Challenges in breast cancer clinical trial design in the postgenomic era

2004 ◽  
Vol 16 (6) ◽  
pp. 536-541 ◽  
Author(s):  
Sherene Loi ◽  
Marc Buyse ◽  
Christos Sotiriou ◽  
Fatima Cardoso
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Cancer Clinical Trial

Shifting paradigms in cancer clinical trial design

2014 ◽  
Vol 11 (11) ◽  
pp. 625-626 ◽  
Author(s):  
Daniel J. Sargent ◽  
Edward L. Korn
Keyword(s):  
Clinical Trial ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Cancer Clinical Trial

Genomic Analysis of Breast Cancer Heralds a Changing Treatment Paradigm

2014 ◽  
Vol 12 (5S) ◽  
pp. 750-752
Author(s):  
Matthew Ellis
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Molecular Biology ◽  
Trial Design ◽  
Molecular Subtypes ◽  
Clinical Trial Design ◽  
Genomic Analysis ◽  
Driver Mutations ◽  
Annual Conference ◽  
Treatment Paradigm

Deep genomic analysis in breast cancer and the identification of driver mutations will result in treatments based on molecular subtypes and pathways. Mutations not yet familiar to most oncologists will become part of the clinical oncology vernacular. Such discoveries will advance the concept of “biology first, not drug first,” because molecular biology will drive drug development and clinical trial design involving small, molecularly defined subsets of patients, according to a presentation at the NCCN 19th Annual Conference.

An Empirical Investigation of Bayesian Clinical Trial Design in Metastatic Breast Cancer

2019 ◽  
Vol 54 (4) ◽  
pp. 861-869
Author(s):  
Erik Bloomquist ◽  
Susan Jin ◽  
Jiaxi Zhou ◽  
Shenghui Tang ◽  
Rajeshwari Sridhara
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Metastatic Breast Cancer ◽  
Trial Design ◽  
Empirical Investigation ◽  
Metastatic Breast ◽  
Clinical Trial Design
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