Effects of antiinflammatory drugs on arachidonic acid metabolites and cerebrospinal fluid proteins during infectious pneumococcal meningitis in rabbits

1987 ◽  
Vol 6 (12) ◽  
pp. 1153-1154
Author(s):  
J. L. KADURUGAMUWA ◽  
PHD B. HENGSTLER ◽  
O. ZAK
Keyword(s):  
Cerebrospinal Fluid ◽  
Arachidonic Acid ◽  
Pneumococcal Meningitis ◽  
Antiinflammatory Drugs ◽  
Cerebrospinal Fluid Proteins ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites

Effects of indomethacin and prostacyclin on isolated human pial arteries contracted by CSF from patients with aneurysmal SAH

1981 ◽  
Vol 55 (6) ◽  
pp. 877-883 ◽  
Author(s):  
Lennart Brandt ◽  
Bengt Ljunggren ◽  
Karl-Erik Andersson ◽  
Bengt Hindfelt ◽  
Tore Uski
Keyword(s):  
Cerebrospinal Fluid ◽  
Arachidonic Acid ◽  
Vessel Wall ◽  
Cerebral Arteries ◽  
Pial Arteries ◽  
Content Type ◽  
Cerebral Vasoconstriction ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites ◽  
Fine Print

✓ In small human cerebral arteries preincubated with indomethacin, contractions induced by cerebrospinal fluid (CSF), from patients with subarachnoid hemorrhage were markedly increased. Also contractions induced by noradrenaline, but not 5-hydroxytryptamine, were augmented. Prostacyclin and its metabolite 6-keto-prostaglandin (PG)E1 reversed the contractions induced by CSF, as well as by noradrenaline, 5-hydroxytryptamine, and PGF2α. The findings suggest that these substances are able to counteract the influence of vasoconstrictor material in hemorrhagic CSF. If the capacity to synthesize these “protective” arachidonic acid metabolites is reduced, the resulting imbalance between contractile and relaxant forces acting on the vessel wall may lead to sustained cerebral vasoconstriction.

Effects of newly arachidonic acid metabolites on microsomal Ca++ binding, uptake and release

1983 ◽  
Vol 26 (1) ◽  
pp. 13-21 ◽  
Author(s):  
P. Kutsky ◽  
J.R. Falck ◽  
G.B. Weiss ◽  
S. Manna ◽  
N. Chacos ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites ◽  
Uptake And Release
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