A 2-D finite element model of human cochlea is established in this paper. This model includes the structure of oval window, round window, basilar membrane and cochlear duct which is filled with fluid. The basilar membrane responses are calculated with sound input on the oval window membrane. In order to study the effects of helicotrema on basilar membrane response, three different helicotrema dimensions are set up in the FE model. A two-way fluid-structure interaction numerical method is used to compute the responses in the cochlea. The influence of the helicotrema is acquired and the frequency selectivity of the basilar membrane motion along the cochlear duct is predicted. These results agree with the experiments and indicate much better results are obtained with appropriate helicotrema size.