Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test

1997 ◽  
Vol 8 (6) ◽  
pp. 653
Author(s):  
C L??pez-Rubalcava ◽  
PA Rittenhouse ◽  
I Lucki
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Drugs ◽  
Strain Differences ◽  
Forced Swimming ◽  
Behavioral Effects ◽  
Swimming Test

scholarly journals Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test

2007 ◽  
Vol 22 (5) ◽  
pp. 351-354 ◽  
Author(s):  
Leandro Ciulla ◽  
Honório Sampaio Menezes ◽  
Bárbara Beatriz Moreira Bueno ◽  
Alexandre Schuh ◽  
Rafael José Vargas Alves ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Forced Swimming Test ◽  
Antidepressant Drugs ◽  
Forced Swimming ◽  
Behavioral Effects ◽  
Control Group ◽  
Male Wistar Rats ◽  
Swimming Test

PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significanlty reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). CONCLUSION: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.

The additive effects of quinine on antidepressant drugs in the forced swimming test in mice

1995 ◽  
Vol 121 (2) ◽  
pp. 173-179 ◽  
Author(s):  
W. Y. Guo ◽  
K. G. Todd ◽  
M. Bourin ◽  
M. Hascoet
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Drugs ◽  
Forced Swimming ◽  
Additive Effects ◽  
Swimming Test
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