Bladder Injury Model Induced in Rats by Exposure to Protamine Sulfate Followed by Bacterial Endotoxin

1996 ◽  
pp. 1133-1138 ◽  
Author(s):  
Paul C. Stein ◽  
H. Pham ◽  
T. Ito ◽  
C. L. Parsons
1996 ◽  
Vol 155 (3) ◽  
pp. 1133-1138 ◽  
Author(s):  
Paul C. Stein ◽  
H. Pham ◽  
T. Ito ◽  
C.L. Parsons

2006 ◽  
Vol 175 (4S) ◽  
pp. 63-63
Author(s):  
Nicholas Power ◽  
John Downie ◽  
Leslie Ingraham ◽  
Rekha Gupta ◽  
Adam Power

2013 ◽  
Vol 189 (1) ◽  
pp. 343-351 ◽  
Author(s):  
Kristina M. Stemler ◽  
Lara W. Crock ◽  
H. Henry Lai ◽  
Jason C. Mills ◽  
Robert W. Gereau ◽  
...  

2008 ◽  
Vol 81 (3) ◽  
pp. 347-352
Author(s):  
Abdurrahman Özgür ◽  
Fikret Fatih Önol ◽  
Feriha Ercan ◽  
Tufan Tarcan
Keyword(s):  

2017 ◽  
Vol 313 (2) ◽  
pp. F155-F162 ◽  
Author(s):  
Pradeep Tyagi ◽  
Joseph J. Janicki ◽  
T. Kevin Hitchens ◽  
Lesley M. Foley ◽  
Mahendra Kashyap ◽  
...  

Here, we tested whether combined contrast-enhanced magnetic resonance imaging (CCE-MRI), using a mixture of gadolinium- and iron oxide-based contrast agents, can segment the bladder wall from the bladder lumen. CCE-MRI relies on the differences in particle size and contrast mechanisms of two agents for improved image contrast. Under isoflurane anesthesia, T1-weighted imaging of adult female Sprague-Dawley rat bladder was performed using standard turbospin echo sequences at 7 Tesla, before and after transurethral instillation of 0.3 ml of single-contrast MRI or CCE-MRI composed of 0.4–64 mM of gadolinium chelate (Gd-DTPA/Gadavist) and 5 mM ferumoxytol. Bladder wall contrast was assessed in the control group exposed to saline and in the bladder injury group exposed to 0.5 ml of protamine sulfate (10 mg/ml) for 30 min. CCE-MRI following instillation of 0.4–4 mM Gd-DTPA and 5 mM ferumoxytol mixture achieved segmentation between the bladder lumen and bladder wall. Hyperintensity in the bladder wall combined with hypointensity in the lumen is consistent with the increased diffusion of the dissolved Gd-DTPA and simultaneous localization of the larger nanoparticles of ferumoxytol in the lumen. The normalized hyperintense signal in the bladder wall increased from 0.46 ± 0.07 in control group to 0.73 ± 0.14 in the protamine sulfate-exposed group ( P < 0.0001). CCE-MRI following instillation of contrast mixture identifies bladder wall changes likely associated with bladder injury with improved image contrast.


1999 ◽  
pp. 43 ◽  
Author(s):  
George Somogyi ◽  
Michael B. Chancellor ◽  
Teruhiko Yokoyama ◽  
Naoki Yoshimura ◽  
William C. de Groat ◽  
...  
Keyword(s):  

2003 ◽  
Vol 169 (4) ◽  
pp. 1564-1568 ◽  
Author(s):  
ŞULE ÇETINEL ◽  
FERIHA ERCAN ◽  
SERAP ŞIRVANCI ◽  
ÖZER ŞEHIRLI ◽  
YASEMIN ERSOY ◽  
...  

2002 ◽  
Vol 7 (4) ◽  
pp. 8-10
Author(s):  
Christopher R. Brigham ◽  
Leon H. Ensalada

Abstract Recurrent radiculopathy is evaluated by a different approach in the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fifth Edition, compared to that in the Fourth Edition. The AMA Guides, Fifth Edition, specifies several occasions on which the range-of-motion (ROM), not the Diagnosis-related estimates (DRE) method, is used to rate spinal impairments. For example, the AMA Guides, Fifth Edition, clarifies that ROM is used only for radiculopathy caused by a recurrent injury, including when there is new (recurrent) disk herniation or a recurrent injury in the same spinal region. In the AMA Guides, Fourth Edition, radiculopathy was rated using the Injury Model, which is termed the DRE method in the Fifth Edition. Also, in the Fourth Edition, for the lumbar spine all radiculopathies resulted in the same impairment (10% whole person permanent impairment), based on that edition's philosophy that radiculopathy is not quantifiable and, once present, is permanent. A rating of recurrent radiculopathy suggests the presence of a previous impairment rating and may require apportionment, which is the process of allocating causation among two or more factors that caused or significantly contributed to an injury and resulting impairment. A case example shows the divergent results following evaluation using the Injury Model (Fourth Edition) and the ROM Method (Fifth Edition) and concludes that revisions to the latter for rating permanent impairments of the spine often will lead to different results compared to using the Fourth Edition.


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