Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
2007 ◽
Vol 22
(5)
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pp. 351-354
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Keyword(s):
PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significanlty reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). CONCLUSION: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.
2008 ◽
Vol 23
(5)
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pp. 447-450
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Keyword(s):
Strain Differences in the Behavioral Effects of Antidepressant Drugs in the Rat Forced Swimming Test
2000 ◽
Vol 22
(2)
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pp. 191-199
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Keyword(s):
Keyword(s):
1997 ◽
Vol 8
(6)
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pp. 523-532
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Keyword(s):
2005 ◽
Vol 29
(4-5)
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pp. 547-569
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Keyword(s):
2013 ◽
Vol 110
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pp. 89-97
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Keyword(s):
2021 ◽
Vol 10
(4)
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pp. 391