scholarly journals Pulmonary Mycobacterium avium Complex Infection in HIV-Infected Patient After Immune Reconstitution With Highly Active Antiretroviral Therapy

2004 ◽  
Vol 12 (3) ◽  
pp. 171-173 ◽  
Author(s):  
Ighovwerha Ofotokun ◽  
Ketan P. Buch ◽  
Eun Young Lee ◽  
Ardis Hoven
2007 ◽  
Vol 49 (4) ◽  
pp. 267-270 ◽  
Author(s):  
Marcelo Corti ◽  
María F. Villafañe ◽  
Marta Ambroggi ◽  
Mirna Sawicki ◽  
Elisa Gancedo

Immune reconstitution inflammatory syndrome (IRIS) is an atypical and unexpected reaction related to highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV) infected patients. IRIS includes an atypical response to an opportunistic pathogen (generally Mycobacterium tuberculosis, Mycobacterium avium complex, cytomegalovirus and herpes varicella-zoster), in patients responding to HAART with a reduction of plasma viral load and evidence of immune restoration based on increase of CD4+ T-cell count. We reported a case of a patient with AIDS which, after a first failure of HAART, developed a subcutaneous abscess and supraclavicular lymphadenitis as an expression of IRIS due to Mycobacterium avium complex after starting a second scheme of HAART.


2021 ◽  
Vol 80 (2) ◽  
pp. 173-178
Author(s):  
Roxana Carmen Cernat ◽  
Irina Magdalena Dumitru ◽  
Carmen Ilie Serban

The incidence of Mycobacterium avium Complex (MAC) Disease in HIV-infected individuals has significantly decreased in recent years due to the introduction of Highly Active Antiretroviral Therapy (HAART) and the initiation of Clarithromycin prophylaxis. We present the case of a patient with advanced AIDS, with generalized lymphadenopathy and digestive symptoms, diagnosed with disseminated MAC, a diagnosis which was based on the results obtained from axillary lymph node and intestinal biopsies. Considering the time of the MAC diagnosis in relation to the recent introduction of antiretroviral (ARV) therapy, we considered immune reconstitution inflammatory syndrome (IRIS) with good evolution under azithromycin, ethambutol and moxifloxacin treatment.


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