THE IMMUNOPATHOLOGY OF UPPER GASTROINTESTINAL ACUTE GRAFT-VERSUS-HOST DISEASE LYMPHOID CELLS AND ENDOTHELIAL ADHESION MOLECULES

1993 ◽  
Vol 55 (3) ◽  
pp. 572-577 ◽  
Author(s):  
JEAN ROY ◽  
JEFFREY L. PLATT ◽  
DANIEL J. WEISDORF
Keyword(s):  
Adhesion Molecules ◽  
Graft Versus Host Disease ◽  
Lymphoid Cells ◽  
Host Disease ◽  
Graft Versus Host ◽  
Endothelial Adhesion Molecules ◽  
Upper Gastrointestinal ◽  
Acute Graft

scholarly journals Sole Upfront Therapy with Beclomethasone and Budesonide for Upper Gastrointestinal Acute Graft-versus-Host Disease

2020 ◽  
Vol 26 (7) ◽  
pp. 1303-1311
Author(s):  
Chiara Frairia ◽  
Maura Nicolosi ◽  
Jamie Shapiro ◽  
Jongphil Kim ◽  
Brian C. Betts ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Upfront Therapy ◽  
Upper Gastrointestinal ◽  
Acute Graft

Little evidence of donor-derived epithelial cells in early digestive acute graft-versus-host disease

Blood ◽  
2004 ◽  
Vol 103 (1) ◽  
pp. 360-362 ◽  
Author(s):  
Véronique Meignin ◽  
Jean Soulier ◽  
Frédéric Brau ◽  
Marc Lemann ◽  
Eliane Gluckman ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Cell Types ◽  
Lymphoid Cells ◽  
No Donor ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Duodenal Epithelium ◽  
Acute Graft

Abstract Donor origin of epithelial intestinal cells has been studied in animals and humans after transplantation and has been used as evidence of hematopoietic stem cell (HSC) plasticity. However, in the human gastrointestinal tract, no study used X- or Y-chromosome detection by fluorescence in situ hybridization (FISH) coupled with immunologic stainings to characterize cell types on the same tissue section. Here, we combined these techniques on the same section of duodenal epithelium in 6 patients with acute graft-versus-host disease. Donor-derived lymphoid cells were detected in the epithelium and the lamina propria, as expected. However, using our stringent criteria, no donor-derived cells could be proven to be epithelial.

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