Characterization of the Serum Antibody Response to the Capsular Polysaccharide of Haemophilus influenzae Type b in Children with Invasive Infections

1992 ◽  
Vol 166 (6) ◽  
pp. 1335-1339 ◽  
Author(s):  
B. Trollfors ◽  
T. Lagergard ◽  
B. A. Claesson ◽  
E. Thornberg ◽  
J. Martinell ◽  
...  
Keyword(s):  
Antibody Response ◽  
Haemophilus Influenzae ◽  
Capsular Polysaccharide ◽  
Serum Antibody ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Serum Antibody Response ◽  
Invasive Infections

Haemophilus influenzae Type b Capsular Polysaccharide Vaccine in Children: A Double-Blind Field Study of 100,000 Vaccinees 3 Months to 5 Years of Age in Finland

PEDIATRICS ◽  
1977 ◽  
Vol 60 (5) ◽  
pp. 730-737 ◽  
Author(s):  
Heikki Peltola ◽  
Helena Käythy ◽  
Aulikki Sivonen ◽  
P. Helena Mäkelä
Keyword(s):  
Antibody Response ◽  
Haemophilus Influenzae ◽  
Capsular Polysaccharide ◽  
Serum Antibody ◽  
Polysaccharide Vaccine ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Serum Antibody Response ◽  
Group A

A recently developed Haemophilus influenzae type b capsular polysaccharide vaccine was given to 48,977 children 3 months to 5 years of age; an equal number of children receiving group A meningococcal vaccine served as controls. The protection as well as serum antibody response was strongly age-dependent. Among children who had received the H. influenzae type b vaccine when 18 months of age or older, there were no cases of bacteremic disease caused by H. influenzae type b in the first year after vaccination. At the same time 11 such cases were seen in the control group of the same age, a highly significant difference. In the second year after vaccination two cases occurred in the H. influenzae type b-vaccinated group, five in the meningococcal-group A vaccinated group. No protection was seen among children who had been younger than 18 months when vaccinated, even if they received a booster dose of the vaccine. The serum antibody response to the H. influenzae type b polysaccharide, measured by radioimmunoassay, was poor in children below 18 months of age and good in those above it. No effect of the vaccine could be seen on the nasopharyngeal carriage of H. influenzae type b, which was approximately 6% in this age group. Adverse effects of the vaccine were mild.

scholarly journals Different seroprevalences of antibodies against Neisseria meningitidis serogroup A and Haemophilus influenzae type b in Sudanese and Swedish children

1993 ◽  
Vol 110 (2) ◽  
pp. 307-316 ◽  
Author(s):  
M. A. M. Salih ◽  
H. Fredlund ◽  
S. Hugosson ◽  
L. Bodin ◽  
P. Olcén
Keyword(s):  
Haemophilus Influenzae ◽  
Neisseria Meningitidis ◽  
Endemic Area ◽  
Capsular Polysaccharide ◽  
Herd Immunity ◽  
Serum Antibody ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Antibody Assay

SUMMARYSampling of sera from 202 Sudanese and 124 Swedish children 1–14 years of age was conducted at the end of the 1980s presenting an opportunity to compare the seroprevalence of anti-Neisseria meningitidis (MC) serogroup A antibodies in an area immediately before outbreak of an epidemic (Sudan 1988) with a low endemic area (Sweden). An ELISA antibody assay was developed for detection of antibodies against capsular polysaccharide of MC serogroup A and Haemophilus influenzae type b (Hib). Serum antibody against MC serogroup A was found significantly more frequently in Sudanese than in Swedish children. This indicates that factors other than herd immunity, as measured by serum antibodies against MC serogroup A polysaccharide, are important for avoidance of an MC serogroup A epidemic. The seroprevalence of Hib antibodies was, in contrast, significantly higher in Swedish than in Sudanese children, especially for 5–9-year-old children. A possible explanation may be the different systems of day-care of children in the two countries.

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