Elective lymph node dissection in stage I cutaneous malignant melanoma of the head and neck. A report from the Swedish Melanoma Study Group

1994 ◽  
Vol 4 (6) ◽  
pp. 407-411 ◽  
Author(s):  
J Hansson ◽  
U Ringborg ◽  
B Lagerl??f ◽  
L -E Afzelius ◽  
I Augustsson ◽  
...  
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Head And Neck ◽  
Lymph Node Dissection ◽  
Cutaneous Malignant Melanoma ◽  
Stage I ◽  
Study Group ◽  
Node Dissection ◽  
Elective Lymph Node Dissection

The role of elective lymph node dissection in stage I malignant melanoma

1993 ◽  
Vol 3 ◽  
pp. 36 ◽  
Author(s):  
R. Rompel ◽  
C. Garbe ◽  
P. Buttner ◽  
K. Teichelmannt ◽  
J. Petres
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Lymph Node Dissection ◽  
Stage I ◽  
Node Dissection ◽  
Elective Lymph Node Dissection

Reliability and Accuracy of Sentinel Node Biopsy in Cutaneous Malignant Melanoma

2002 ◽  
Vol 88 (3) ◽  
pp. S14-S16 ◽  
Author(s):  
P Carcoforo ◽  
G Soliani ◽  
L Bergossi ◽  
E Basaglia ◽  
AR Virgili ◽  
...  
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Sentinel Node ◽  
Lymph Node Dissection ◽  
Cutaneous Malignant Melanoma ◽  
Primary Lesion ◽  
Isosulfan Blue ◽  
Node Dissection ◽  
Positive Slns

Aims and Background The aims of this study were 1) to investigate whether sentinel lymph node (SLN) biopsy could become the method of choice for the early detection of metastatic disease in patients with malignant melanoma and 2) to identify those patients with lymph node metastases who could benefit from regional lymphadenectomy. Methods and Study Design Our study started in March 1998 and involved 110 patients with primary cutaneous malignant melanoma stage I or II (AJCC) in whom the primary lesion had been surgically removed no more than 90 days previously. On the day of lymph node dissection patients were given an intradermal injection of colloid particles of human serum albumin labeled with technetium-99m and an injection of isosulfan blue. The surgical procedure was usually performed with local anesthesia but in some cases locoregional or general anesthesia was preferred. Contralateral and ipsilateral lymphatic areas were scanned with a hand-held gamma camera (Scintiprobe MR 100) to measure the background and identify the hot point indicating the location of the sentinel node to direct the incision. Results The combined use of lymphoscintigraphy, isosulfan blue and gamma probe allowed us to identify sentinel nodes in 108 of 110 patients (98.18%) while the SLN was blue in only 90 cases (81.81%). The SLN was positive for metastases in 13 of the 108 patients (12.03%) and regional and distal lymphadenectomy was performed in all of them. The distribution of positive SLNs by primary lesion thickness was as follows: 0.76-1.5 mm: one positive SLN/44 patients (2.27%); 1.51-4 mm: six positive SLNs/51 patients (11.7%); >4 mm: six positive SLNs/15 patients (40%). Only four of 12 patients with ulcerated cutaneous melanoma had positive SLNs. The patients in our study underwent follow-up visits every four months. The median follow-up was 481 days (range, 97-1271 days). Conclusions In patients with primary cutaneous melanoma the histological status of the SLN accurately reflects the presence or absence of metastatic disease in the relevant regional lymph node basin. Complete lymph node dissection should only be performed in patients with positive SLNs. Patients with lesions >4 mm are likely to develop recurrences and to die of systemic disease, so in these patients the usefulness of SLN biopsy is questionable. In conclusion, sentinel node mapping is a rational approach for the selection of patients who might benefit from early lymph node dissection of the affected basin.

scholarly journals The role of lymph node dissection for clinical stage I malignant melanoma of intermediate thickness (1.51—3.99 mm)

Cancer ◽  
1985 ◽  
Vol 56 (2) ◽  
pp. 413-418 ◽  
Author(s):  
David E. Elder ◽  
Dupont Guerry ◽  
Marie Vanhorn ◽  
Shelley Hurwitz ◽  
Lee Zehngebot ◽  
...  
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Lymph Node Dissection ◽  
Clinical Stage ◽  
Stage I ◽  
Node Dissection
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