A36 PET/CT scan with 18F-FDOPA in the diagnosis of congenital hyperinsulinism in children

2006 ◽  
Vol 27 (3) ◽  
pp. 290
Author(s):  
A. Zonoozi ◽  
P.A. Beaumont ◽  
G. Plant ◽  
K. Hussain ◽  
J.R.W. Hall
Keyword(s):  
Ct Scan ◽  
Congenital Hyperinsulinism ◽  
Pet Ct ◽  
Pet Ct Scan

scholarly journals Paternally inherited ABCC8 mutation causing diffuse congenital hyperinsulinism

2013 ◽  
Vol 2013 ◽  
Author(s):  
Suresh Chandran ◽  
Fabian Yap Kok Peng ◽  
Victor Samuel Rajadurai ◽  
Yap Te Lu ◽  
Kenneth T E Chang ◽  
...  
Keyword(s):  
Ct Scan ◽  
Severe Hypoglycaemia ◽  
Congenital Hyperinsulinism ◽  
List Type ◽  
Focal Lesions ◽  
Hyperinsulinaemic Hypoglycaemia ◽  
Partial Pancreatectomy ◽  
Diffuse Disease ◽  
Pet Ct ◽  
Pet Ct Scan

Summary background: Congenital hyperinsulinism (CHI) is a rare genetic disorder characterised by inappropriate insulin secretion in the face of severe hypoglycaemia. There are two histological subtypes of CHI namely diffuse and focal. Diffuse CHI is most common due to recessive mutations in ABCC8/KCNJ11 (which encode the SUR/KIR6.2 components of the pancreatic β-cell KATP channel) whereas focal CHI is due to a paternally inherited ABCC8/KCNJ11 mutation and somatic loss of heterozygosity for the 11p allele inside the focal lesion. Fluorine-18-l-dihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA-PET/CT) is used in the pre-operative localisation of focal lesions prior to surgery. Diffuse CHI if medically unresponsive will require a near total pancreatectomy whereas focal CHI will only require a limited lesionectomy, thus curing the patient from the hypoglycaemia. Aims: To report the first case of genetically confirmed CHI in Singapore from a heterozygous paternally inherited ABCC8 mutation. Methods/Results: A term male infant presented with severe hyperinsulinaemic hypoglycaemia (HH) after birth and failed medical treatment with diazoxide and octreotide. Genetic testing (paternally inherited mutation in ABCC8/p.D1472N) suggested focal disease, but due to the unavailability of 18F-DOPA-PET/CT to confirm focal disease, a partial pancreatectomy was performed. Interestingly, histology of the resected pancreatic tissue showed changes typical of diffuse disease. Conclusion: Heterozygous paternally inherited ABCC8/KCNJ11 mutations can lead to diffuse or focal CHI. Learning points HH is a cause of severe hypoglycaemia in the newborn period. Paternal mutations in ABCC8/KCNJ11 can lead to diffuse or focal disease. 18F-DOPA-PET/CT scan is the current imaging of choice for localising focal lesions. Gallium-68 tetra-aza-cyclododecane-N N′N″N-‴-tetra-acetate octreotate PET scan is not a useful imaging tool for localising focal lesions. The molecular mechanism by which a heterozygous ABCC8 mutation leads to diffuse disease is currently unclear. Focal lesions are curable by lesionectomy and so genetic studies in patients with HH must be followed by imaging using 18F-DOPA-PET/CT scan.

scholarly journals Accuracy of PET/CT Scan in the diagnosis of the focal form of congenital hyperinsulinism

2013 ◽  
Vol 48 (2) ◽  
pp. 388-393 ◽  
Author(s):  
Pablo Laje ◽  
Lisa J. States ◽  
Hongming Zhuang ◽  
Susan A. Becker ◽  
Andrew A. Palladino ◽  
...  
Keyword(s):  
Ct Scan ◽  
Congenital Hyperinsulinism ◽  
Pet Ct ◽  
Pet Ct Scan

Congenital hyperinsulinism: [18F]DOPA PET/CT scan of a focal lesion in the head of the pancreas

2007 ◽  
Vol 93 (2) ◽  
pp. F166-F166 ◽  
Author(s):  
R R Kapoor ◽  
C Gilbert ◽  
K Mohnike ◽  
O Blankenstein ◽  
F Fuechtner ◽  
...  
Keyword(s):  
Ct Scan ◽  
Focal Lesion ◽  
Congenital Hyperinsulinism ◽  
Pet Ct ◽  
Head Of The Pancreas ◽  
Pet Ct Scan

scholarly journals Congenital hyperinsulinism: [18F]DOPA PET/CT scan of a focal lesion in the head of the pancreas

2009 ◽  
Vol 2009 (feb04 1) ◽  
pp. bcr2007121178-bcr2007121178 ◽  
Author(s):  
R R Kapoor ◽  
C Gilbert ◽  
K Mohnike ◽  
O Blankenstein ◽  
F Fuechtner ◽  
...  
Keyword(s):  
Ct Scan ◽  
Focal Lesion ◽  
Congenital Hyperinsulinism ◽  
Pet Ct ◽  
Head Of The Pancreas ◽  
Pet Ct Scan

1596: Lymph Node Staging in Prostate Cancer by the use of 11C-CHOLIN-PET/CT Scan Imaging

2005 ◽  
Vol 173 (4S) ◽  
pp. 432-432
Author(s):  
Georg C. Bartsch ◽  
Norbert Blumstein ◽  
Ludwig J. Rinnab ◽  
Richard E. Hautmann ◽  
Peter M. Messer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Ct Scan ◽  
Lymph Node Staging ◽  
Pet Ct ◽  
Pet Ct Scan

Suspected osseous recurrence visualized on a 68Ga- DOTATATE PET/CT scan during the follow-up of a patient with a resected pulmonary carcinoid tumour

2011 ◽  
Vol 50 (05) ◽  
pp. N57-N59
Author(s):  
S. Geiger ◽  
S. Horster ◽  
A. R. Haug ◽  
A. Hausmann ◽  
M. Schlemmer ◽  
...  
Keyword(s):  
Ct Scan ◽  
Carcinoid Tumour ◽  
Pulmonary Carcinoid ◽  
Pet Ct ◽  
Pet Ct Scan

How to Do a PET/CT Scan and Not Glow in the Dark

MedEdPORTAL ◽  
2015 ◽  
Vol 11 (1) ◽  
Author(s):  
Srijaya Reddy ◽  
Ira Cohen
Keyword(s):  
Ct Scan ◽  
Pet Ct ◽  
Pet Ct Scan
Sign in / Sign up

Export Citation Format

Share Document