EXCESS POSTEXERCISE OXYGEN CONSUMPTION (EPOC) FOLLOWING AEROBIC EXERCISE TRAINING

Literature examining the effects of aerobic exercise training on excess postexercise oxygen consumption (EPOC) is sparse. In this study, 9 male participants (19–32 yr) trained (EX) for 12 wk, and 10 in a control group (CON) maintained normal activity. VO2max, rectal temperature (Tre), epinephrine, norepinephrine, free fatty acids (FFA), insulin, glucose, blood lactate (BLA), and EPOC were measured before (PRE) and after (POST) the intervention. EPOC at PRE was measured for 120 min after 30 min of treadmill running at 70% VO2max. EX completed 2 EPOC trials at POST, i.e., at the same absolute (ABS) and relative (REL) intensity; 1 EPOC test for CON served as both the ABS and REL trial because no significant change in VO2max was noted. During the ABS trial, total EPOC decreased significantly (p < .01) from PRE (39.4 ± 3.6 kcal) to POST (31.7 ± 2.2 kcal). Tre, epinephrine, insulin, glucose, and BLA at end-exercise or during recovery were significantly lower and FFA significantly higher after training. Training did not significantly affect EPOC during the REL trial; however, epinephrine was significantly lower, and norepinephrine and FFA, significantly higher, at endexercise after training. Results indicate that EPOC varies as a function of relative rather than absolute metabolic stress and that training improves the efficiency of metabolic regulation during recovery from exercise. Mechanisms for the decreased magnitude of EPOC in the ABS trial include decreases in BLA, Tre, and perhaps epinephrine-mediated hepatic glucose production and insulin-mediated glucose uptake.

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Sequence variation in hypoxia-inducible factor 1α (HIF1A): association with maximal oxygen consumption

Physiological Genomics ◽

10.1152/physiolgenomics.00061.2003 ◽

2003 ◽

Vol 15 (1) ◽

pp. 20-26 ◽

Cited By ~ 53

Author(s):

Steven J. Prior ◽

James M. Hagberg ◽

Dana A. Phares ◽

Michael D. Brown ◽

Liane Fairfull ◽

...

Keyword(s):

Oxygen Consumption ◽

Exercise Training ◽

Aerobic Exercise ◽

Sequence Variation ◽

Hypoxia Inducible Factor ◽

Maximal Oxygen Consumption ◽

Allele Frequencies ◽

Aerobic Exercise Training ◽

Before And After ◽

Specific Allele

Hypoxia-inducible factor 1 (HIF1) is a DNA transcription factor composed of two subunits, one of which is regulated by hypoxia (HIF1α, encoded by HIF1A). Genes regulated by HIF1 are involved in the processes of angiogenesis, erythropoiesis, and metabolism, making HIF1A a candidate gene in establishing maximal oxygen consumption (V˙o2 max) before and after aerobic exercise training. The purpose of the present study was to screen HIF1A for sequence variation and determine whether such variation is associated with V˙o2 max before and after aerobic exercise training. A total of 233 Caucasian and African-American subjects were available for screening of HIF1A and determination of allele frequencies, with 155 of those subjects used to study V˙o2 max in relation to identified variants. We measured V˙o2 max before and after 24 wk of aerobic exercise training. Screening revealed several rare and common polymorphisms in HIF1A with race-specific allele frequencies. African Americans with AT or TT genotype at the A−2500T locus exhibited significantly lower baseline V˙o2 max compared with those of AA genotype (21.9 ± 0.99 vs. 25.1 ± 1.0, P = 0.03). An age by P582S (C/T) genotype interaction was observed in Caucasian subjects, such that those of CT or TT genotype exhibited significantly lower change in V˙o2 max after training than those of CC genotype when compared at ages 65 and 60 yr, but not at age 55 yr. No other significant differences were noted among genotype groups at the A−2500T, P582S, or T+140C sites. Based on these findings, we conclude that HIF1A sequence variation is associated with V˙o2 max before and after aerobic exercise training in older humans.

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Effects of upper extremity aerobic exercise training on oxygen consumption, exercise capacity, dyspnea and quality of life in patients with pulmonary arterial hypertension

Heart & Lung ◽

10.1016/j.hrtlng.2020.04.006 ◽

2020 ◽

Vol 49 (5) ◽

pp. 564-571

Author(s):

Burcu Camcıoğlu Yılmaz ◽

Meral Boşnak Güçlü ◽

Müşerrefe Nur Keleş ◽

Gülten Aydoğdu Taçoy ◽

Atiye Çengel

Keyword(s):

Quality Of Life ◽

Oxygen Consumption ◽

Pulmonary Arterial Hypertension ◽

Exercise Training ◽

Arterial Hypertension ◽

Aerobic Exercise ◽

Exercise Capacity ◽

Aerobic Exercise Training ◽

Pulmonary Arterial

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DNA sequence variation in the promoter region of theVEGFgene impactsVEGFgene expression and maximal oxygen consumption

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.01033.2005 ◽

2006 ◽

Vol 290 (5) ◽

pp. H1848-H1855 ◽

Cited By ~ 67

Author(s):

Steven J. Prior ◽

James M. Hagberg ◽

Chad M. Paton ◽

Larry W. Douglass ◽

Michael D. Brown ◽

...

Keyword(s):

Gene Expression ◽

Oxygen Consumption ◽

Exercise Training ◽

Aerobic Exercise ◽

Promoter Region ◽

Maximal Oxygen Consumption ◽

Aerobic Exercise Training ◽

Vegf Gene ◽

Before And After ◽

Artery Disease

In its role as an endothelial cell proliferation and migration factor, vascular endothelial growth factor (VEGF) can affect peripheral circulation and therefore impact maximal oxygen consumption (V̇o2 max). Because of the role of VEGF, and because variation in the VEGF gene has the ability to alter VEGF gene expression and VEGF protein level, we hypothesized that VEGF gene polymorphisms are related to VEGF gene expression in human myoblasts and V̇o2 maxbefore and after aerobic exercise training. We analyzed the effects of the VEGF −2578/−1154/−634 promoter region haplotype on VEGF gene expression by using a luciferase reporter assay in cultured human myoblasts and found that the AAG and CGC haplotypes resulted in significantly higher hypoxia-stimulated VEGF gene expression than the AGG and CGG haplotypes. Consistent with these results, we found that individuals with at least one copy of the AAG or CGC haplotype had higher V̇o2 maxbefore and after aerobic exercise training than did subjects with only the AGG and/or CGG haplotype. In conclusion, we found that VEGF −2578/−1154/−634 haplotype impacts VEGF gene expression in human myoblasts and is associated with V̇o2 max. These results have potential implications for aerobic exercise training and may prove relevant in the study of pathological conditions that can be affected by angiogenesis, such as coronary artery disease and peripheral artery disease.

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