Transcriptional Regulation of Th17 Cell Differentiation Mediates Ischemia-Reperfusion Injury.

2014 ◽  
Vol 98 ◽  
pp. 37
Author(s):  
J. Park ◽  
J. Lee ◽  
R. Cha ◽  
K. Yoo ◽  
S. Han ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Cell Differentiation ◽  
Reperfusion Injury ◽  
Th17 Cell ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Th17 Cell Differentiation

scholarly journals Butyric Acid Protects Against Renal Ischemia–Reperfusion Injury by Adjusting the Treg/Th17 Balance via HO-1/p-STAT3 Signaling

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhen Chen ◽  
Miaomiao Wang ◽  
Shikun Yang ◽  
Jian Shi ◽  
Tianhao Ji ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Reperfusion Injury ◽  
Butyric Acid ◽  
Th17 Cell ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Immunomodulatory Effects ◽  
Stat3 Signaling ◽  
Th17 Cell Differentiation

Immune regulation plays a vital role in ischemia–reperfusion injury (IRI). Butyric acid (BA) has immunomodulatory effects in many diseases, but its immunomodulatory effects during renal IRI are still unclear. Our research shows that BA protected against IRI and significantly improved renal IRI in vivo. In vitro studies showed that BA inhibits Th17 cell differentiation and induces Treg cell differentiation. Mechanism studies have shown that heme oxygenase 1 (HO-1)/STAT3 signaling pathway was involved in the inhibitory effect of BA on Th17 cell differentiation. HO-1 inhibitors can significantly rescue the BA-mediated inhibition of Th17 cell differentiation. We confirmed that BA promotes the differentiation of Th17 cells into Treg cells by regulating the pathway and reduces renal IRI.

scholarly journals Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

2010 ◽  
Vol 21 (6) ◽  
pp. 425-434 ◽  
Author(s):  
Kiyoshi Hirahara ◽  
Kamran Ghoreschi ◽  
Arian Laurence ◽  
Xiang-Ping Yang ◽  
Yuka Kanno ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Transcriptional Regulation ◽  
Cell Differentiation ◽  
Th17 Cell ◽  
Signal Transduction Pathways ◽  
Th17 Cell Differentiation

scholarly journals Transcriptional regulation of Th17 cell differentiation

2007 ◽  
Vol 19 (6) ◽  
pp. 409-417 ◽  
Author(s):  
Ivaylo I. Ivanov ◽  
Liang Zhou ◽  
Dan R. Littman
Keyword(s):  
Transcriptional Regulation ◽  
Cell Differentiation ◽  
Th17 Cell ◽  
Th17 Cell Differentiation

1843: Role of Cxcr2 in Renal Ischemia/Reperfusion Injury

2004 ◽  
Vol 171 (4S) ◽  
pp. 487-487
Author(s):  
Motoo Araki ◽  
Masayoshi Miura ◽  
Hiromi Kumon ◽  
John Belperio ◽  
Robert Strieter ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Renal Ischemia Reperfusion Injury

Phosphodiesterase-5-inhibition reduces ischemia/reperfusion injury after heart transplantation

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
S Loganathan ◽  
T Radovits ◽  
K Hirschberg ◽  
S Korkmaz ◽  
E Barnucz ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Phosphodiesterase 5
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