scholarly journals Blood Flow Differences Between Leuko-araiosis with and without Lacunar Infarction

1998 ◽  
Vol 25 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Minoru Oishi ◽  
Yoko Mochizuki ◽  
Toshiaki Takasu
Keyword(s):  
Blood Flow ◽  
Cerebral Cortex ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Regional Cerebral Blood Flow ◽  
Lacunar Infarction ◽  
Cerebral White Matter ◽  
Control Group ◽  
Regional Cerebral Blood ◽  
Blood Flows

ABSTRACT:Background:The present study was designed to find the differences in regional cerebral blood flow and cerebrovascular acetazolamide reactivity between leuko-araiosis with and without lacunar infarction.Methods:Fifteen cases of leuko-araiosis with lacunar infarction, 15 cases of leuko-araiosis without lacunar infarction and 15 age-matched controls in which leuko-araiosis and cerebrovascular diseases are absent (control group) were studied. The regional cerebral blood flow was measured using the stable xenon computed tomography method before and 20 minutes after intravenous injection of 17 mg/kg acetazolamide.Results:The blood flows in the leuko-araiosis area and the lacunar area were significantly lower than the blood flow in the cerebral white matter. The blood flows in the cerebral cortex and the cerebral white matter were significantly lower in the leuko-araiosis with lacunar infarction group than in the leuko-araiosis without lacunar infarction group and the control group. The cerebrovascular acetazolamide reactivity in the leuko-araiosis area and the lacunar area was significantly lower than that in the cerebral white matter. The cerebrovascular acetazolamide reactivity in the cerebral cortex and the cerebral white matter was significantly lower in the leuko-araiosis with lacunar infarction group than in the leuko-araiosis without lacunar infarction group and the control group.Conclusions:The degree of arteriolosclerosis is considered to be more severe and the rate of association of hypertension was higher in leuko-araiosis with lacunar infarction than in leuko-araiosis without lacunar infarction.

scholarly journals Regional Cerebral Blood Flow in Patients with Aneurysms: Estimation by Xenon 133 Inhalation

1978 ◽  
Vol 5 (3) ◽  
pp. 301-305 ◽  
Author(s):  
Bryce Weir ◽  
Devidas Menon ◽  
Thomas Overton
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Values ◽  
Regional Distribution ◽  
Progressive Increase ◽  
Control Group ◽  
Regional Cerebral Blood ◽  
Progressive Reduction ◽  
Distribution Of Flow

SUMMARY:Seventy six regional cerebral blood flow (rCBF) studies were conducted on 32 patients who had a total of 39 aneurysms. Twenty three of these patients were studied pre- and post-operatively. Normal values were obtained from a control group of 33 subjects, each of whom underwent one rCBF study. Flow was reduced following subarachnoid hemorrhage (SAH); it increased significantly postoperatively. Lower flows were associated with poorer clinical grades. There was a greater variation in regional distribution of flow immediately following SAH than in normals or in patients who had recovered from the acute phase. rCBF studies correlated with CT scans demonstrated that a progressive increase in ventricular size was accompanied by a progressive reduction in flow. In addition, intraventricular hemorrhage (IVH) was associated with a significant reduction in cerebral blood flow (CBF). No significant correlation between CBF and spasm was demonstrable.

Effects of temperature and anoxia on regional cerebral blood flow in turtles

1992 ◽  
Vol 262 (3) ◽  
pp. R538-R541
Author(s):  
P. E. Bickler
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Brain Regions ◽  
Platinum Electrodes ◽  
Regional Cerebral Blood ◽  
Blood Flows ◽  
Effects Of Temperature ◽  
Kinetics Of ◽  
Hydrogen Clearance

Regional cerebral blood flow (CBF) was measured in isoflurane-anesthetized turtles (Pseudemys scripta) by the hydrogen clearance method. Teflon-coated platinum electrodes (25 microns) were implanted in the olfactory bulbs, midcerebral cortex and cerebellum in eight adult turtles. The electrodes were voltage clamped at +0.30 V relative to a Ag-AgCl electrode implanted in the dorsal neck muscles. Washout kinetics of H2 gas administered via controlled ventilation was used to calculate local blood flow for electrodes exhibiting monoexponential washout kinetics of hydrogen (92 of 104 determinations). Data were obtained in animals with body temperatures of 15, 25, and 35 degrees C under normocapnic conditions during ventilation with 21% O2 and during ventilation with 100% N2. During normoxia, mean blood flows were 1.9 +/- 0.8, 5.0 +/- 1.9, and 6.1 +/- 1.3 (+/- SD) ml.100 g-1.min-1 at 15, 25, and 35 degrees C, respectively. There were no differences between CBF values in the different brain regions. During 1-3 h of anoxia, CBF was 3.0 +/- 2.1, 7.0 +/- 3.7, and 6.6 +/- 2.9 ml.100 g-1.min-1 at 15, 25, and 35 degrees C, respectively (normoxia-anoxia difference not statistically different). Hypercarbia (ventilation with 10-20% CO2 in air or N2), or the transition from anoxia to normoxia, increased CBF up to 80% at each of these temperatures. Maintenance of CBF during anoxia likely contributes to the anoxia tolerance of the turtle brain.

Effects of Olprinone, a Phosphodiesterase 3 Inhibitor, on Regional Cerebral Blood Flow of Cerebral Cortex in Stroke Patients

2001 ◽  
Vol 37 (4) ◽  
pp. 375-380 ◽  
Author(s):  
Kazushi Yukiiri ◽  
Katsufumi Mizushige ◽  
Takashi Ueda ◽  
Yoshihiro Nishiyama ◽  
Tohru Aoyama ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Cortex ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Stroke Patients ◽  
Phosphodiesterase 3

scholarly journals Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus

Brain ◽  
2004 ◽  
Vol 127 (5) ◽  
pp. 965-972 ◽  
Author(s):  
Shahan Momjian ◽  
Brian K. Owler ◽  
Zofia Czosnyka ◽  
Marek Czosnyka ◽  
Alonso Pena ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Normal Pressure Hydrocephalus ◽  
Regional Cerebral Blood Flow ◽  
Normal Pressure ◽  
Regional Cerebral Blood

Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins

1987 ◽  
Vol 67 (2) ◽  
pp. 278-283 ◽  
Author(s):  
Laura R. Ment ◽  
William B. Stewart ◽  
Charles C. Duncan ◽  
Bruce R. Pitt ◽  
Judith Cole
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
White Matter ◽  
Regional Cerebral Blood Flow ◽  
Ventilatory Support ◽  
Periventricular White Matter ◽  
Regional Cerebral Blood ◽  
Content Type ◽  
Carbon 14

✓ Asphyxia is the most common cause of severe brain injury in very young children, and frequently results in lesions of the periventricular white matter in addition to other neuropathological changes. This study examines the effects of asphyxia on regional cerebral blood flow (rCBF) and the role of prostaglandins (PG's) in its control in the newborn beagle pup. Pups were anesthetized, tracheotomized, paralyzed, artificially ventilated, and randomly assigned to two groups: asphyxial insult produced by discontinuing ventilatory support, and no insult. Experiments for carbon-14-iodoantipyrine autoradiographic determination of rCBF and regional cerebral PG determination were performed on separate groups of pups. These studies demonstrated a significant increase in cortical gray PGE2 levels at a time when rCBF was significantly impaired in response to severe asphyxial insult. No such increase was noted in the periventricular white matter zones.

scholarly journals Changes in regional cerebral blood flow due to cognitive activation among patients with schizophrenia

2000 ◽  
Vol 177 (3) ◽  
pp. 222-228 ◽  
Author(s):  
B. K. Toone ◽  
C. I. Okocha ◽  
K. Sivakumar ◽  
G. M. Syed
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Anterior Cingulate ◽  
Control Group ◽  
Wisconsin Card Sort Test ◽  
Card Sorting ◽  
Regional Cerebral Blood

BackgroundThe regional cerebral blood flow (rCBF) response to the Wisconsin Card Sort Test (WCST) has been used to assess the functional integrity of the prefrontal cortex in patients with schizophrenia.AimsIn this study, patients were divided into two groups according to whether they had made few or many perseverative errors on a modified version of the WCST. A control group consisted of normal volunteers. The groups were then compared with respect to rCBF response to WCST activation.MethodrCBF was measured during administration of a modified version of the WCST and during a card sorting control task, using single photon emission computerised tomography (SPECT).ResultsPerformance of the modified WCST was associated with a widespread and substantial increase in rCBF, particularly in the frontal region. The poorly performing group of patients with schizophrenia showed only a modest increase in rCBF in the left anterior cingulate region.ConclusionSubjects with schizophrenia are able to respond to specific neuropsychological challenge with activation of the frontal regions.

rCBF After Tia and during Migraine Attacks

Cephalalgia ◽  
1985 ◽  
Vol 5 (2_suppl) ◽  
pp. 43-46 ◽  
Author(s):  
Jes Olesen ◽  
Sissel Vorstrup ◽  
Martin Lauritzen
Keyword(s):  
Blood Flow ◽  
Cerebral Cortex ◽  
Cerebral Blood Flow ◽  
Carotid Stenosis ◽  
Regional Cerebral Blood Flow ◽  
Spreading Depression ◽  
Cerebral Damage ◽  
Regional Cerebral Blood ◽  
Flow Changes ◽  
Ct Studies

TIA is usually caused by embolism from a carotid stenosis. The stenosis has no hemodynamic significance, but recent studies of regional cerebral blood flow have indicated that this occurs in a few cases. Traditionally, TIA are not considered to cause cerebral damage, but CT-studies have revealed a number of silent infarcts and rCBF measurements have shown even more persistent abnormalities of blood flow. In classic migraine, alterations of rCBF are completely different, indicating a mechanism progressing in the cerebral cortex, probably the spreading depression of Leao. Similar blood flow changes are not seen in common migraine, where tomographic rCBF determinations have been normal.

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