Effect of fever on the serum antibody response of Gambian children to Haemophilus influenzae type b conjugate vaccine

2000 ◽  
Vol 19 (5) ◽  
pp. 444-449 ◽  
Author(s):  
STANLEY USEN ◽  
PAUL MILLIGAN ◽  
CHANTAL ETHEVENAUX ◽  
BRIAN GREENWOOD ◽  
KIM MULHOLLAND
Keyword(s):  
Antibody Response ◽  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Serum Antibody ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Serum Antibody Response

Haemophilus influenzae Type b Capsular Polysaccharide Vaccine in Children: A Double-Blind Field Study of 100,000 Vaccinees 3 Months to 5 Years of Age in Finland

PEDIATRICS ◽  
1977 ◽  
Vol 60 (5) ◽  
pp. 730-737 ◽  
Author(s):  
Heikki Peltola ◽  
Helena Käythy ◽  
Aulikki Sivonen ◽  
P. Helena Mäkelä
Keyword(s):  
Antibody Response ◽  
Haemophilus Influenzae ◽  
Capsular Polysaccharide ◽  
Serum Antibody ◽  
Polysaccharide Vaccine ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Serum Antibody Response ◽  
Group A

A recently developed Haemophilus influenzae type b capsular polysaccharide vaccine was given to 48,977 children 3 months to 5 years of age; an equal number of children receiving group A meningococcal vaccine served as controls. The protection as well as serum antibody response was strongly age-dependent. Among children who had received the H. influenzae type b vaccine when 18 months of age or older, there were no cases of bacteremic disease caused by H. influenzae type b in the first year after vaccination. At the same time 11 such cases were seen in the control group of the same age, a highly significant difference. In the second year after vaccination two cases occurred in the H. influenzae type b-vaccinated group, five in the meningococcal-group A vaccinated group. No protection was seen among children who had been younger than 18 months when vaccinated, even if they received a booster dose of the vaccine. The serum antibody response to the H. influenzae type b polysaccharide, measured by radioimmunoassay, was poor in children below 18 months of age and good in those above it. No effect of the vaccine could be seen on the nasopharyngeal carriage of H. influenzae type b, which was approximately 6% in this age group. Adverse effects of the vaccine were mild.

scholarly journals Antibody response to Haemophilus influenzae type b tetanus conjugate vaccine with two doses given at 3 and 5 months of age

2002 ◽  
Vol 6 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Thaís Guimara˜es ◽  
Rosaˆngela R. Cereda ◽  
Paulo J. Bianchin ◽  
Aparecida T. Nagao ◽  
Magda C. Sampaio ◽  
...  
Keyword(s):  
Antibody Response ◽  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B
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