of sleep for older women but increased their amount of intense VPA (>6 METs). However, the amount of intense VPA decreased for men. Both genders reported overeating less during the pandemic than before it, but did not start consuming more alcohol, and their body mass index did not change. Thus, the COVID-19 in Lithuania represented ‘good stress’ that mobilized these individuals to exercise more independently and overeat less.

Radiological characterization of a German pressurized water reactor based on a highly resolved method for activity analysis and dose rate calculation

The amendment to the atomic act in 2011 results to phase out nuclear energy in Germany until the end of 2022. Subsequently, the licensee of the nuclear power plant is responsible for decommissioning and dismantling. During operation, activation of structures near the core of the reactor occur which govern the amount of radioactive waste, the dose rate distribution and dismantling strategies. Thus, a detailed radiological characterization of in-core and out-core structures is required to optimize decommissioning processes regarding the quantification and minimization of radioactive waste, radiation protection and reducing radiation exposure. These objectives are achieved using an innovative and efficient method developed and applied at the Chair of Repository Safety (Lehrstuhl für Endlagersicherheit, ELS) RWTH Aachen University. Within the framework of the joint project „Development of a methodology for activity analysis and dose rate estimation“, funded by the Federal ministry of Education and Research, approaches the objective to develop a standardized and highly resolved method to calculate time-dependent activity of components and structures near the reactor core based on operating history of the nuclear power plant and neutron fluence distribution. The approach requires the development of a detailed model for Monte-Carlo simulations which provides the basis to neutron fluence, neutron spectra and radiation transport simulations. To calculate the nuclide specific 3-Dimensional (3D) activity distribution of the entire facility, a facility-dependent activation cross section library is produced which focuses on recent nuclear databases (ENDF/B-VIII.0). A highly resolved and space-dependent 3D activity distribution of the entire facility is obtained using a modular program package, developed at ELS, including the activation code ORIGEN2. The results are produced in the form of detailed 3D activity maps. The source terms are generated on the basis of the space-dependent 3D activity distribution using an additional module of the program package. The combination of recent nuclear databases focusing on ENDF/B-VII.1 and complemented by JEFF-3.3 ensures a comprehensive characterisation of source terms. Subsequently, source terms are prepared for 3D radiation transport simulation using the Monte-Carlo method and the computer code MCNP. The simulations are conducted separately for each individual component obtaining the partial contribution of all in-core and out-core structures as well as the dose rate distribution of the entire facility. Similar to the activity calculation, the simulation results are used to generate 3D gamma flux and dose rate maps using the graphic module of the whole program system. On the basis of the radiological characterisation and in view of a high-level radiation protection these maps allow the optimum planning and realisation of the decommissioning and dismantling process of the nuclear power plant.

Idea of an experimental technique for quantitative passive gamma emission tomography on irradiated nuclear fuel assemblies

An idea is presented in which passive gamma emission tomography of irradiated nuclear fuel is developed to enable quantitative information of the spatial activity distribution of selected isotopes within the fuel rods of the assembly. The idea is based on using well-known calibration sources mounted in the measurement device during measurement. The image reconstruction would include the sources, thereby enable quantification of the activity distribution. Should the idea be proven viable, the outcome would be valuable to the global community dealing with characterisation of nuclear fuel in terms of safety, security, safeguards and fuel development.

Red Blood Cell Proteasome in Beta-Thalassemia Trait: Topology of Activity and Networking in Blood Bank Conditions

Proteasomes are multi-catalytic complexes with important roles in protein control. Their activity in stored red blood cells (RBCs) is affected by both storage time and the donor’s characteristics. However, apart from their abundancy in the membrane proteome, not much is known about their topology, activity, and networking during the storage of RBCs from beta-thalassemia trait donors (βThal+). For this purpose, RBC units from fourteen βThal+ donors were fractionated and studied for proteasome activity distribution and interactome through fluorometric and correlation analyses against units of sex- and aged-matched controls. In all the samples examined, we observed a time-dependent translocation and/or activation of the proteasome in the membrane and a tight connection of activity with the oxidative burden of cells. Proteasomes were more active in the βThal+ membranes and supernatants, while the early storage networking of 20S core particles and activities showed a higher degree of connectivity with chaperones, calpains, and peroxiredoxins, which were nonetheless present in all interactomes. Moreover, the βThal+ interactomes were specially enriched in kinases, metabolic enzymes, and proteins differentially expressed in βThal+ membrane, including arginase-1, piezo-1, and phospholipid scramblase. Overall, it seems that βThal+ erythrocytes maintain a considerable “proteo-vigilance” during storage, which is closely connected to their distinct antioxidant dynamics and membrane protein profile.

Statistical parametric mapping of three-dimensional local activity distribution of skeletal muscle using magnetic resonance imaging (MRI)

Analysis of the internal local activity distribution in human skeletal muscles is important for managing muscle fatigue/pain and dysfunction. However, no method is established for three-dimensional (3D) statistical analysis of features of activity regions common to multiple subjects during voluntary motor tasks. We investigated the characteristics of muscle activity distribution from the data of ten healthy subjects (29 ± 1 year old, 2 women) during voluntary teeth clenching under two different occlusal conditions by applying spatial normalization and statistical parametric mapping (SPM) to analysis of muscle functional magnetic resonance imaging (mfMRI) using increase in transverse relaxation time (T2) of the skeletal muscle induced by exercise. The expansion of areas with significant T2 increase was observed in the masticatory muscles after clenching with molar loss comparing with intact dentition. The muscle activity distribution characteristics common to a group of subjects, i.e., the active region in the temporal muscle ipsilateral to the side with the molar loss and medial pterygoid muscle contralateral to the side with the molar loss, were clarified in 3D by applying spatial normalization and SPM to mfMRI analysis. This method might elucidate the functional distribution within the muscles and the localized muscular activity related to skeletal muscle disorders.

Ecogenetic monitoring of ionizing radiation for radon-hazardous territories

This work is devoted to studying the alpha activity distribution of natural radionuclides in boarding schools located near zones of tectonic faults. There are many tectonic faults in the Almaty and this is the basis for referring the southern capital of Kazakhstan to the radon-hazardous territories. As a result of radiometric measurements a 2D-topology of the alpha-radiation flux density distribution from the distance to the tectonic fault was found. Based on the measurements results the coefficient of radon concentration from the distance to the tectonic rupture was found. Using the obtained pattern, it is possible to plot the dependence of volumetric alpha activity for other schools, if their distances from the tectonic fault are known. In addition, interest in biomedical and ecogenetic effects of radon and its decay products has grown considerably in the last few years. These effects have been investigated in biotests on Drosophila’s two systems. It was found that alpha-particles, with the help of which the situation in radon-hazardous territories was simulated, possess mutagenic influence manifested mainly in formation of morphoses or deformities.

THE DOUNREAY FAST REACTOR VAULT CHARACTERISATION USING THE MONTE CARLO N-PARTICLE CODE AS A TOOL TO SUPPORT DECOMMISSIONING PLANNING

A combined empirical and theoretical characterisation approach was taken in order to investigate the activity distribution and inventory in the Dounreay Fast Reactor (DFR) vault, so as to aid with the decommissioning and waste management strategy of the cooling circuits located within the shielded vault. The DFR vault is a no-man access, shielded void, which surrounds the reactor core and the graphite shield. Empirical data was collected through various Non-Destructive Assay methods, utilising all available accesses into the reactor vault. This collection of information was then used to make a first assumption about the activity distribution within the vault; this was then included into a MCNP model of the vault as the source terms. The model was run and a dose rate map of the vault obtained, and compared to the empirical dose rate data previously gathered in the accessible penetrations in the vault; the model was altered until a satisfactory agreement was obtained between theoretical and measured data. Once this was obtained then, the model was used to provide an estimate of the activity inventory within the vault, and specifically within the various reactor components.

Profiling single-cell level phagocytic activity distribution with blood lactate levels

Investigating the relationship between neutrophil phagocytic activity and blood lactate levels by employing single-cell data.

Combined abnormal muscle activity and pain-related factors affect disability in patients with chronic low back pain: An association rule analysis

Objectives In patients with chronic low back pain (CLBP), reduced lumbar flexion-relaxation and reduced variability of muscle activity distribution are reported as abnormal muscle activity. It is not known how abnormal muscle activity and pain-related factors are related to CLBP-based disability. Here, we performed an association rule analysis to investigated how CLBP disability, muscle activity, and pain-related factors in CLBP patients are related. Methods Surface electromyographic signals were recorded from over the bilateral lumbar erector spinae muscle with four-channel electrodes from 24 CLBP patients while they performed a trunk flexion re-extension task. We calculated the average value of muscle activities of all channels and then calculated the flexion relaxation ratio (FRR) and the spatial variability of muscle activities. We also assessed the pain-related factors and CLBP disability by a questionnaire method. A clustering association rules analysis was performed to determine the relationships among pain-related factors, the FRR, and the variability of muscle activity distribution. Results The association rules of severe CLBP disability were divisible into five classes, including ‘low FRR-related rules.’ The rules of the mild CLBP disability were divisible into four classes, including ‘high FRR-related rules’ and ‘high muscle variability-related rules.’ When we combined pain-related factors with the FRR and muscle variability, the relationship between abnormal FRR/muscle variability and CLBP disability became stronger. Discussion Our findings thus highlight the importance of focusing on not only the patients’ pain-related factors but also the abnormal motor control associated with CLBP, which causes CLBP disability.