Relationship between apoE4 allele and excitatory amino acid levels after traumatic brain injury

2003 ◽  
Vol 31 (9) ◽  
pp. 2371-2379 ◽  
Author(s):  
Mary E. Kerr ◽  
M. Ilyas Kamboh ◽  
Kim Yookyung ◽  
Marilyn F. Kraus ◽  
Ava M. Puccio ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Amino Acid ◽  
Brain Injury ◽  
Excitatory Amino Acid ◽  
Apoe4 Allele ◽  
Amino Acid Levels

The expression of excitatory amino acid transporter 2 in traumatic brain injury

2002 ◽  
Vol 130 (2-3) ◽  
pp. 83-89 ◽  
Author(s):  
Kazuya Ikematsu ◽  
Ryouichi Tsuda ◽  
Toshikazu Kondo ◽  
Ichiro Nakasono
Keyword(s):  
Traumatic Brain Injury ◽  
Amino Acid ◽  
Brain Injury ◽  
Excitatory Amino Acid ◽  
Amino Acid Transporter ◽  
Excitatory Amino Acid Transporter ◽  
Acid Transporter

Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans

1993 ◽  
Vol 79 (3) ◽  
pp. 369-372 ◽  
Author(s):  
Andrew J. Baker ◽  
Richard J. Moulton ◽  
Vernon H. MacMillan ◽  
Peter M. Shedden
Keyword(s):  
Amino Acids ◽  
Traumatic Brain Injury ◽  
Cerebrospinal Fluid ◽  
Amino Acid ◽  
Brain Injury ◽  
Excitatory Amino Acids ◽  
Excitatory Amino Acid ◽  
Neuronal Damage ◽  
Control Group ◽  
Injured Patients

✓ Evidence from models of traumatic brain injury implicates excitotoxicity as an integral process in the ultimate neuronal damage that follows. Concentrations of the excitatory amino acid glutamate were serially measured in the cerebrospinal fluid (CSF) of patients with traumatic brain injuries and in control patients for comparison. The purpose of the study was to determine whether glutamate concentrations were significantly elevated following traumatic brain injury and, if so, whether they were elevated in a time frame that would allow the use of antagonist therapy. Cerebrospinal fluid was sampled fresh from ventricular drains every 12 hours and analyzed using high-performance liquid chromatography for the excitatory amino acids. The peak concentrations of glutamate in the CSF of the 12 brain-injured patients ranged from 14 to 474 µM and were significantly higher than those in the three control patients, 4.9 to 17 µM (Mann-Whitney U-test, p < 0.02). Glutamate concentrations in five of the eight patients who were still being sampled on Day 3 were beyond the control group range. The implication of this study is that severely head-injured patients are exposed to high concentrations of a neurotoxic amino acid for days following injury and thus may benefit from antagonist intervention.

Excitatory amino acid receptor subtype binding following traumatic brain injury

1990 ◽  
Vol 526 (1) ◽  
pp. 103-107 ◽  
Author(s):  
L.P. Miller ◽  
B.G. Lyeth ◽  
L.W. Jenkins ◽  
L. Oleniak ◽  
D. Panchision ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Amino Acid ◽  
Brain Injury ◽  
Excitatory Amino Acid ◽  
Receptor Subtype ◽  
Excitatory Amino Acid Receptor ◽  
Acid Receptor

Role of Excitatory Amino Acid-Mediated Ionic Fluxes in Traumatic Brain Injury

1995 ◽  
Vol 5 (4) ◽  
pp. 427-435 ◽  
Author(s):  
Yoichi Katayama ◽  
Takeshi Maeda ◽  
Morimichi Koshinaga ◽  
Tatsuro Kawamata ◽  
Takashi Tsubokawa
Keyword(s):  
Traumatic Brain Injury ◽  
Amino Acid ◽  
Brain Injury ◽  
Excitatory Amino Acid ◽  
Ionic Fluxes
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