Amiloride combined with small-volume resuscitation with hypertonic saline is superior in ameliorating trauma-hemorrhagic shock-induced lung injury in rats to the administration of either agent alone

2005 ◽  
Vol 33 (11) ◽  
pp. 2592-2598 ◽  
Author(s):  
Naohiko Fujiyoshi ◽  
Edwin A. Deitch ◽  
Eleonora Feketeova ◽  
Qi Lu ◽  
Tamara L. Berezina ◽  
...  
Keyword(s):  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Hypertonic Saline ◽  
Small Volume ◽  
Volume Resuscitation

SMALL VOLUME RESUSCITATION FROM HEMORRHAGIC SHOCK IN DOGS WITH HYPERTONIC SALINE-HYDROXYETHYL STARCH SOLUTIONS

1988 ◽  
Vol 69 (3A) ◽  
pp. A847-A847 ◽  
Author(s):  
J. M. Whitley ◽  
D. S. Prough ◽  
D. D. Deal ◽  
A. K. Lamb ◽  
D. S. DeWitt
Keyword(s):  
Hemorrhagic Shock ◽  
Hypertonic Saline ◽  
Hydroxyethyl Starch ◽  
Small Volume ◽  
Volume Resuscitation

Nebulized hypertonic saline attenuates lung injury following hemorrhagic shock

2010 ◽  
Vol 211 (3) ◽  
pp. S125
Author(s):  
Max Wohlauer ◽  
Ernest E. Moore ◽  
Miguel Fragoso ◽  
Franklin Wright ◽  
John Eun ◽  
...  
Keyword(s):  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Hypertonic Saline

Hypertonic hydroxyethyl starch restores hepatic microvascular perfusion in hemorrhagic shock

1994 ◽  
Vol 266 (5) ◽  
pp. H1927-H1934 ◽  
Author(s):  
B. Vollmar ◽  
G. Lang ◽  
M. D. Menger ◽  
K. Messmer
Keyword(s):  
Hemorrhagic Shock ◽  
Hydroxyethyl Starch ◽  
Small Volume ◽  
Microvascular Perfusion ◽  
Volume Resuscitation ◽  
Shock Model ◽  
Intravital Fluorescence Microscopy ◽  
Ringer Lactate ◽  
Endothelial Lining ◽  
Perfusion Failure

The influence of small-volume resuscitation (hypertonic saline-10% hydroxyethyl starch, HS/HES) on liver microcirculation (intravital fluorescence microscopy) was studied in a nonheparinized hemorrhagic shock model [mean arterial pressure (MAP) 40 mmHg for 1 h] in rats. Resuscitation was performed with Ringer lactate (RL, 4-fold shed volume/20 min; n = 7), 10% hydroxyethyl starch 200/0.6 (HES, shed volume/5 min; n = 6), or 7.2% NaCl-10% hydroxyethyl starch 200/0.6 (HS/HES, 10% shed volume/2 min; n = 7). One hour after resuscitation, MAP increased in all groups, but it did not return to preshock values (P < 0.05). HES (16 +/- 2% nonperfused sinusoids) and HS/HES (14 +/- 2% nonperfused sinusoids), but not RL (24 +/- 2% nonperfused sinusoids), reduced (P < 0.05) shock-induced sinusoidal perfusion failure (28 +/- 3%) with restoration of leukocyte velocity in sinusoids (S) and postsinusoidal venules (V). Shock-induced stasis/adherence of leukocytes was further increased (P < 0.05) after resuscitation with RL (S, 38 +/- 6%; V, 55 +/- 20%) and HES (S, 31 +/- 8%; V, 23 +/- 14%). In contrast, resuscitation with HS/HES prevented increased leukocyte stasis in sinusoids (-4 +/- 4%) as well as adherence to endothelial lining of postsinusoidal venules (-5 +/- 10%). We conclude that replacement of only 10% of actual blood loss by means of small-volume resuscitation (HS/HES) can restore hepatic microvascular perfusion and prevent reperfusion-induced leukocyte stasis/adherence.

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