scholarly journals Searching for Therapies to Treat Rare Ocular Melanoma

2022 ◽  
Vol 44 (1) ◽  
pp. 1,13-14
Author(s):  
Valerie Neff Newitt
Keyword(s):  
Ocular Melanoma

Collaborative Ocular Melanoma Study Group

1999 ◽  
Vol 8 (1) ◽  
pp. 11-a-12
Author(s):  
S. L. Fine
Keyword(s):  
Ocular Melanoma ◽  
Study Group

scholarly journals Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jie Yu ◽  
Peiwei Chai ◽  
Minyue Xie ◽  
Shengfang Ge ◽  
Jing Ruan ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
Regulation Of Gene Expression ◽  
Metabolic Stress ◽  
Ocular Melanoma ◽  
Rna Modifications ◽  
M1 Macrophage ◽  
Melanoma Therapy

Abstract Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, the role of histone lactylation in tumorigenesis remains unclear. Results Here, we show histone lactylation is elevated in tumors and is associated with poor prognosis of ocular melanoma. Target correction of aberrant histone lactylation triggers therapeutic efficacy both in vitro and in vivo. Mechanistically, histone lactylation contributes to tumorigenesis by facilitating YTHDF2 expression. Moreover, YTHDF2 recognizes the m6A modified PER1 and TP53 mRNAs and promotes their degradation, which accelerates tumorigenesis of ocular melanoma. Conclusion We reveal the oncogenic role of histone lactylation, thereby providing novel therapeutic targets for ocular melanoma therapy. We also bridge histone modifications with RNA modifications, which provides novel understanding of epigenetic regulation in tumorigenesis.

Risk of ocular melanoma in relation to cutaneous and IRIS naevi

1995 ◽  
Vol 60 (5) ◽  
pp. 622-626 ◽  
Author(s):  
Veronique Bataille ◽  
Peter Sasieni ◽  
Jack Cuzick ◽  
John L. Hungerford ◽  
Anthony Swerdlow ◽  
...  
Keyword(s):  
Ocular Melanoma

scholarly journals Response of an ocular melanoma to subconjunctival injection of 5-Thio-D-glucose or cis-platin

1987 ◽  
Vol 55 (5) ◽  
pp. 499-502 ◽  
Author(s):  
KA Skov ◽  
C Kumi ◽  
J Rootman ◽  
N Bussanich ◽  
MO Fellenz
Keyword(s):  
Ocular Melanoma ◽  
Subconjunctival Injection

Overexpression of hepatocyte growth factor and an oncogenic CDK4 variant in mice alters corneal stroma morphology but does not lead to spontaneous ocular melanoma

2016 ◽  
Vol 26 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Marta M. Kilian ◽  
Martina C. Herwig ◽  
Frank G. Holz ◽  
Thomas Tüting ◽  
Karin U. Loeffler
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Corneal Stroma ◽  
Ocular Melanoma ◽  
Hepatocyte Growth

Scintigraphic visualization of ocular melanoma with Tc-99m glutathione

1997 ◽  
Vol 11 (2) ◽  
pp. 143-146 ◽  
Author(s):  
Ahmet Tutuş ◽  
Kuddusi Erkiliç ◽  
Meral T. Ercan ◽  
Olgun Kontaş ◽  
Mehmet Aydin ◽  
...  
Keyword(s):  
Ocular Melanoma
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