Postinfantile giant cell hepatitis with autoimmune features following a human herpesvirus 6-induced adverse drug reaction

2005 ◽  
Vol 17 (10) ◽  
pp. 1131-1134 ◽  
Author(s):  
Thomas Kuntzen ◽  
Nicolaus Friedrichs ◽  
Hans Peter Fischer ◽  
Anna Maria Eis-H??binger ◽  
Tilman Sauerbruch ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Giant Cell ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Giant Cell Hepatitis

Cytomegalovirus and Human Herpesvirus 6, but Not Human Papillomavirus, Are Present in Neonatal Giant Cell Hepatitis and Extrahepatic Biliary Atresia

2000 ◽  
Vol 3 (4) ◽  
pp. 367-373 ◽  
Author(s):  
Rana Domiati-Saad ◽  
D. Brian Dawson ◽  
Linda R. Margraf ◽  
Milton J. Finegold ◽  
Arthur G. Weinberg ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Biliary Atresia ◽  
Giant Cell ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
Hepatic Tissue ◽  
Pcr Analysis ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Giant Cell Hepatitis

The purpose of our study was to confirm reports of an association of human papillomavirus (HPV) with neonatal giant cell hepatitis (GCH) and biliary atresia (BA), and to expand these studies to include cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV6), and parvovirus B19 (PVB19). Frozen hepatic tissue was available for polymerase chain reaction (PCR) analysis in 19 cases of GCH or BA and 8 controls. Nested PCR to detect HPV types 6, 16, 18, and 33 was followed by 32P hybridization with generic probes. PCR followed by hybridization with a digoxigenin-labeled probe was used for all other viruses. HPV, EBV, and PVB19 were not detected in cases or controls. Two cases of GCH and 1 case of BA were PCR positive for CMV; controls were negative. HHV6 was detected in 6 cases: 2 GCH, 2 BA, and 2 controls. We conclude that HPV is not associated with GCH or BA. Detection of CMV in BA and GCH confirms other reports of this association. HHV6 requires further study to determine the significance of a positive PCR test in the livers of infants.

scholarly journals Drug Reaction with Eosinophilia and Systemic Symptoms: DRESS following Initiation of Oxcarbazepine with Elevated Human Herpesvirus-6 Titer

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Seth L. Cornell ◽  
Daniel DiBlasi ◽  
Navin S. Arora
Keyword(s):  
Drug Reaction ◽  
Rare Case ◽  
Human Herpesvirus ◽  
Complete Recovery ◽  
Human Herpesvirus 6 ◽  
Delayed Onset ◽  
Aggressive Management ◽  
Herpesvirus 6 ◽  
Systemic Symptoms ◽  
Severe Cutaneous Reaction

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal severe cutaneous reaction, which has a delayed onset after the initiation of an inciting medication. After recognition and withdrawal of the causative agent, along with aggressive management, a majority of patients will have complete recovery over several months. We present a rare case of DRESS secondary to oxcarbazepine with an elevated human herpesvirus-6 titer.

scholarly journals Association of Immunologically Confirmed Delayed Drug Reaction and Human Herpesvirus 6 Viremia in a Pediatric Case of Drug-Induced Hypersensitivity Syndrome

Dermatology ◽  
2011 ◽  
Vol 222 (2) ◽  
pp. 140-141 ◽  
Author(s):  
Thomas Hubiche ◽  
Brigitte Milpied ◽  
Christine Cazeau ◽  
Alain Taïeb ◽  
Christine Léauté-Labrèze
Keyword(s):  
Drug Reaction ◽  
Human Herpesvirus ◽  
Hypersensitivity Syndrome ◽  
Human Herpesvirus 6 ◽  
Pediatric Case ◽  
Drug Induced ◽  
Herpesvirus 6
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