THE ROLE OF SEROTONIN IN THE BEHAVIORAL EFFECTS OF ANTIDEPRESSANT DRUGS IN THE FORCED SWIMMING TEST

1996 ◽  
Vol 7 (Supplement 1) ◽  
pp. 27
Author(s):  
M J DETKE ◽  
J-P RENERIC ◽  
I I LUCK
2007 ◽  
Vol 22 (5) ◽  
pp. 351-354 ◽  
Author(s):  
Leandro Ciulla ◽  
Honório Sampaio Menezes ◽  
Bárbara Beatriz Moreira Bueno ◽  
Alexandre Schuh ◽  
Rafael José Vargas Alves ◽  
...  

PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significanlty reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). CONCLUSION: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.


1991 ◽  
Vol 105 (4) ◽  
pp. 525-529 ◽  
Author(s):  
Ella M. Nikulina ◽  
Julia A. Skrinskaya ◽  
Nina K. Popova

2011 ◽  
Vol 224 (2) ◽  
pp. 336-343 ◽  
Author(s):  
Mohammad Salehi Sadaghiani ◽  
Mehrak Javadi-Paydar ◽  
Mohammad Hadi Gharedaghi ◽  
Yashar Yousefzadeh Fard ◽  
Ahmad Reza Dehpour

2007 ◽  
Vol 575 (1-3) ◽  
pp. 87-93 ◽  
Author(s):  
Josiane Budni ◽  
Vinícius M. Gadotti ◽  
Manuella P. Kaster ◽  
Adair R.S. Santos ◽  
Ana Lúcia S. Rodrigues

2011 ◽  
Vol 59 (5) ◽  
pp. 628-636 ◽  
Author(s):  
Patricia Rojas ◽  
Norma Serrano-García ◽  
Omar N. Medina-Campos ◽  
José Pedraza-Chaverri ◽  
Sven O. Ögren ◽  
...  

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