Cytomegalovirus and Human Herpesvirus 6, but Not Human Papillomavirus, Are Present in Neonatal Giant Cell Hepatitis and Extrahepatic Biliary Atresia

2000 ◽  
Vol 3 (4) ◽  
pp. 367-373 ◽  
Author(s):  
Rana Domiati-Saad ◽  
D. Brian Dawson ◽  
Linda R. Margraf ◽  
Milton J. Finegold ◽  
Arthur G. Weinberg ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Biliary Atresia ◽  
Giant Cell ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
Hepatic Tissue ◽  
Pcr Analysis ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Giant Cell Hepatitis

The purpose of our study was to confirm reports of an association of human papillomavirus (HPV) with neonatal giant cell hepatitis (GCH) and biliary atresia (BA), and to expand these studies to include cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV6), and parvovirus B19 (PVB19). Frozen hepatic tissue was available for polymerase chain reaction (PCR) analysis in 19 cases of GCH or BA and 8 controls. Nested PCR to detect HPV types 6, 16, 18, and 33 was followed by 32P hybridization with generic probes. PCR followed by hybridization with a digoxigenin-labeled probe was used for all other viruses. HPV, EBV, and PVB19 were not detected in cases or controls. Two cases of GCH and 1 case of BA were PCR positive for CMV; controls were negative. HHV6 was detected in 6 cases: 2 GCH, 2 BA, and 2 controls. We conclude that HPV is not associated with GCH or BA. Detection of CMV in BA and GCH confirms other reports of this association. HHV6 requires further study to determine the significance of a positive PCR test in the livers of infants.

Postinfantile giant cell hepatitis with autoimmune features following a human herpesvirus 6-induced adverse drug reaction

2005 ◽  
Vol 17 (10) ◽  
pp. 1131-1134 ◽  
Author(s):  
Thomas Kuntzen ◽  
Nicolaus Friedrichs ◽  
Hans Peter Fischer ◽  
Anna Maria Eis-H??binger ◽  
Tilman Sauerbruch ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Giant Cell ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Giant Cell Hepatitis

scholarly journals Human herpesvirus 6 infects cervical epithelial cells and transactivates human papillomavirus gene expression.

1994 ◽  
Vol 68 (2) ◽  
pp. 1173-1178 ◽  
Author(s):  
M Chen ◽  
N Popescu ◽  
C Woodworth ◽  
Z Berneman ◽  
M Corbellino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Cervical Epithelial Cells ◽  
Herpesvirus 6

scholarly journals Association of Active Human Herpesvirus-6, -7 and Parvovirus B19 Infection with Clinical Outcomes in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Svetlana Chapenko ◽  
Angelika Krumina ◽  
Inara Logina ◽  
Santa Rasa ◽  
Maksims Chistjakovs ◽  
...  
Keyword(s):  
Viral Infection ◽  
Proinflammatory Cytokines ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
High Rate ◽  
Simultaneous Increase ◽  
Concurrent Infection ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Healthy Persons

Frequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection and its association with clinical course of ME/CFS was evaluated. 108 ME/CFS patients and 90 practically healthy persons were enrolled in the study. Viral genomic sequences were detected by PCR, virus-specific antibodies and cytokine levels—by ELISA, HHV-6 variants—by restriction analysis. Active viral infection including concurrent infection was found in 64.8% (70/108) of patients and in 13.3% (12/90) of practically healthy persons. Increase in peripheral blood leukocyte DNA HHV-6 load as well as in proinflammatory cytokines' levels was detected in patients during active viral infection. Definite relationship was observed between active betaherpesvirus infection and subfebrility, lymphadenopathy and malaise after exertion, and between active B19 infection and multijoint pain. Neuropsychological disturbances were detected in all patients. The manifestation of symptoms was of more frequent occurrence in patients with concurrent infection. The high rate of active HHV-6, HHV-7 and B19 infection/coinfection with the simultaneous increase in plasma proinflammatory cytokines' level as well as the association between active viral infection and distinctive types of clinical symptoms shows necessity of simultaneous study of these viral infections for identification of possible subsets of ME/CFS.

A meta-analysis on association between viral infections and Kawasaki disease in children

2021 ◽  
Vol 16 (1) ◽  
pp. 27-41
Author(s):  
Mohammad Farahmand ◽  
Abbas Ahmadi-Vasmehjani ◽  
Abdoulreza Esteghamati ◽  
Shirin Sayyahfar ◽  
Sara Minaeian ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Viral Infections ◽  
Parvovirus B19 ◽  
Meta Analysis ◽  
Human Herpesvirus ◽  
Human Parvovirus B19 ◽  
Human Herpesvirus 6 ◽  
Viral Pathogens ◽  
Inverse Variance ◽  
Herpesvirus 6

Aim: To investigate the association between different viral infections and the development of Kawasaki disease (KD) in children. Materials & methods: Electronic databases were searched for relevant studies published from inception to May 2020. The pooled odds ratios (ORs) of the association of different viral pathogens with KD were estimated using a random-effects model weighted by the inverse variance method. Results: The strongest associations were found between KD and human parvovirus B19 viremia (OR = 41.05; 95% CI: 5.13–328.28; I-square = 0%), EBV IgM seropositivity (OR = 7.18; 95% CI: 3.65–14.12, I-square = 0%) and human herpesvirus-6 IgG seropositivity (OR = 5.83; 95% CI: 1.06–32.01). Conclusion: Human parvovirus B19, EBV and human herpesvirus-6 are highly suspected to be key contributors to the development of KD.

scholarly journals Detection of parvovirus B19 and human herpesvirus 6 in pediatric dilated cardiomyopathy: Impact after heart transplantation

2020 ◽  
Vol 13 (4) ◽  
pp. 301
Author(s):  
BibhutiB Das ◽  
BhupeshK Prusty ◽  
Jianli Niu ◽  
Meei-Li Huang ◽  
Haiying Zhu ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Dilated Cardiomyopathy ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

scholarly journals Human Herpesvirus 6 Open Reading Frame U83 Encodes a Functional Chemokine

1999 ◽  
Vol 73 (7) ◽  
pp. 5926-5933 ◽  
Author(s):  
Ping Zou ◽  
Yuji Isegawa ◽  
Kazusi Nakano ◽  
M. Haque ◽  
Yasuhiko Horiguchi ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Mononuclear Cells ◽  
Biological Function ◽  
Human Herpesvirus ◽  
Open Reading Frame ◽  
Pcr Analysis ◽  
Human Herpesvirus 6 ◽  
Antibody Testing ◽  
Reading Frame ◽  
Herpesvirus 6

ABSTRACT Some viruses including herpesviruses have undergone evolution to benefit viral infection and propagation by pirating and modifying host genes such as chemokine genes. Human herpesvirus 6 (HHV-6), acutely or persistently infects mononuclear cells in vitro. DNA sequence analysis of HHV-6 has revealed that the putative protein encoded by an open reading frame (ORF) of the U83 gene in HHV-6 variant B resembled a human chemokine. We have cloned the U83 gene and analyzed the biological function of this gene. The U83 gene contained an ORF encoding a 113-amino-acid peptide, starting at the first methionine and containing a possible signal peptide and the typical cysteine residues characteristic of the chemokines. Reverse transcription-PCR analysis of mRNA and immunofluorescent-antibody testing of infected cells both indicated that the encoded protein was a late protein. The ORF U83 gene fused to the Fc gene was expressed as a fusion protein in COS-7 cells by transfection, and the fusion protein was purified from the supernatant of transfected cells to test its biological function. The purified protein was capable of inducing transient calcium mobilization in THP-1 cells and of chemotactically activating THP-1 cells. These findings suggested that the U83 protein might play an important role in HHV-6 propagation in vivo by activating and trafficking mononuclear cells to sites of viral replication, thus aiding the development of superbly efficient virus production mechanisms.

scholarly journals Primary human herpesvirus-6 and -7 infections, often coinciding, misdiagnosed as measles in children from a tropical region of Brazil

2003 ◽  
Vol 131 (2) ◽  
pp. 873-879 ◽  
Author(s):  
S. A. OLIVEIRA ◽  
D. J. TURNER ◽  
W. KNOWLES ◽  
J. P. NASCIMENTO ◽  
D. W. G. BROWN ◽  
...  
Keyword(s):  
Indirect Immunofluorescence ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
Tropical Region ◽  
Human Herpesvirus 6 ◽  
Antibody Avidity ◽  
Tropical Conditions ◽  
Herpesvirus 6 ◽  
Immunofluorescence Antibody ◽  
Brazilian Children

We investigated primary human herpesvirus-6 and -7 (HHV-6, HHV-7) infections as a cause of rashes incorrectly diagnosed as measles in Brazilian children. Sera from 124 patients, aged 4 months to 17 years, from the states of Rio de Janeiro and Espírito Santo, in whom measles, rubella and parvovirus B19 infections had been excluded, were studied using indirect immunofluorescence antibody avidity tests; 38 (31%) had evidence of primary HHV-6 and/or HHV-7 infections. Twenty four children had primary HHV-6 infection, either recent or coincident with the rash, and similarly 31 had primary HHV-7 infection. Remarkably, almost half (17) of primary infections were dual HHV-6 and HHV-7 infections with the majority, 12 (71%), in children less than 1 year old. HHV-7 infection occurred earlier than previously reported, perhaps due to socioeconomic and tropical conditions in this region of Brazil, and thus coincided with the HHV-6 infections. This study also highlights the difficulties of diagnosing a rash illness on clinical grounds alone.

scholarly journals Fatal Myocarditis Associated with Acute Parvovirus B19 and Human Herpesvirus 6 Coinfection

2001 ◽  
Vol 39 (12) ◽  
pp. 4585-4587 ◽  
Author(s):  
J. Rohayem ◽  
J. Dinger ◽  
R. Fischer ◽  
K. Klingel ◽  
R. Kandolf ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6
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